Edaravone Improves Intermittent Hypoxia-Induced Cognitive Impairment and Hippocampal Damage in Rats

Oxidative stress plays an essential role in obstructive sleep apnea-hypopnea syndrome-induced cognitive dysfunction in children. This study investigated the effects of edaravone, a potent free radical scavenger, on intermittent hypoxia (IH)-induced oxidative damage and cognition impairment in a youn...

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Veröffentlicht in:	Biological & pharmaceutical bulletin 2020/08/01, Vol.43(8), pp.1196-1201
Hauptverfasser:	Ling, Jizu, Yu, Qin, Li, Yuning, Yuan, Xinhui, Wang, Xiaoya, Liu, Weiying, Guo, Ting, Duan, Yanni, Li, Lifang
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Apnea B-cell lymphoma Brain-derived neurotrophic factor Catalase Cognitive ability Cognitive Dysfunction - drug therapy cognitive function Cyclic AMP - physiology Cyclic AMP response element-binding protein Cyclic AMP Response Element-Binding Protein - physiology Cyclic AMP-Dependent Protein Kinases - physiology Deoxyguanosine edaravone Edaravone - pharmacology Edaravone - therapeutic use Free radicals Hippocampus Hippocampus - drug effects Hippocampus - metabolism Hippocampus - pathology Hypoxia Hypoxia - complications intermittent hypoxia Kinases Lymphocytes B Male Malondialdehyde Manganese Mitochondria Morris Water Maze Test obstructive sleep apnea Oxidative Stress Protein kinase A Rats Rats, Wistar Rodents Sleep Sleep disorders Superoxide dismutase young rat
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