Pd-Catalyzed Dearomative Asymmetric Allylic Alkylation of Naphthols with Alkoxyallenes

Pd-Catalyzed Dearomative Asymmetric Allylic Alkylation of Naphthols with Alkoxyallenes

An Pd-catalyzed linear selective intermolecular asymmetric dearomative allylic alkylation reaction of naphthols with alkoxyallenes under mild reaction conditions is reported. The transformation is successfully promoted by Pd2(dba)3 and chiral Trost ligand, and provides a general atom-efficient proto...

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Veröffentlicht in:Journal of organic chemistry 2020-06, Vol.85 (12), p.7896-7904
Hauptverfasser: Hu, Jinjin, Pan, Shulei, Zhu, Shuai, Yu, Peiyuan, Xu, Ruigang, Zhong, Guofu, Zeng, Xiaofei
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container_end_page 7904
container_issue 12
container_start_page 7896
container_title Journal of organic chemistry
container_volume 85
creator Hu, Jinjin
Pan, Shulei
Zhu, Shuai
Yu, Peiyuan
Xu, Ruigang
Zhong, Guofu
Zeng, Xiaofei
description An Pd-catalyzed linear selective intermolecular asymmetric dearomative allylic alkylation reaction of naphthols with alkoxyallenes under mild reaction conditions is reported. The transformation is successfully promoted by Pd2(dba)3 and chiral Trost ligand, and provides a general atom-efficient protocol to obtain various β-naphthalenones bearing an all carbon quaternary stereogenic center in good yields, chemo- and stereoselectivities.
doi_str_mv 10.1021/acs.joc.0c00582
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title Pd-Catalyzed Dearomative Asymmetric Allylic Alkylation of Naphthols with Alkoxyallenes
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