Clinical characteristics and prognosis in a large paediatric cohort with status epilepticus
•A nationwide multicenter Chinese study of children with status epilepticus (SE).•Enrolled 4255 inpatient children with SE from 44 hospitals between 2013 and 2015.•Acute symptomatic aetiology was the most common cause of SRSE.•In-hospital mortality rates: 15.2 % (SRSE) and 1.4 % (non-SRSE).•SRSE was...
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| Veröffentlicht in: | Seizure (London, England) England), 2020-08, Vol.80, p.5-11 |
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| creator | Wang, Tianqi Wang, Ji Dou, Yalan Yan, Weili Ding, Ding Lu, Guoping Ma, Jian Zhou, Yuanfeng Li, Taoli Zhou, Shuizhen Wang, Yi |
| description | •A nationwide multicenter Chinese study of children with status epilepticus (SE).•Enrolled 4255 inpatient children with SE from 44 hospitals between 2013 and 2015.•Acute symptomatic aetiology was the most common cause of SRSE.•In-hospital mortality rates: 15.2 % (SRSE) and 1.4 % (non-SRSE).•SRSE was factor for in-hospital mortality and short-term neurological dysfunction.
To describe the aetiology, clinical features, and short-term outcomes of children with status epilepticus (SE), in particular super-refractory SE (SRSE), by a nationwide multicentre study in China.
In this retrospective study, inpatient children with SE were identified from neurology departments and paediatric intensive care units from 44 hospitals in 27 provinces of China between 2013 and 2015. Clinical data were exported from the Hospital Information System.
Clinical records from children with SE (n = 4255) aged 1 month to 18 years were enrolled; 13.1 % were diagnosed with SRSE. The most common known SE aetiology was acute symptomatic aetiology (42.8 %) and 50.2 % of SE was caused by epilepsy of unknown aetiology. Acute central nervous system (CNS) infections (38.8 %) were associated with SRSE (P < 0.001). The overall SE in-hospital mortality rate was 3.0 %, which was significantly higher in the children with SRSE than in those with non-SRSE (15.2 % versus 1.4 %, respectively; P < 0.001). Fourteen percent of the children with SE had various levels of neurological dysfunction at discharge. SRSE was a risk factor for in-hospital mortality (hazard ratio = 4.14; 95 % confidence interval [CI]: 2.34−7.32; P < 0.001) and neurological dysfunction at discharge (odds ratio = 2.85; 95 % CI: 1.90−4.27; P < 0.001).
Acute symptomatic aetiology was the most common known cause of paediatric SE. Aetiology was associated with progression to SRSE and short-term neurological dysfunction at discharge. Furthermore, SRSE was considered a risk factor for in-hospital mortality and short-term neurological dysfunction. |
| doi_str_mv | 10.1016/j.seizure.2020.04.001 |
| format | Article |
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To describe the aetiology, clinical features, and short-term outcomes of children with status epilepticus (SE), in particular super-refractory SE (SRSE), by a nationwide multicentre study in China.
In this retrospective study, inpatient children with SE were identified from neurology departments and paediatric intensive care units from 44 hospitals in 27 provinces of China between 2013 and 2015. Clinical data were exported from the Hospital Information System.
Clinical records from children with SE (n = 4255) aged 1 month to 18 years were enrolled; 13.1 % were diagnosed with SRSE. The most common known SE aetiology was acute symptomatic aetiology (42.8 %) and 50.2 % of SE was caused by epilepsy of unknown aetiology. Acute central nervous system (CNS) infections (38.8 %) were associated with SRSE (P < 0.001). The overall SE in-hospital mortality rate was 3.0 %, which was significantly higher in the children with SRSE than in those with non-SRSE (15.2 % versus 1.4 %, respectively; P < 0.001). Fourteen percent of the children with SE had various levels of neurological dysfunction at discharge. SRSE was a risk factor for in-hospital mortality (hazard ratio = 4.14; 95 % confidence interval [CI]: 2.34−7.32; P < 0.001) and neurological dysfunction at discharge (odds ratio = 2.85; 95 % CI: 1.90−4.27; P < 0.001).
