Dichloroacetate prevents TGFβ-induced epithelial-mesenchymal transition of retinal pigment epithelial cells

Proliferative retinopathies are associated with formation of fibrous epiretinal membranes. At present, there is no pharmacological intervention for the treatment of retinopathies. Cytokines such as TGFβ are elevated in the vitreous humor of the patients with proliferative vitro-retinopathy, diabetic...

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Veröffentlicht in:	Experimental eye research 2020-08, Vol.197, p.108072-108072, Article 108072
Hauptverfasser:	Shukal, Dhaval, Bhadresha, Kinjal, Shastri, Bhoomi, Mehta, Deval, Vasavada, Abhay, Johar SR, Kaid
Format:	Artikel
Sprache:	eng
Schlagworte:	ARPE-19 Blotting, Western Cell Differentiation Cell Line Cell Movement Dichloroacetate Dichloroacetic Acid - pharmacology Epithelial-mesenchymal transition Epithelial-Mesenchymal Transition - drug effects Humans MAPK/Erk pathway PI3K/Akt pathway Proliferative retinopathies Retinal pigment epithelium Retinal Pigment Epithelium - drug effects Retinal Pigment Epithelium - metabolism Retinal Pigment Epithelium - pathology Signal Transduction TGFβ Transforming Growth Factor beta2 - metabolism Vitreoretinopathy, Proliferative - metabolism Vitreoretinopathy, Proliferative - pathology
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