High‐mobility group protein B1: A predictive biomarker for hepatic encephalopathy after transjugular intrahepatic portosystemic shunt
Background The aim of the present study was to investigate whether portal level of high‐mobility group protein B1 (HMGB1) is associated with hepatic encephalopathy (HE) after transjugular intrahepatic portosystemic shunt (TIPS). Methods We enrolled 127 consecutive patients who underwent TIPS and col...
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| Veröffentlicht in: | Journal of hepato-biliary-pancreatic sciences 2020-08, Vol.27 (8), p.522-530 |
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| creator | Chen, Quan Zhang, Yu Yue, Zhen‐Dong Zhao, Hong‐Wei Wang, Lei Fan, Zhen‐Hua Liu, Fu‐Quan |
| description | Background
The aim of the present study was to investigate whether portal level of high‐mobility group protein B1 (HMGB1) is associated with hepatic encephalopathy (HE) after transjugular intrahepatic portosystemic shunt (TIPS).
Methods
We enrolled 127 consecutive patients who underwent TIPS and collected portal and peripheral blood samples in our department from December 2017 to May 2019. HMGB1 levels were determined using enzyme‐linked immunosorbent assay kits. HMGB1 and other HE related parameters were estimated by competing risk analysis, receiver operating characteristic (ROC) analysis and Kaplan–Meier analysis.
Results
Patients with HE after TIPS were older (P = .019) and had higher portal HMGB1 level (P = .038) than those without. Univariate competing risk analysis: age (sHR 1.025, P = .026), hepatorenal syndrome (sHR 3.149, P = .010), model for end‐of‐stage liver disease (MELD) score (sHR 1.055, P = .024), prior HE (sHR 4.029, P = .0005), portal HMGB1 before TIPS (sHR 1.177, P = .001) reached statistical significance. Multivariate analysis: age (sHR 1.025, P = .037), MELD score (sHR 1.062, P = .011), prior HE (sHR 2.492, P = .030) and portal HMGB1 level before TIPS (sHR 1.217, P = .0002) were significantly different. ROC analyses and Kaplan–Meier curve showed portal HMGB1 level changes before and after TIPS (ΔHMGB1) had good predictive value in the cut‐off 0.012 ng/mL (AUC = 0.748, P < .001, Sensitivity = 0.743, Specificity = 0.655).
Conclusions
Portal HMGB1 may be a therapeutic target for post‐TIPS HE.
Highlight
Chen and colleagues investigated the correlation between hepatic encephalopathy after transjugular intrahepatic portosystemic shunt (TIPS) and portal and peripheral levels of high‐mobility group protein B1 (HMGB1). HMGB1 levels were significantly higher in patients with post‐TIPS hepatic encephalopathy. A high level of portal HMGB1 posed a risk in post‐TIPS hepatic encephalopathy. |
| doi_str_mv | 10.1002/jhbp.770 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_2407581200</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2407581200</sourcerecordid><originalsourceid>FETCH-LOGICAL-c3730-24475322d8a49cbaeecbc73bd93b8f2b056bb5a10b855666d5c172d7c256ac3d3</originalsourceid><addsrcrecordid>eNp1kctq3DAUhkVJaMIk0CcogmyycaqLZdndJaHtNASSRbs2knw81tS2XElu8a67bvuMeZJoyA0K0Ub64eND5_wIvaPkjBLCPmw7PZ1JSd6gQ1oWZVZUJdt7fsv8AB2HsCXpcMorTt6iA87ygou8OkR_13bT3f35NzhtexsXvPFunvDkXQQ74gv6EZ-nBI010f4CrK0blP8BHrfO4w4mFa3BMBqYOtW7FLsFqzYmIHo1hu28mXvlsR1TfMIn56MLS4gwpBS6eYxHaL9VfYDjx3uFvn_-9O1ynV3ffPl6eX6dGS45yVieS8EZa0qVV0YrAKON5LqpuC5bpokotBaKEl0KURRFIwyVrJGGiUIZ3vAVOn3wpgl_zhBiPdhgoO_VCG4ONcuJFCVlaVkrdPIfunWzH9PvEsUFF6Tk-YvQeBeCh7aevE0rWmpK6l0_9a6fOvWT0PePwlkP0DyDT20kIHsAftselldF9dX64nYnvAc_4Z0-</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2435350834</pqid></control><display><type>article</type><title>High‐mobility group protein B1: A predictive biomarker for hepatic encephalopathy after transjugular intrahepatic portosystemic shunt</title><source>Wiley Online Library - AutoHoldings Journals</source><creator>Chen, Quan ; Zhang, Yu ; Yue, Zhen‐Dong ; Zhao, Hong‐Wei ; Wang, Lei ; Fan, Zhen‐Hua ; Liu, Fu‐Quan</creator><creatorcontrib>Chen, Quan ; Zhang, Yu ; Yue, Zhen‐Dong ; Zhao, Hong‐Wei ; Wang, Lei ; Fan, Zhen‐Hua ; Liu, Fu‐Quan</creatorcontrib><description>Background
The aim of the present study was to investigate whether portal level of high‐mobility group protein B1 (HMGB1) is associated with hepatic encephalopathy (HE) after transjugular intrahepatic portosystemic shunt (TIPS).
