Impact of gastric Helicobacter pylori infection on nasal mucociliary clearance
Objectives This study aimed to investigate the relationship between the presence of gastric Helicobacter pylori (HP) infection and nasal mucociliary clearance (NMC) time and to analyze the effect of HP eradication on NMC time. Materials and methods Patients who underwent gastric biopsy and had a pos...
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| Veröffentlicht in: | European archives of oto-rhino-laryngology 2020-10, Vol.277 (10), p.2761-2765 |
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| creator | Şahin, Ender Katar, Mehmet Kağan Haberal Can, Ilknur |
| description | Objectives
This study aimed to investigate the relationship between the presence of gastric
Helicobacter pylori
(HP) infection and nasal mucociliary clearance (NMC) time and to analyze the effect of HP eradication on NMC time.
Materials and methods
Patients who underwent gastric biopsy and had a positive result for HP constituted the study group, while the control group consisted of the patients who had a negative biopsy result. Two groups were compared in terms of NMC times. Quadruple medication therapy was given to HP-positive patients for 14 days for eradication and NMC time was measured again in these patients 8 weeks after eradication. Statistical analyses were performed with SPSS software (version 22.0; SPSS, Chicago, Illinois, USA).
Results
There were 60 patients in the study group (HP +), while the control group (HP −) included 50 patients. Mean NMC times were 12.86 ± 2.62 and 8.32 ± 2.24 for the study and control groups, respectively (
p
|
| doi_str_mv | 10.1007/s00405-020-06089-2 |
| format | Article |
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This study aimed to investigate the relationship between the presence of gastric
Helicobacter pylori
(HP) infection and nasal mucociliary clearance (NMC) time and to analyze the effect of HP eradication on NMC time.
Materials and methods
Patients who underwent gastric biopsy and had a positive result for HP constituted the study group, while the control group consisted of the patients who had a negative biopsy result. Two groups were compared in terms of NMC times. Quadruple medication therapy was given to HP-positive patients for 14 days for eradication and NMC time was measured again in these patients 8 weeks after eradication. Statistical analyses were performed with SPSS software (version 22.0; SPSS, Chicago, Illinois, USA).
Results
There were 60 patients in the study group (HP +), while the control group (HP −) included 50 patients. Mean NMC times were 12.86 ± 2.62 and 8.32 ± 2.24 for the study and control groups, respectively (
p
< 0.001). Pre- and post-eradication mean NMC times of the HP + patients were 12.71 ± 2.58 and 8.62 ± 1.39, respectively (
p
< 0.001).
Conclusion
We determined that NMC time was significantly higher in HP-positive patients when compared with HP-negative patients, and the NMC times went back to normal after eradicating the HP infection. Because NMC dysfunction plays an essential role in the pathogenesis of chronic rhinosinusitis (CRS), we propose that eradication of HP can have positive effects on the prognosis of CRS. Further studies are needed to establish this relationship.</description><identifier>ISSN: 0937-4477</identifier><identifier>EISSN: 1434-4726</identifier><identifier>DOI: 10.1007/s00405-020-06089-2</identifier><identifier>PMID: 32476044</identifier><language>eng</language><publisher>Berlin/Heidelberg: Springer Berlin Heidelberg</publisher><subject>Anti-Bacterial Agents - therapeutic use ; Biopsy ; Head and Neck Surgery ; Helicobacter Infections - complications ; Helicobacter Infections - drug therapy ; Helicobacter pylori ; Humans ; Medicine ; Medicine & Public Health ; Mucociliary Clearance ; Neurosurgery ; Otorhinolaryngology ; Rhinology ; Stomach</subject><ispartof>European archives of oto-rhino-laryngology, 2020-10, Vol.277 (10), p.2761-2765</ispartof><rights>Springer-Verlag GmbH Germany, part of Springer Nature 2020</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c347t-8af650e9730217998fff5674b1bc4ef43ce9905bf6c94e47641f7e282cd44ee53</citedby><cites>FETCH-LOGICAL-c347t-8af650e9730217998fff5674b1bc4ef43ce9905bf6c94e47641f7e282cd44ee53</cites><orcidid>0000-0002-1599-5456 ; 0000-0002-0798-0393 ; 0000-0002-9944-196X</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s00405-020-06089-2$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s00405-020-06089-2$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,780,784,27924,27925,41488,42557,51319</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/32476044$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Şahin, Ender</creatorcontrib><creatorcontrib>Katar, Mehmet Kağan</creatorcontrib><creatorcontrib>Haberal Can, Ilknur</creatorcontrib><title>Impact of gastric Helicobacter pylori infection on nasal mucociliary clearance</title><title>European archives of oto-rhino-laryngology</title><addtitle>Eur Arch Otorhinolaryngol</addtitle><addtitle>Eur Arch Otorhinolaryngol</addtitle><description>Objectives
This study aimed to investigate the relationship between the presence of gastric
Helicobacter pylori
(HP) infection and nasal mucociliary clearance (NMC) time and to analyze the effect of HP eradication on NMC time.
