Azithromycin and Diminazene Aceturate Combination Therapy in Experimental Multidrug-resistant Trypanosoma brucei brucei Infection in Albino Rats

•DA-AZT combination therapy in resistant trypanosomal infection was assessed.•Survivability was prolonged in the DA-AZT combination treatment groups.•DA-AZT combination treatment decreased the effect of the infection.•AZT may act as adjunct to DA in treatment of resistant trypanosomal infection. Azi...

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Veröffentlicht in:	Veterinary parasitology 2020-06, Vol.282, p.109138-109138, Article 109138
Hauptverfasser:	Obi, Chukwunonso Francis, Ezeh, Ikenna Onyema, Okpala, Michael Ikenna, Idika, Idika Kalu, Mbe, Nnamdi, Nwobi, Lotanna Gilbert, Ezeokonkwo, Romanus Chukwuduruo
Format:	Artikel
Sprache:	eng
Schlagworte:	Albino rats Animals Azithromycin Azithromycin - pharmacology Diminazene - analogs & derivatives Diminazene - pharmacology Diminazene aceturate Diminazene aceturate-Azithromycin combination Drug Resistance, Multiple Drug Therapy, Combination - veterinary Female Multidrug-resistant Trypanosoma bruceibrucei Rats Trypanocidal Agents - pharmacology Trypanosoma brucei brucei - drug effects
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