Design and Synthesis of a Trifunctional Molecular System “Programmed” to Block Epidermal Growth Factor Receptor Tyrosine Kinase, Induce High Levels of DNA Damage, and Inhibit the DNA Repair Enzyme (Poly(ADP-ribose) Polymerase) in Prostate Cancer Cells

Design and Synthesis of a Trifunctional Molecular System “Programmed” to Block Epidermal Growth Factor Receptor Tyrosine Kinase, Induce High Levels of DNA Damage, and Inhibit the DNA Repair Enzyme (Poly(ADP-ribose) Polymerase) in Prostate Cancer Cells

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Veröffentlicht in:Journal of medicinal chemistry 2020-06, Vol.63 (11), p.5752-5762
Hauptverfasser: Schmitt, Julie, Huang, Shanlong, Goodfellow, Elliot, Williams, Christopher, Jean-Claude, Bertrand J.
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container_title Journal of medicinal chemistry
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creator Schmitt, Julie
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Williams, Christopher
Jean-Claude, Bertrand J.
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doi_str_mv 10.1021/acs.jmedchem.9b02008
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title Design and Synthesis of a Trifunctional Molecular System “Programmed” to Block Epidermal Growth Factor Receptor Tyrosine Kinase, Induce High Levels of DNA Damage, and Inhibit the DNA Repair Enzyme (Poly(ADP-ribose) Polymerase) in Prostate Cancer Cells
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