Materials and methods
Patients who underwent gastric biopsy and had a positive result for HP constituted the study group, while the control group consisted of the patients who had a negative biopsy result. Two groups were compared in terms of NMC times. Quadruple medication therapy was given to HP-positive patients for 14 days for eradication and NMC time was measured again in these patients 8 weeks after eradication. Statistical analyses were performed with SPSS software (version 22.0; SPSS, Chicago, Illinois, USA).
Results
There were 60 patients in the study group (HP +), while the control group (HP −) included 50 patients. Mean NMC times were 12.86 ± 2.62 and 8.32 ± 2.24 for the study and control groups, respectively (
p
< 0.001). Pre- and post-eradication mean NMC times of the HP + patients were 12.71 ± 2.58 and 8.62 ± 1.39, respectively (
p
< 0.001).
Conclusion
We determined that NMC time was significantly higher in HP-positive patients when compared with HP-negative patients, and the NMC times went back to normal after eradicating the HP infection. Because NMC dysfunction plays an essential role in the pathogenesis of chronic rhinosinusitis (CRS), we propose that eradication of HP can have positive effects on the prognosis of CRS. Further studies are needed to establish this relationship.</description><subject>Anti-Bacterial Agents - therapeutic use</subject><subject>Biopsy</subject><subject>Head and Neck Surgery</subject><subject>Helicobacter Infections - complications</subject><subject>Helicobacter Infections - drug therapy</subject><subject>Helicobacter pylori</subject><subject>Humans</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Mucociliary Clearance</subject><subject>Neurosurgery</subject><subject>Otorhinolaryngology</subject><subject>Rhinology</subject><subject>Stomach</subject><issn>0937-4477</issn><issn>1434-4726</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kE9LxDAQxYMo7vrnC3iQHr1Up8m0aY6yqCuIXvQc0jiRSNusSXvYb2901aMwMDDz5vHmx9hZBZcVgLxKAAh1CRxKaKBVJd9jywoFlih5s8-WoIQsEaVcsKOU3gGgRiUO2UJwlA0gLtnj_bAxdiqCK95MmqK3xZp6b0OXpxSLzbYP0Rd-dGQnH8Yi12iS6YthtsH63pu4LWxPJprR0gk7cKZPdPrTj9nL7c3zal0-PN3dr64fSitQTmVrXFMDKSmAV1Kp1jlXNxK7qrNIDoUlpaDuXGMVUs6KlZPEW25fEYlqccwudr6bGD5mSpMefLLU92akMCfNEdpatE1dZSnfSW0MKUVyehP9kFPrCvQXR73jqDNH_c1R83x0_uM_dwO9_p38gssCsROkvBrfKOr3MMcx__yf7Scjbn3v</recordid><startdate>20201001</startdate><enddate>20201001</enddate><creator>Şahin, Ender</creator><creator>Katar, Mehmet Kağan</creator><creator>Haberal Can, Ilknur</creator><general>Springer Berlin Heidelberg</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0002-1599-5456</orcidid><orcidid>https://orcid.org/0000-0002-0798-0393</orcidid><orcidid>https://orcid.org/0000-0002-9944-196X</orcidid></search><sort><creationdate>20201001</creationdate><title>Impact of gastric Helicobacter pylori infection on nasal mucociliary clearance</title><author>Şahin, Ender ; Katar, Mehmet Kağan ; Haberal Can, Ilknur</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c347t-8af650e9730217998fff5674b1bc4ef43ce9905bf6c94e47641f7e282cd44ee53</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><topic>Anti-Bacterial Agents - therapeutic use</topic><topic>Biopsy</topic><topic>Head and Neck Surgery</topic><topic>Helicobacter Infections - complications</topic><topic>Helicobacter Infections - drug therapy</topic><topic>Helicobacter pylori</topic><topic>Humans</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Mucociliary