Methods
We enrolled 127 consecutive patients who underwent TIPS and collected portal and peripheral blood samples in our department from December 2017 to May 2019. HMGB1 levels were determined using enzyme‐linked immunosorbent assay kits. HMGB1 and other HE related parameters were estimated by competing risk analysis, receiver operating characteristic (ROC) analysis and Kaplan–Meier analysis.
Results
Patients with HE after TIPS were older (P = .019) and had higher portal HMGB1 level (P = .038) than those without. Univariate competing risk analysis: age (sHR 1.025, P = .026), hepatorenal syndrome (sHR 3.149, P = .010), model for end‐of‐stage liver disease (MELD) score (sHR 1.055, P = .024), prior HE (sHR 4.029, P = .0005), portal HMGB1 before TIPS (sHR 1.177, P = .001) reached statistical significance. Multivariate analysis: age (sHR 1.025, P = .037), MELD score (sHR 1.062, P = .011), prior HE (sHR 2.492, P = .030) and portal HMGB1 level before TIPS (sHR 1.217, P = .0002) were significantly different. ROC analyses and Kaplan–Meier curve showed portal HMGB1 level changes before and after TIPS (ΔHMGB1) had good predictive value in the cut‐off 0.012 ng/mL (AUC = 0.748, P < .001, Sensitivity = 0.743, Specificity = 0.655).
Conclusions
Portal HMGB1 may be a therapeutic target for post‐TIPS HE.
Highlight
Chen and colleagues investigated the correlation between hepatic encephalopathy after transjugular intrahepatic portosystemic shunt (TIPS) and portal and peripheral levels of high‐mobility group protein B1 (HMGB1). HMGB1 levels were significantly higher in patients with post‐TIPS hepatic encephalopathy. A high level of portal HMGB1 posed a risk in post‐TIPS hepatic encephalopathy.</description><identifier>ISSN: 1868-6974</identifier><identifier>EISSN: 1868-6982</identifier><identifier>DOI: 10.1002/jhbp.770</identifier><identifier>PMID: 32463549</identifier><language>eng</language><publisher>Japan: Wiley Subscription Services, Inc</publisher><subject>Biomarkers ; hepatic encephalopathy ; high‐mobility group protein B1 ; Medical procedures ; predictor ; Proteins ; risk factor ; Risk factors ; transjugular intrahepatic portosystemic shunt</subject><ispartof>Journal of hepato-biliary-pancreatic sciences, 2020-08, Vol.27 (8), p.522-530</ispartof><rights>2020 Japanese Society of Hepato‐Biliary‐Pancreatic Surgery</rights><rights>This article is protected by copyright. All rights reserved.</rights><rights>Copyright © 2020 Japanese Society of Hepato‐Biliary‐Pancreatic Surgery</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3730-24475322d8a49cbaeecbc73bd93b8f2b056bb5a10b855666d5c172d7c256ac3d3</citedby><cites>FETCH-LOGICAL-c3730-24475322d8a49cbaeecbc73bd93b8f2b056bb5a10b855666d5c172d7c256ac3d3</cites><orcidid>0000-0003-1512-9360</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fjhbp.770$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fjhbp.770$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,780,784,1417,27924,27925,45574,45575</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/32463549$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Chen, Quan</creatorcontrib><creatorcontrib>Zhang, Yu</creatorcontrib><creatorcontrib>Yue, Zhen‐Dong</creatorcontrib><creatorcontrib>Zhao, Hong‐Wei</creatorcontrib><creatorcontrib>Wang, Lei</creatorcontrib><creatorcontrib>Fan, Zhen‐Hua</creatorcontrib><creatorcontrib>Liu, Fu‐Quan</creatorcontrib><title>High‐mobility group protein B1: A predictive biomarker for hepatic encephalopathy after transjugular intrahepatic portosystemic shunt</title><title>Journal of hepato-biliary-pancreatic sciences</title><addtitle>J Hepatobiliary Pancreat Sci</addtitle><description>Background
The aim of the present study was to investigate whether portal level of high‐mobility group protein B1 (HMGB1) is associated with hepatic encephalopathy (HE) after transjugular intrahepatic portosystemic shunt (TIPS).
