UCP1 regulates ALDH-positive breast cancer stem cells through releasing the suppression of Snail on FBP1
Uncoupling protein 1 (UCP1) has been implicated in ameliorating metabolic related disorders, of which most symptoms are risk factors for breast cancer. Here, we found that UCP1 was obviously downregulated in basal-like breast cancer (BLBC) and was positively correlated with improved survival. Howeve...
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| Veröffentlicht in: | Cell biology and toxicology 2021-04, Vol.37 (2), p.277-291 |
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| creator | Zhang, Fuchuang Liu, Bingjie Deng, Qiaodan Sheng, Dandan Xu, Jiahui He, Xueyan Zhang, Lixing Liu, Suling |
| description | Uncoupling protein 1 (UCP1) has been implicated in ameliorating metabolic related disorders, of which most symptoms are risk factors for breast cancer. Here, we found that UCP1 was obviously downregulated in basal-like breast cancer (BLBC) and was positively correlated with improved survival. However, the underlying regulatory mechanisms remain largely unknown. Our studies showed that UCP1 inhibited tumor progression via suppressing aldehyde dehydrogenase (ALDH)-positive breast cancer stem cell (BCSC) population in BLBC. Furthermore, we found that UCP1 induced the upregulation of fructose bisphosphatase 1 (FBP1) which was previously blocked by Snail overexpression, and UCP1 decreased ALDH-positive BCSCs via FBP1-dependent metabolic rewiring, which could be reversed by Snail overexpression. In addition, breast cancer cells co-cultured with UCP1-deficient adipocytes had increased proportion of ALDH-positive BCSCs, indicating a potential protection role of UCP1 in tumor microenvironment. These results suggested that UCP1 suppressed BCSCs through inhibiting Snail-mediated repression of FBP1, and that upregulation of UCP1 might be a previously undescribed therapeutic strategy for combating breast cancer.
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| doi_str_mv | 10.1007/s10565-020-09533-5 |
| format | Article |
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Graphical abstract</description><identifier>ISSN: 0742-2091</identifier><identifier>EISSN: 1573-6822</identifier><identifier>DOI: 10.1007/s10565-020-09533-5</identifier><identifier>PMID: 32472219</identifier><language>eng</language><publisher>Dordrecht: Springer Netherlands</publisher><subject>Adipocytes ; Adipocytes - metabolism ; Aldehyde dehydrogenase ; Aldehyde Dehydrogenase - metabolism ; Aldehydes ; Biochemistry ; Biomedical and Life Sciences ; Breast cancer ; Breast Neoplasms - metabolism ; Breast Neoplasms - pathology ; Carcinogenesis - metabolism ; Carcinogenesis - pathology ; Cell Biology ; Cell Line, Tumor ; Cell Movement ; Cell Proliferation ; Disease Progression ; Female ; Fructose-Bisphosphatase - metabolism ; Glycolysis ; Humans ; Life Sciences ; Metabolism ; Neoplasm Invasiveness ; Neoplastic Stem Cells - metabolism ; Neoplastic Stem Cells - pathology ; Original Article ; Pharmacology/Toxicology ; Regulatory mechanisms (biology) ; Rewiring ; Risk analysis ; Risk factors ; Signs and symptoms ; Snail Family Transcription Factors - metabolism ; Stem cells ; Survival Analysis ; Tumor microenvironment ; Tumors ; Uncoupling protein 1 ; Uncoupling Protein 1 - deficiency ; Uncoupling Protein 1 - metabolism ; Up-Regulation</subject><ispartof>Cell biology and toxicology, 2021-04, Vol.37 (2), p.277-291</ispartof><rights>Springer Nature B.V. 2020</rights><rights>Springer Nature B.V. 2020.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c375t-95935e01287a4bac1ac9612ef50ee272d2404c07448cd413601a192fcefb4b4e3</citedby><cites>FETCH-LOGICAL-c375t-95935e01287a4bac1ac9612ef50ee272d2404c07448cd413601a192fcefb4b4e3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s10565-020-09533-5$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s10565-020-09533-5$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,777,781,27905,27906,41469,42538,51300</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/32472219$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Zhang, Fuchuang</creatorcontrib><creatorcontrib>Liu, Bingjie</creatorcontrib><creatorcontrib>Deng, Qiaodan</creatorcontrib><creatorcontrib>Sheng, Dandan</creatorcontrib><creatorcontrib>Xu, Jiahui</creatorcontrib><creatorcontrib>He, Xueyan</creatorcontrib><creatorcontrib>Zhang, Lixing</creatorcontrib><creatorcontrib>Liu, Suling</creatorcontrib><title>UCP1 regulates ALDH-positive breast cancer stem cells through releasing the suppression of Snail on FBP1</title><title>Cell biology and toxicology</title><addtitle>Cell Biol Toxicol</addtitle><addtitle>Cell Biol Toxicol</addtitle><description>Uncoupling protein 1 (UCP1) has been implicated in ameliorating metabolic related disorders, of which most symptoms are risk factors for breast cancer. Here, we found that UCP1 was obviously downregulated in basal-like breast cancer (BLBC) and was positively correlated with improved survival. However, the underlying regulatory mechanisms remain largely unknown. Our studies showed that UCP1 inhibited tumor progression via suppressing aldehyde dehydrogenase (ALDH)-positive breast cancer stem cell (BCSC) population in BLBC. Furthermore, we found that UCP1 induced the upregulation of fructose bisphosphatase 1 (FBP1) which was previously blocked by Snail overexpression, and UCP1 decreased ALDH-positive BCSCs via FBP1-dependent metabolic rewiring, which could be reversed by Snail overexpression. In addition, breast cancer cells co-cultured with UCP1-deficient adipocytes had increased proportion of ALDH-positive BCSCs, indicating a potential protection role of UCP1 in tumor microenvironment. These results suggested that UCP1 suppressed BCSCs through inhibiting Snail-mediated repression of FBP1, and that upregulation of UCP1 might be a previously undescribed therapeutic strategy for combating breast cancer.