Clearance</topic><topic>Neurosurgery</topic><topic>Otorhinolaryngology</topic><topic>Rhinology</topic><topic>Stomach</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Şahin, Ender</creatorcontrib><creatorcontrib>Katar, Mehmet Kağan</creatorcontrib><creatorcontrib>Haberal Can, Ilknur</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>European archives of oto-rhino-laryngology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Şahin, Ender</au><au>Katar, Mehmet Kağan</au><au>Haberal Can, Ilknur</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Impact of gastric Helicobacter pylori infection on nasal mucociliary clearance</atitle><jtitle>European archives of oto-rhino-laryngology</jtitle><stitle>Eur Arch Otorhinolaryngol</stitle><addtitle>Eur Arch Otorhinolaryngol</addtitle><date>2020-10-01</date><risdate>2020</risdate><volume>277</volume><issue>10</issue><spage>2761</spage><epage>2765</epage><pages>2761-2765</pages><issn>0937-4477</issn><eissn>1434-4726</eissn><abstract>Objectives
This study aimed to investigate the relationship between the presence of gastric
Helicobacter pylori
(HP) infection and nasal mucociliary clearance (NMC) time and to analyze the effect of HP eradication on NMC time.
Materials and methods
Patients who underwent gastric biopsy and had a positive result for HP constituted the study group, while the control group consisted of the patients who had a negative biopsy result. Two groups were compared in terms of NMC times. Quadruple medication therapy was given to HP-positive patients for 14 days for eradication and NMC time was measured again in these patients 8 weeks after eradication. Statistical analyses were performed with SPSS software (version 22.0; SPSS, Chicago, Illinois, USA).
Results
There were 60 patients in the study group (HP +), while the control group (HP −) included 50 patients. Mean NMC times were 12.86 ± 2.62 and 8.32 ± 2.24 for the study and control groups, respectively (
p
< 0.001). Pre- and post-eradication mean NMC times of the HP + patients were 12.71 ± 2.58 and 8.62 ± 1.39, respectively (
p
< 0.001).
Conclusion
We determined that NMC time was significantly higher in HP-positive patients when compared with HP-negative patients, and the NMC times went back to normal after eradicating the HP infection. Because NMC dysfunction plays an essential role in the pathogenesis of chronic rhinosinusitis (CRS), we propose that eradication of HP can have positive effects on the prognosis of CRS. Further studies are needed to establish this relationship.</abstract><cop>Berlin/Heidelberg</cop><pub>Springer Berlin Heidelberg</pub><pmid>32476044</pmid><doi>10.1007/s00405-020-06089-2</doi><tpages>5</tpages><orcidid>https://orcid.org/0000-0002-1599-5456</orcidid><orcidid>https://orcid.org/0000-0002-0798-0393</orcidid><orcidid>https://orcid.org/0000-0002-9944-196X</orcidid></addata></record> |
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| language | eng |
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| source | MEDLINE; SpringerNature Journals |
| subjects | Anti-Bacterial Agents - therapeutic use Biopsy Head and Neck Surgery Helicobacter Infections - complications Helicobacter Infections - drug therapy Helicobacter pylori Humans Medicine Medicine & Public Health Mucociliary Clearance Neurosurgery Otorhinolaryngology Rhinology Stomach |
| title | Impact of gastric Helicobacter pylori infection on nasal mucociliary clearance |
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