Relationship between the severity of Helicobacter pylori infection and neutrophil and lymphocyte ratio and mean platelet volume in children
HP causes local inflammation in the stomach and a systemic humoral immune response. No relationship was found in adult studies investigating the association between HP infection and neutrophil/lymphocyte ratio (NLR) and mean platelet volume (MPV). To our knowledge, there is no study in children. We...
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| Veröffentlicht in: | Archivos argentinos de pediatría 2020-06, Vol.118 (3), p.e241-e245 |
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| container_title | Archivos argentinos de pediatría |
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| creator | Sahin, Yasin Gubur, Ozlem Tekingunduz, Emine |
| description | HP causes local inflammation in the stomach and a systemic humoral immune response. No relationship was found in adult studies investigating the association between HP infection and neutrophil/lymphocyte ratio (NLR) and mean platelet volume (MPV). To our knowledge, there is no study in children. We aimed to evaluate the association between NLR and MPV values with HP infection, severity classification, and pre- and post-treatment status.
Patients with dyspepsia aged between 2-18 years and without any chronic diseases undergoing gastroduodenoscopy were included in the study. Endoscopic mucosal biopsy was performed, HP presence and infection severity were determined according to Sydney Classification.
153 patients with HP positivity and 211 patients with HP negativity were included in the study, the mean age of them was 13.3 ± 3.4 years and 13.1 ± 3.5 years, respectively. No statistically significant difference was found between patients with HP positive and negative patients and also between severity subgroups of HP positive patients in terms of NLR and MPV (p > 0.05).
There was no association between NLR and MPV values with HP infection, severity classification, or pre- and post-treatment status. |
| doi_str_mv | 10.5546/aap.2020.eng.e241 |
| format | Article |
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Patients with dyspepsia aged between 2-18 years and without any chronic diseases undergoing gastroduodenoscopy were included in the study. Endoscopic mucosal biopsy was performed, HP presence and infection severity were determined according to Sydney Classification.
153 patients with HP positivity and 211 patients with HP negativity were included in the study, the mean age of them was 13.3 ± 3.4 years and 13.1 ± 3.5 years, respectively. No statistically significant difference was found between patients with HP positive and negative patients and also between severity subgroups of HP positive patients in terms of NLR and MPV (p > 0.05).
There was no association between NLR and MPV values with HP infection, severity classification, or pre- and post-treatment status.</description><identifier>ISSN: 0325-0075</identifier><identifier>EISSN: 1668-3501</identifier><identifier>DOI: 10.5546/aap.2020.eng.e241</identifier><identifier>PMID: 32470257</identifier><language>eng</language><publisher>Argentina</publisher><subject>Adolescent ; Biomarkers - blood ; Blood Platelets - metabolism ; Child ; Child, Preschool ; Cross-Sectional Studies ; Duodenoscopy ; Female ; Gastroscopy ; Helicobacter Infections - blood ; Helicobacter Infections - diagnosis ; Helicobacter Infections - immunology ; Helicobacter pylori - isolation & purification ; Humans ; Lymphocytes - metabolism ; Male ; Neutrophils - metabolism ; Severity of Illness Index</subject><ispartof>Archivos argentinos de pediatría, 2020-06, Vol.118 (3), p.e241-e245</ispartof><rights>Sociedad Argentina de Pediatría.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c344t-2cf0f2adc3488fe8be3cfe38e0e99595d30f8a90715cd48c2d1de39005aa4b723</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/32470257$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Sahin, Yasin</creatorcontrib><creatorcontrib>Gubur, Ozlem</creatorcontrib><creatorcontrib>Tekingunduz, Emine</creatorcontrib><title>Relationship between the severity of Helicobacter pylori infection and neutrophil and lymphocyte ratio and mean platelet volume in children</title><title>Archivos argentinos de pediatría</title><addtitle>Arch Argent Pediatr</addtitle><description>HP causes local inflammation in the stomach and a systemic humoral immune response. No relationship was found in adult studies investigating the association between HP infection and neutrophil/lymphocyte ratio (NLR) and mean platelet volume (MPV). To our knowledge, there is no study in children. We aimed to evaluate the association between NLR and MPV values with HP infection, severity classification, and pre- and post-treatment status.
Patients with dyspepsia aged between 2-18 years and without any chronic diseases undergoing gastroduodenoscopy were included in the study. Endoscopic mucosal biopsy was performed, HP presence and infection severity were determined according to Sydney Classification.
153 patients with HP positivity and 211 patients with HP negativity were included in the study, the mean age of them was 13.3 ± 3.4 years and 13.1 ± 3.5 years, respectively. No statistically significant difference was found between patients with HP positive and negative patients and also between severity subgroups of HP positive patients in terms of NLR and MPV (p > 0.05).