Methods
We enrolled 127 consecutive patients who underwent TIPS and collected portal and peripheral blood samples in our department from December 2017 to May 2019. HMGB1 levels were determined using enzyme‐linked immunosorbent assay kits. HMGB1 and other HE related parameters were estimated by competing risk analysis, receiver operating characteristic (ROC) analysis and Kaplan–Meier analysis.
Results
Patients with HE after TIPS were older (P = .019) and had higher portal HMGB1 level (P = .038) than those without. Univariate competing risk analysis: age (sHR 1.025, P = .026), hepatorenal syndrome (sHR 3.149, P = .010), model for end‐of‐stage liver disease (MELD) score (sHR 1.055, P = .024), prior HE (sHR 4.029, P = .0005), portal HMGB1 before TIPS (sHR 1.177, P = .001) reached statistical significance. Multivariate analysis: age (sHR 1.025, P = .037), MELD score (sHR 1.062, P = .011), prior HE (sHR 2.492, P = .030) and portal HMGB1 level before TIPS (sHR 1.217, P = .0002) were significantly different. ROC analyses and Kaplan–Meier curve showed portal HMGB1 level changes before and after TIPS (ΔHMGB1) had good predictive value in the cut‐off 0.012 ng/mL (AUC = 0.748, P < .001, Sensitivity = 0.743, Specificity = 0.655).
Conclusions
Portal HMGB1 may be a therapeutic target for post‐TIPS HE.
Highlight
Chen and colleagues investigated the correlation between hepatic encephalopathy after transjugular intrahepatic portosystemic shunt (TIPS) and portal and peripheral levels of high‐mobility group protein B1 (HMGB1). HMGB1 levels were significantly higher in patients with post‐TIPS hepatic encephalopathy. A high level of portal HMGB1 posed a risk in post‐TIPS hepatic encephalopathy.</description><subject>Biomarkers</subject><subject>hepatic encephalopathy</subject><subject>high‐mobility group protein B1</subject><subject>Medical procedures</subject><subject>predictor</subject><subject>Proteins</subject><subject>risk factor</subject><subject>Risk factors</subject><subject>transjugular intrahepatic portosystemic shunt</subject><issn>1868-6974</issn><issn>1868-6982</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><recordid>eNp1kctq3DAUhkVJaMIk0CcogmyycaqLZdndJaHtNASSRbs2knw81tS2XElu8a67bvuMeZJoyA0K0Ub64eND5_wIvaPkjBLCPmw7PZ1JSd6gQ1oWZVZUJdt7fsv8AB2HsCXpcMorTt6iA87ygou8OkR_13bT3f35NzhtexsXvPFunvDkXQQ74gv6EZ-nBI010f4CrK0blP8BHrfO4w4mFa3BMBqYOtW7FLsFqzYmIHo1hu28mXvlsR1TfMIn56MLS4gwpBS6eYxHaL9VfYDjx3uFvn_-9O1ynV3ffPl6eX6dGS45yVieS8EZa0qVV0YrAKON5LqpuC5bpokotBaKEl0KURRFIwyVrJGGiUIZ3vAVOn3wpgl_zhBiPdhgoO_VCG4ONcuJFCVlaVkrdPIfunWzH9PvEsUFF6Tk-YvQeBeCh7aevE0rWmpK6l0_9a6fOvWT0PePwlkP0DyDT20kIHsAftselldF9dX64nYnvAc_4Z0-</recordid><startdate>202008</startdate><enddate>202008</enddate><creator>Chen, Quan</creator><creator>Zhang, Yu</creator><creator>Yue, Zhen‐Dong</creator><creator>Zhao, Hong‐Wei</creator><creator>Wang, Lei</creator><creator>Fan, Zhen‐Hua</creator><creator>Liu, Fu‐Quan</creator><general>Wiley Subscription Services, Inc</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>K9.</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0003-1512-9360</orcidid></search><sort><creationdate>202008</creationdate><title>High‐mobility group protein B1: A predictive biomarker for hepatic encephalopathy after transjugular intrahepatic portosystemic shunt</title><author>Chen, Quan ; Zhang, Yu ; Yue, Zhen‐Dong ; Zhao, Hong‐Wei ; Wang, Lei ; Fan, Zhen‐Hua ; Liu, Fu‐Quan</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3730-24475322d8a49cbaeecbc73bd93b8f2b056bb5a10b855666d5c172d7c256ac3d3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><topic>Biomarkers</topic><topic>hepatic encephalopathy</topic><topic>high‐mobility group protein B1</topic><topic>Medical procedures</topic><topic>predictor</topic><topic>Proteins</topic><topic>risk factor</topic><topic>Risk factors</topic><topic>transjugular intrahepatic portosystemic