Graphical abstract</description><subject>Adipocytes</subject><subject>Adipocytes - metabolism</subject><subject>Aldehyde dehydrogenase</subject><subject>Aldehyde Dehydrogenase - metabolism</subject><subject>Aldehydes</subject><subject>Biochemistry</subject><subject>Biomedical and Life Sciences</subject><subject>Breast cancer</subject><subject>Breast Neoplasms - metabolism</subject><subject>Breast Neoplasms - pathology</subject><subject>Carcinogenesis - metabolism</subject><subject>Carcinogenesis - pathology</subject><subject>Cell Biology</subject><subject>Cell Line, Tumor</subject><subject>Cell Movement</subject><subject>Cell Proliferation</subject><subject>Disease Progression</subject><subject>Female</subject><subject>Fructose-Bisphosphatase - metabolism</subject><subject>Glycolysis</subject><subject>Humans</subject><subject>Life Sciences</subject><subject>Metabolism</subject><subject>Neoplasm Invasiveness</subject><subject>Neoplastic Stem Cells - metabolism</subject><subject>Neoplastic Stem Cells - pathology</subject><subject>Original Article</subject><subject>Pharmacology/Toxicology</subject><subject>Regulatory mechanisms (biology)</subject><subject>Rewiring</subject><subject>Risk analysis</subject><subject>Risk factors</subject><subject>Signs and symptoms</subject><subject>Snail Family Transcription Factors - metabolism</subject><subject>Stem cells</subject><subject>Survival Analysis</subject><subject>Tumor microenvironment</subject><subject>Tumors</subject><subject>Uncoupling protein 1</subject><subject>Uncoupling Protein 1 - deficiency</subject><subject>Uncoupling Protein 1 - metabolism</subject><subject>Up-Regulation</subject><issn>0742-2091</issn><issn>1573-6822</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNp9kU1v1DAQhq0KRJctf6CHyhIXLobxV5wc2y1tkVaiEu3ZcryT3VTZJHiSSvx7XLYFqQdOtuznmRn7ZexUwmcJ4L6QBFtYAQoEVFZrYY_YQlqnRVEq9YYtwBklFFTymL0negCAQjr7jh1rZZxSslqw3f3qVvKE27kLExI_X1_eiHGgdmofkdcJA008hj5i4jThnkfsOuLTLg3zdpfFLhNtv80nyGkex4RE7dDzoeE_-tB2PO-vLm7lCXvbhI7ww_O6ZPdXX-9WN2L9_frb6nwtonZ2EpWttEWQqnTB1CHKEKtCKmwsICqnNsqAiflhpowbI3UBMshKNRGb2tQG9ZJ9OtQd0_BzRpr8vqWnoUOPw0w--2UWZHaX7OMr9GGYU5-n88qC07ZwRZkpdaBiGogSNn5M7T6kX16Cf8rBH3LwOQf_Jwdvs3T2XHqu97j5q7x8fAb0AaB81W8x_ev9n7K_Aah0kYA</recordid><startdate>20210401</startdate><enddate>20210401</enddate><creator>Zhang, Fuchuang</creator><creator>Liu, Bingjie</creator><creator>Deng, Qiaodan</creator><creator>Sheng, Dandan</creator><creator>Xu, Jiahui</creator><creator>He, Xueyan</creator><creator>Zhang, Lixing</creator><creator>Liu, Suling</creator><general>Springer Netherlands</general><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7RV</scope><scope>7TK</scope><scope>7TM</scope><scope>7U7</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>88I</scope><scope>8AO</scope><scope>8C1</scope><scope>8FD</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AEUYN</scope><scope>AFKRA</scope><scope>ATCPS</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>C1K</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>KB0</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M2P</scope><scope>M7P</scope><scope>NAPCQ</scope><scope>P64</scope><scope>PATMY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PYCSY</scope><scope>Q9U</scope><scope>RC3</scope><scope>7X8</scope></search><sort><creationdate>20210401</creationdate><title>UCP1 regulates ALDH-positive breast cancer stem cells through releasing the suppression of Snail on FBP1</title><author>Zhang, Fuchuang ; Liu, Bingjie ; Deng, Qiaodan ; Sheng, Dandan ; Xu, Jiahui ; He, Xueyan ; Zhang, Lixing ; Liu, Suling</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c375t-95935e01287a4bac1ac9612ef50ee272d2404c07448cd413601a192fcefb4b4e3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>Adipocytes</topic><topic>Adipocytes - metabolism</topic><topic>Aldehyde dehydrogenase</topic><topic>Aldehyde Dehydrogenase - metabolism</topic><topic>Aldehydes</topic><topic>Biochemistry</topic><topic>Biomedical and Life Sciences</topic><topic>Breast cancer</topic><topic>Breast