Acute symptomatic aetiology was the most common known cause of paediatric SE. Aetiology was associated with progression to SRSE and short-term neurological dysfunction at discharge. Furthermore, SRSE was considered a risk factor for in-hospital mortality and short-term neurological dysfunction.</description><identifier>ISSN: 1059-1311</identifier><identifier>EISSN: 1532-2688</identifier><identifier>DOI: 10.1016/j.seizure.2020.04.001</identifier><language>eng</language><publisher>Elsevier Ltd</publisher><subject>Children ; Prognosis ; Status epilepticus ; Super-refractory status epilepticus</subject><ispartof>Seizure (London, England), 2020-08, Vol.80, p.5-11</ispartof><rights>2020</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c389t-6a3ef1956165afc0f647c69415aa93cea355f69a1411868e0649a444b78f7e3e3</citedby><cites>FETCH-LOGICAL-c389t-6a3ef1956165afc0f647c69415aa93cea355f69a1411868e0649a444b78f7e3e3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.seizure.2020.04.001$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3550,27924,27925,45995</link.rule.ids></links><search><creatorcontrib>Wang, Tianqi</creatorcontrib><creatorcontrib>Wang, Ji</creatorcontrib><creatorcontrib>Dou, Yalan</creatorcontrib><creatorcontrib>Yan, Weili</creatorcontrib><creatorcontrib>Ding, Ding</creatorcontrib><creatorcontrib>Lu, Guoping</creatorcontrib><creatorcontrib>Ma, Jian</creatorcontrib><creatorcontrib>Zhou, Yuanfeng</creatorcontrib><creatorcontrib>Li, Taoli</creatorcontrib><creatorcontrib>Zhou, Shuizhen</creatorcontrib><creatorcontrib>Wang, Yi</creatorcontrib><creatorcontrib>the Chinese Paediatric Status Epilepticus Task Force</creatorcontrib><title>Clinical characteristics and prognosis in a large paediatric cohort with status epilepticus</title><title>Seizure (London, England)</title><description>•A nationwide multicenter Chinese study of children with status epilepticus (SE).•Enrolled 4255 inpatient children with SE from 44 hospitals between 2013 and 2015.•Acute symptomatic aetiology was the most common cause of SRSE.•In-hospital mortality rates: 15.2 % (SRSE) and 1.4 % (non-SRSE).•SRSE was factor for in-hospital mortality and short-term neurological dysfunction.
To describe the aetiology, clinical features, and short-term outcomes of children with status epilepticus (SE), in particular super-refractory SE (SRSE), by a nationwide multicentre study in China.
In this retrospective study, inpatient children with SE were identified from neurology departments and paediatric intensive care units from 44 hospitals in 27 provinces of China between 2013 and 2015. Clinical data were exported from the Hospital Information System.
Clinical records from children with SE (n = 4255) aged 1 month to 18 years were enrolled; 13.1 % were diagnosed with SRSE. The most common known SE aetiology was acute symptomatic aetiology (42.8 %) and 50.2 % of SE was caused by epilepsy of unknown aetiology. Acute central nervous system (CNS) infections (38.8 %) were associated with SRSE (P < 0.001). The overall SE in-hospital mortality rate was 3.0 %, which was significantly higher in the children with SRSE than in those with non-SRSE (15.2 % versus 1.4 %, respectively; P < 0.001). Fourteen percent of the children with SE had various levels of neurological dysfunction at discharge. SRSE was a risk factor for in-hospital mortality (hazard ratio = 4.14; 95 % confidence interval [CI]: 2.34−7.32; P < 0.001) and neurological dysfunction at discharge (odds ratio = 2.85; 95 % CI: 1.90−4.27; P < 0.001).
Acute symptomatic aetiology was the most common known cause of paediatric SE. Aetiology was associated with progression to SRSE and short-term neurological dysfunction at discharge. Furthermore, SRSE was considered a risk factor for in-hospital mortality and short-term neurological dysfunction.</description><subject>Children</subject><subject>Prognosis</subject><subject>Status epilepticus</subject><subject>Super-refractory status epilepticus</subject><issn>1059-1311</issn><issn>1532-2688</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><recordid>eNqFkM1OwzAQhC0EElB4BCQfuSTYseM6J4Qq_qRKXODEwVrcTesqTYLXAcHTY1TunHYOM6PZj7ELKUoppLnaloThe4pYVqISpdClEPKAnchaVUVlrD3MWtRNIZWUx-yUaCuEaLRUJ-x10YU-eOi430AEnzAGSsETh37Fxzis-4EC8dBz4B3ENfIRcBUgxeC5HzZDTPwzpA2nBGkijmPocMwNE52xoxY6wvO_O2Mvd7fPi4di-XT_uLhZFl7ZJhUGFLayqY00NbRetEbPvcnzaoBGeQRV161pQGoprbEojG5Aa_02t-0cFaoZu9z35rnvE1Jyu0Aeuw56HCZylRbWal1VNlvrvdXHgShi68YYdhC_nBTuF6bbuj-Y7hemE9plmDl3vc9h_uMjYHTkA_Y-k4jok1sN4Z-GH1Z1gX8</recordid><startdate>202008</startdate><enddate>202008</enddate><creator>Wang, Tianqi</creator><creator>Wang, Ji</creator><creator>Dou, Yalan</creator><creator>Yan, Weili</creator><creator>Ding, Ding</creator><creator>Lu, Guoping</creator><creator>Ma, Jian</creator><creator>Zhou, Yuanfeng</creator><creator>Li, Taoli</creator><creator>Zhou, Shuizhen</creator><creator>Wang, Yi</creator><general>Elsevier