There was no association between NLR and MPV values with HP infection, severity classification, or pre- and post-treatment status.</description><subject>Adolescent</subject><subject>Biomarkers - blood</subject><subject>Blood Platelets - metabolism</subject><subject>Child</subject><subject>Child, Preschool</subject><subject>Cross-Sectional Studies</subject><subject>Duodenoscopy</subject><subject>Female</subject><subject>Gastroscopy</subject><subject>Helicobacter Infections - blood</subject><subject>Helicobacter Infections - diagnosis</subject><subject>Helicobacter Infections - immunology</subject><subject>Helicobacter pylori - isolation & purification</subject><subject>Humans</subject><subject>Lymphocytes - metabolism</subject><subject>Male</subject><subject>Neutrophils - metabolism</subject><subject>Severity of Illness Index</subject><issn>0325-0075</issn><issn>1668-3501</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNo9kc1u1TAQhS0EopfCA7BBXrLJ7fjvJlmiCihSpUoI1pbjjLlGjh1spyjPwEuTtIXV6IzOOSPNR8hbBkel5OnKmPnIgcMR448jcsmekQM7nbpGKGDPyQEEVw1Aqy7Iq1J-Akgh-vYluRBctsBVeyB_vmIw1adYzn6mA9bfiJHWM9KC95h9XWly9AaDt2kwtmKm8xpS9tRHh3ZPUhNHGnGpOc1nHx5kWKf5nOxakea9_mE5oYl03s5hwErvU1gm3Gqo3VJjxviavHAmFHzzNC_J908fv13fNLd3n79cf7htrJCyNtw6cNyMm-o6h92AwjoUHQL2verVKMB1poeWKTvKzvKRjSh6AGWMHFouLsn7x945p18LlqonXyyGYCKmpWguoWN9L9rTZmWPVptTKRmdnrOfTF41A70z0BsDvTPQGwO9M9gy757ql2HC8X_i39PFX8BViCw</recordid><startdate>202006</startdate><enddate>202006</enddate><creator>Sahin, Yasin</creator><creator>Gubur, Ozlem</creator><creator>Tekingunduz, Emine</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>202006</creationdate><title>Relationship between the severity of Helicobacter pylori infection and neutrophil and lymphocyte ratio and mean platelet volume in children</title><author>Sahin, Yasin ; Gubur, Ozlem ; Tekingunduz, Emine</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c344t-2cf0f2adc3488fe8be3cfe38e0e99595d30f8a90715cd48c2d1de39005aa4b723</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><topic>Adolescent</topic><topic>Biomarkers - blood</topic><topic>Blood Platelets - metabolism</topic><topic>Child</topic><topic>Child, Preschool</topic><topic>Cross-Sectional Studies</topic><topic>Duodenoscopy</topic><topic>Female</topic><topic>Gastroscopy</topic><topic>Helicobacter Infections - blood</topic><topic>Helicobacter Infections - diagnosis</topic><topic>Helicobacter Infections - immunology</topic><topic>Helicobacter pylori - isolation & purification</topic><topic>Humans</topic><topic>Lymphocytes - metabolism</topic><topic>Male</topic><topic>Neutrophils - metabolism</topic><topic>Severity of Illness Index</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Sahin, Yasin</creatorcontrib><creatorcontrib>Gubur, Ozlem</creatorcontrib><creatorcontrib>Tekingunduz, Emine</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Archivos argentinos de pediatría</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Sahin, Yasin</au><au>Gubur, Ozlem</au><au>Tekingunduz, Emine</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Relationship between the severity of Helicobacter pylori infection and neutrophil and lymphocyte ratio and mean platelet volume in children</atitle><jtitle>Archivos argentinos de pediatría</jtitle><addtitle>Arch Argent Pediatr</addtitle><date>2020-06</date><risdate>2020</risdate><volume>118</volume><issue>3</issue><spage>e241</spage><epage>e245</epage><pages>e241-e245</pages><issn>0325-0075</issn><eissn>1668-3501</eissn><abstract>HP causes local inflammation in the stomach and a systemic humoral immune response. No relationship was found in adult studies investigating the association between HP infection and neutrophil/lymphocyte ratio (NLR) and mean platelet volume (MPV). To our knowledge, there is no study in children. We aimed to evaluate the association between NLR and MPV values with HP infection, severity classification, and pre- and post-treatment status.
Patients with dyspepsia aged between 2-18 years and without any chronic diseases undergoing gastroduodenoscopy were included in the study. Endoscopic mucosal biopsy was performed, HP presence and infection severity were determined according to Sydney Classification.
153 patients with HP positivity and 211 patients with HP negativity were included in the study, the mean age of them was 13.3 ± 3.4 years and 13.1 ± 3.5 years, respectively. No statistically significant difference was found between patients with HP positive and negative patients and also between severity subgroups of HP positive patients in terms of NLR and MPV (p > 0.05).
There was no association between NLR and MPV values with HP infection, severity classification, or pre- and post-treatment status.</abstract><cop>Argentina</cop><pmid>32470257</pmid><doi>10.5546/aap.2020.eng.e241</doi><oa>free_for_read</oa></addata></record> |
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| ispartof | Archivos argentinos de pediatría, 2020-06, Vol.118 (3), p.e241-e245 |
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| language | eng |
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| source | MEDLINE; EZB-FREE-00999 freely available EZB journals |
| subjects | Adolescent Biomarkers - blood Blood Platelets - metabolism Child Child, Preschool Cross-Sectional Studies Duodenoscopy Female Gastroscopy Helicobacter Infections - blood Helicobacter Infections - diagnosis Helicobacter Infections - immunology Helicobacter pylori - isolation & purification Humans Lymphocytes - metabolism Male Neutrophils - metabolism Severity of Illness Index |
| title | Relationship between the severity of Helicobacter pylori infection and neutrophil and lymphocyte ratio and mean platelet volume in children |
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