shunt</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Chen, Quan</creatorcontrib><creatorcontrib>Zhang, Yu</creatorcontrib><creatorcontrib>Yue, Zhen‐Dong</creatorcontrib><creatorcontrib>Zhao, Hong‐Wei</creatorcontrib><creatorcontrib>Wang, Lei</creatorcontrib><creatorcontrib>Fan, Zhen‐Hua</creatorcontrib><creatorcontrib>Liu, Fu‐Quan</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of hepato-biliary-pancreatic sciences</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Chen, Quan</au><au>Zhang, Yu</au><au>Yue, Zhen‐Dong</au><au>Zhao, Hong‐Wei</au><au>Wang, Lei</au><au>Fan, Zhen‐Hua</au><au>Liu, Fu‐Quan</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>High‐mobility group protein B1: A predictive biomarker for hepatic encephalopathy after transjugular intrahepatic portosystemic shunt</atitle><jtitle>Journal of hepato-biliary-pancreatic sciences</jtitle><addtitle>J Hepatobiliary Pancreat Sci</addtitle><date>2020-08</date><risdate>2020</risdate><volume>27</volume><issue>8</issue><spage>522</spage><epage>530</epage><pages>522-530</pages><issn>1868-6974</issn><eissn>1868-6982</eissn><abstract>Background
The aim of the present study was to investigate whether portal level of high‐mobility group protein B1 (HMGB1) is associated with hepatic encephalopathy (HE) after transjugular intrahepatic portosystemic shunt (TIPS).
Methods
We enrolled 127 consecutive patients who underwent TIPS and collected portal and peripheral blood samples in our department from December 2017 to May 2019. HMGB1 levels were determined using enzyme‐linked immunosorbent assay kits. HMGB1 and other HE related parameters were estimated by competing risk analysis, receiver operating characteristic (ROC) analysis and Kaplan–Meier analysis.
Results
Patients with HE after TIPS were older (P = .019) and had higher portal HMGB1 level (P = .038) than those without. Univariate competing risk analysis: age (sHR 1.025, P = .026), hepatorenal syndrome (sHR 3.149, P = .010), model for end‐of‐stage liver disease (MELD) score (sHR 1.055, P = .024), prior HE (sHR 4.029, P = .0005), portal HMGB1 before TIPS (sHR 1.177, P = .001) reached statistical significance. Multivariate analysis: age (sHR 1.025, P = .037), MELD score (sHR 1.062, P = .011), prior HE (sHR 2.492, P = .030) and portal HMGB1 level before TIPS (sHR 1.217, P = .0002) were significantly different. ROC analyses and Kaplan–Meier curve showed portal HMGB1 level changes before and after TIPS (ΔHMGB1) had good predictive value in the cut‐off 0.012 ng/mL (AUC = 0.748, P < .001, Sensitivity = 0.743, Specificity = 0.655).
Conclusions
Portal HMGB1 may be a therapeutic target for post‐TIPS HE.
Highlight
Chen and colleagues investigated the correlation between hepatic encephalopathy after transjugular intrahepatic portosystemic shunt (TIPS) and portal and peripheral levels of high‐mobility group protein B1 (HMGB1). HMGB1 levels were significantly higher in patients with post‐TIPS hepatic encephalopathy. A high level of portal HMGB1 posed a risk in post‐TIPS hepatic encephalopathy.</abstract><cop>Japan</cop><pub>Wiley Subscription Services, Inc</pub><pmid>32463549</pmid><doi>10.1002/jhbp.770</doi><tpages>9</tpages><orcidid>https://orcid.org/0000-0003-1512-9360</orcidid></addata></record> |
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| identifier | ISSN: 1868-6974 |
| ispartof | Journal of hepato-biliary-pancreatic sciences, 2020-08, Vol.27 (8), p.522-530 |
| issn | 1868-6974 1868-6982 |
| language | eng |
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| source | Wiley Online Library - AutoHoldings Journals |
| subjects | Biomarkers hepatic encephalopathy high‐mobility group protein B1 Medical procedures predictor Proteins risk factor Risk factors transjugular intrahepatic portosystemic shunt |
| title | High‐mobility group protein B1: A predictive biomarker for hepatic encephalopathy after transjugular intrahepatic portosystemic shunt |
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