Ltd</general><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>202008</creationdate><title>Clinical characteristics and prognosis in a large paediatric cohort with status epilepticus</title><author>Wang, Tianqi ; Wang, Ji ; Dou, Yalan ; Yan, Weili ; Ding, Ding ; Lu, Guoping ; Ma, Jian ; Zhou, Yuanfeng ; Li, Taoli ; Zhou, Shuizhen ; Wang, Yi</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c389t-6a3ef1956165afc0f647c69415aa93cea355f69a1411868e0649a444b78f7e3e3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><topic>Children</topic><topic>Prognosis</topic><topic>Status epilepticus</topic><topic>Super-refractory status epilepticus</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Wang, Tianqi</creatorcontrib><creatorcontrib>Wang, Ji</creatorcontrib><creatorcontrib>Dou, Yalan</creatorcontrib><creatorcontrib>Yan, Weili</creatorcontrib><creatorcontrib>Ding, Ding</creatorcontrib><creatorcontrib>Lu, Guoping</creatorcontrib><creatorcontrib>Ma, Jian</creatorcontrib><creatorcontrib>Zhou, Yuanfeng</creatorcontrib><creatorcontrib>Li, Taoli</creatorcontrib><creatorcontrib>Zhou, Shuizhen</creatorcontrib><creatorcontrib>Wang, Yi</creatorcontrib><creatorcontrib>the Chinese Paediatric Status Epilepticus Task Force</creatorcontrib><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Seizure (London, England)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Wang, Tianqi</au><au>Wang, Ji</au><au>Dou, Yalan</au><au>Yan, Weili</au><au>Ding, Ding</au><au>Lu, Guoping</au><au>Ma, Jian</au><au>Zhou, Yuanfeng</au><au>Li, Taoli</au><au>Zhou, Shuizhen</au><au>Wang, Yi</au><aucorp>the Chinese Paediatric Status Epilepticus Task Force</aucorp><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Clinical characteristics and prognosis in a large paediatric cohort with status epilepticus</atitle><jtitle>Seizure (London, England)</jtitle><date>2020-08</date><risdate>2020</risdate><volume>80</volume><spage>5</spage><epage>11</epage><pages>5-11</pages><issn>1059-1311</issn><eissn>1532-2688</eissn><abstract>•A nationwide multicenter Chinese study of children with status epilepticus (SE).•Enrolled 4255 inpatient children with SE from 44 hospitals between 2013 and 2015.•Acute symptomatic aetiology was the most common cause of SRSE.•In-hospital mortality rates: 15.2 % (SRSE) and 1.4 % (non-SRSE).•SRSE was factor for in-hospital mortality and short-term neurological dysfunction.
To describe the aetiology, clinical features, and short-term outcomes of children with status epilepticus (SE), in particular super-refractory SE (SRSE), by a nationwide multicentre study in China.
In this retrospective study, inpatient children with SE were identified from neurology departments and paediatric intensive care units from 44 hospitals in 27 provinces of China between 2013 and 2015. Clinical data were exported from the Hospital Information System.
Clinical records from children with SE (n = 4255) aged 1 month to 18 years were enrolled; 13.1 % were diagnosed with SRSE. The most common known SE aetiology was acute symptomatic aetiology (42.8 %) and 50.2 % of SE was caused by epilepsy of unknown aetiology. Acute central nervous system (CNS) infections (38.8 %) were associated with SRSE (P < 0.001). The overall SE in-hospital mortality rate was 3.0 %, which was significantly higher in the children with SRSE than in those with non-SRSE (15.2 % versus 1.4 %, respectively; P < 0.001). Fourteen percent of the children with SE had various levels of neurological dysfunction at discharge. SRSE was a risk factor for in-hospital mortality (hazard ratio = 4.14; 95 % confidence interval [CI]: 2.34−7.32; P < 0.001) and neurological dysfunction at discharge (odds ratio = 2.85; 95 % CI: 1.90−4.27; P < 0.001).
Acute symptomatic aetiology was the most common known cause of paediatric SE. Aetiology was associated with progression to SRSE and short-term neurological dysfunction at discharge. Furthermore, SRSE was considered a risk factor for in-hospital mortality and short-term neurological dysfunction.</abstract><pub>Elsevier Ltd</pub><doi>10.1016/j.seizure.2020.04.001</doi><tpages>7</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Children Prognosis Status epilepticus Super-refractory status epilepticus |
| title | Clinical characteristics and prognosis in a large paediatric cohort with status epilepticus |
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