Neuroprotection by curcumin: A review on brain delivery strategies
[Display omitted] Neurodegenerative diseases are a major global public health concern in the elderly population but therapeutic options are limited. Curcumin is a hydrophobic polyphenol extracted from the dried rhizomes of Curcuma longa L. and shows good potential for the treatment of neurodegenerat...
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| Veröffentlicht in: | International journal of pharmaceutics 2020-07, Vol.585, p.119476-119476, Article 119476 |
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| container_title | International journal of pharmaceutics |
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| creator | Askarizadeh, Anis Barreto, George E. Henney, Neil C. Majeed, Muhammed Sahebkar, Amirhossein |
| description | [Display omitted]
Neurodegenerative diseases are a major global public health concern in the elderly population but therapeutic options are limited. Curcumin is a hydrophobic polyphenol extracted from the dried rhizomes of Curcuma longa L. and shows good potential for the treatment of neurodegenerative diseases and brain tumors. The blood–brain barrier (BBB) is the major obstacle for the delivery of curcumin into the brain, limiting its therapeutic potential. The development of promising approaches to facilitate curcumin transportation across the BBB may resolve some of the problems associated with drug delivery. Studies have shown nano delivery of curcumin can improve a number of outcome measures in neurodegenerative diseases. The present review highlights current and emerging strategies to facilitate curcumin permeation across the BBB for the treatment of various neurodegenerative diseases. |
| doi_str_mv | 10.1016/j.ijpharm.2020.119476 |
| format | Article |
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Neurodegenerative diseases are a major global public health concern in the elderly population but therapeutic options are limited. Curcumin is a hydrophobic polyphenol extracted from the dried rhizomes of Curcuma longa L. and shows good potential for the treatment of neurodegenerative diseases and brain tumors. The blood–brain barrier (BBB) is the major obstacle for the delivery of curcumin into the brain, limiting its therapeutic potential. The development of promising approaches to facilitate curcumin transportation across the BBB may resolve some of the problems associated with drug delivery. Studies have shown nano delivery of curcumin can improve a number of outcome measures in neurodegenerative diseases. The present review highlights current and emerging strategies to facilitate curcumin permeation across the BBB for the treatment of various neurodegenerative diseases.</description><identifier>ISSN: 0378-5173</identifier><identifier>EISSN: 1873-3476</identifier><identifier>DOI: 10.1016/j.ijpharm.2020.119476</identifier><identifier>PMID: 32473377</identifier><language>eng</language><publisher>Netherlands: Elsevier B.V</publisher><subject>Animals ; Anti-Inflammatory Agents, Non-Steroidal - administration & dosage ; Anti-Inflammatory Agents, Non-Steroidal - metabolism ; Blood-brain barrier ; Blood-Brain Barrier - drug effects ; Blood-Brain Barrier - metabolism ; Brain - drug effects ; Brain - metabolism ; Curcumin ; Curcumin - administration & dosage ; Curcumin - metabolism ; Drug delivery ; Drug Delivery Systems - methods ; Humans ; Nanotechnology ; Neurodegeneration ; Neurodegenerative Diseases - drug therapy ; Neurodegenerative Diseases - metabolism ; Neuroprotection - drug effects ; Neuroprotection - physiology</subject><ispartof>International journal of pharmaceutics, 2020-07, Vol.585, p.119476-119476, Article 119476</ispartof><rights>2020 Elsevier B.V.</rights><rights>Copyright © 2020 Elsevier B.V. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c431t-46d0222e3f0c6394d3f06c92f7c78367735f7a4987181b2a83c45a432c9b0e4a3</citedby><cites>FETCH-LOGICAL-c431t-46d0222e3f0c6394d3f06c92f7c78367735f7a4987181b2a83c45a432c9b0e4a3</cites><orcidid>0000-0002-6644-1971</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.ijpharm.2020.119476$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3541,27915,27916,45986</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/32473377$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Askarizadeh, Anis</creatorcontrib><creatorcontrib>Barreto, George E.</creatorcontrib><creatorcontrib>Henney, Neil C.</creatorcontrib><creatorcontrib>Majeed, Muhammed</creatorcontrib><creatorcontrib>Sahebkar, Amirhossein</creatorcontrib><title>Neuroprotection by curcumin: A review on brain delivery strategies</title><title>International journal of pharmaceutics</title><addtitle>Int J Pharm</addtitle><description>[Display omitted]
Neurodegenerative diseases are a major global public health concern in the elderly population but therapeutic options are limited. Curcumin is a hydrophobic polyphenol extracted from the dried rhizomes of Curcuma longa L. and shows good potential for the treatment of neurodegenerative diseases and brain tumors. The blood–brain barrier (BBB) is the major obstacle for the delivery of curcumin into the brain, limiting its therapeutic potential. The development of promising approaches to facilitate curcumin transportation across the BBB may resolve some of the problems associated with drug delivery. Studies have shown nano delivery of curcumin can improve a number of outcome measures in neurodegenerative diseases. 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Neurodegenerative diseases are a major global public health concern in the elderly population but therapeutic options are limited. Curcumin is a hydrophobic polyphenol extracted from the dried rhizomes of Curcuma longa L. and shows good potential for the treatment of neurodegenerative diseases and brain tumors. The blood–brain barrier (BBB) is the major obstacle for the delivery of curcumin into the brain, limiting its therapeutic potential. The development of promising approaches to facilitate curcumin transportation across the BBB may resolve some of the problems associated with drug delivery. Studies have shown nano delivery of curcumin can improve a number of outcome measures in neurodegenerative diseases. The present review highlights current and emerging strategies to facilitate curcumin permeation across the BBB for the treatment of various neurodegenerative diseases.</abstract><cop>Netherlands</cop><pub>Elsevier B.V</pub><pmid>32473377</pmid><doi>10.1016/j.ijpharm.2020.119476</doi><tpages>1</tpages><orcidid>https://orcid.org/0000-0002-6644-1971</orcidid></addata></record> |
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| ispartof | International journal of pharmaceutics, 2020-07, Vol.585, p.119476-119476, Article 119476 |
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| source | MEDLINE; ScienceDirect Journals (5 years ago - present) |
| subjects | Animals Anti-Inflammatory Agents, Non-Steroidal - administration & dosage Anti-Inflammatory Agents, Non-Steroidal - metabolism Blood-brain barrier Blood-Brain Barrier - drug effects Blood-Brain Barrier - metabolism Brain - drug effects Brain - metabolism Curcumin Curcumin - administration & dosage Curcumin - metabolism Drug delivery Drug Delivery Systems - methods Humans Nanotechnology Neurodegeneration Neurodegenerative Diseases - drug therapy Neurodegenerative Diseases - metabolism Neuroprotection - drug effects Neuroprotection - physiology |
| title | Neuroprotection by curcumin: A review on brain delivery strategies |
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