Neoplasms - metabolism</topic><topic>Breast Neoplasms - pathology</topic><topic>Carcinogenesis - metabolism</topic><topic>Carcinogenesis - pathology</topic><topic>Cell Biology</topic><topic>Cell Line, Tumor</topic><topic>Cell Movement</topic><topic>Cell Proliferation</topic><topic>Disease Progression</topic><topic>Female</topic><topic>Fructose-Bisphosphatase - metabolism</topic><topic>Glycolysis</topic><topic>Humans</topic><topic>Life Sciences</topic><topic>Metabolism</topic><topic>Neoplasm Invasiveness</topic><topic>Neoplastic Stem Cells - metabolism</topic><topic>Neoplastic Stem Cells - pathology</topic><topic>Original Article</topic><topic>Pharmacology/Toxicology</topic><topic>Regulatory mechanisms (biology)</topic><topic>Rewiring</topic><topic>Risk analysis</topic><topic>Risk factors</topic><topic>Signs and symptoms</topic><topic>Snail Family Transcription Factors - 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Academic</collection><jtitle>Cell biology and toxicology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Zhang, Fuchuang</au><au>Liu, Bingjie</au><au>Deng, Qiaodan</au><au>Sheng, Dandan</au><au>Xu, Jiahui</au><au>He, Xueyan</au><au>Zhang, Lixing</au><au>Liu, Suling</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>UCP1 regulates ALDH-positive breast cancer stem cells through releasing the suppression of Snail on FBP1</atitle><jtitle>Cell biology and toxicology</jtitle><stitle>Cell Biol Toxicol</stitle><addtitle>Cell Biol Toxicol</addtitle><date>2021-04-01</date><risdate>2021</risdate><volume>37</volume><issue>2</issue><spage>277</spage><epage>291</epage><pages>277-291</pages><issn>0742-2091</issn><eissn>1573-6822</eissn><abstract>Uncoupling protein 1 (UCP1) has been implicated in ameliorating metabolic related disorders, of which most symptoms are risk factors for breast cancer. Here, we found that UCP1 was obviously downregulated in basal-like breast cancer (BLBC) and was positively correlated with improved survival. However, the underlying regulatory mechanisms remain largely unknown. Our studies showed that UCP1 inhibited tumor progression via suppressing aldehyde dehydrogenase (ALDH)-positive breast cancer stem cell (BCSC) population in BLBC. Furthermore, we found that UCP1 induced the upregulation of fructose bisphosphatase 1 (FBP1) which was previously blocked by Snail overexpression, and UCP1 decreased ALDH-positive BCSCs via FBP1-dependent metabolic rewiring, which could be reversed by Snail overexpression. In addition, breast cancer cells co-cultured with UCP1-deficient adipocytes had increased proportion of ALDH-positive BCSCs, indicating a potential protection role of UCP1 in tumor microenvironment. These results suggested that UCP1 suppressed BCSCs through inhibiting Snail-mediated repression of FBP1, and that upregulation of UCP1 might be a previously undescribed therapeutic strategy for combating breast cancer.
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| subjects | Adipocytes Adipocytes - metabolism Aldehyde dehydrogenase Aldehyde Dehydrogenase - metabolism Aldehydes Biochemistry Biomedical and Life Sciences Breast cancer Breast Neoplasms - metabolism Breast Neoplasms - pathology Carcinogenesis - metabolism Carcinogenesis - pathology Cell Biology Cell Line, Tumor Cell Movement Cell Proliferation Disease Progression Female Fructose-Bisphosphatase - metabolism Glycolysis Humans Life Sciences Metabolism Neoplasm Invasiveness Neoplastic Stem Cells - metabolism Neoplastic Stem Cells - pathology Original Article Pharmacology/Toxicology Regulatory mechanisms (biology) Rewiring Risk analysis Risk factors Signs and symptoms Snail Family Transcription Factors - metabolism Stem cells Survival Analysis Tumor microenvironment Tumors Uncoupling protein 1 Uncoupling Protein 1 - deficiency Uncoupling Protein 1 - metabolism Up-Regulation |
| title | UCP1 regulates ALDH-positive breast cancer stem cells through releasing the suppression of Snail on FBP1 |
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