The ABC transporter G subfamily in Arabidopsis thaliana
Abstract ABC transporters are ubiquitously present in all kingdoms and mediate the transport of a large spectrum of structurally different compounds. Plants possess high numbers of ABC transporters in relation to other eukaryotes; the ABCG subfamily in particular is extensive. Earlier studies demons...
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Veröffentlicht in: | Journal of experimental botany 2021-01, Vol.72 (1), p.92-106 |
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description | Abstract
ABC transporters are ubiquitously present in all kingdoms and mediate the transport of a large spectrum of structurally different compounds. Plants possess high numbers of ABC transporters in relation to other eukaryotes; the ABCG subfamily in particular is extensive. Earlier studies demonstrated that ABCG transporters are involved in important processes influencing plant fitness. This review summarizes the functions of ABCG transporters present in the model plant Arabidopsis thaliana. These transporters take part in diverse processes such as pathogen response, diffusion barrier formation, or phytohormone transport. Studies involving knockout mutations reported pleiotropic phenotypes of the mutants. In some cases, different physiological roles were assigned to the same protein. The actual transported substrate(s), however, still remain to be determined for the majority of ABCG transporters. Additionally, the proposed substrate spectrum of different ABCG proteins is not always reflected by sequence identities between ABCG members. Applying only reverse genetics is thereby insufficient to clearly identify the substrate(s). We therefore stress the importance of in vitro studies in addition to in vivo studies in order to (i) clarify the substrate identity; (ii) determine the transport characteristics including directionality; and (iii) identify dimerization partners of the half-size proteins, which might in turn affect substrate specificity. |
doi_str_mv | 10.1093/jxb/eraa260 |
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ABC transporters are ubiquitously present in all kingdoms and mediate the transport of a large spectrum of structurally different compounds. Plants possess high numbers of ABC transporters in relation to other eukaryotes; the ABCG subfamily in particular is extensive. Earlier studies demonstrated that ABCG transporters are involved in important processes influencing plant fitness. This review summarizes the functions of ABCG transporters present in the model plant Arabidopsis thaliana. These transporters take part in diverse processes such as pathogen response, diffusion barrier formation, or phytohormone transport. Studies involving knockout mutations reported pleiotropic phenotypes of the mutants. In some cases, different physiological roles were assigned to the same protein. The actual transported substrate(s), however, still remain to be determined for the majority of ABCG transporters. Additionally, the proposed substrate spectrum of different ABCG proteins is not always reflected by sequence identities between ABCG members. Applying only reverse genetics is thereby insufficient to clearly identify the substrate(s). We therefore stress the importance of in vitro studies in addition to in vivo studies in order to (i) clarify the substrate identity; (ii) determine the transport characteristics including directionality; and (iii) identify dimerization partners of the half-size proteins, which might in turn affect substrate specificity.</description><identifier>ISSN: 0022-0957</identifier><identifier>EISSN: 1460-2431</identifier><identifier>DOI: 10.1093/jxb/eraa260</identifier><identifier>PMID: 32459300</identifier><language>eng</language><publisher>UK: Oxford University Press</publisher><subject>Arabidopsis - genetics ; Arabidopsis - metabolism ; Arabidopsis Proteins - genetics ; Arabidopsis Proteins - metabolism ; ATP Binding Cassette Transporter, Subfamily G ; ATP-Binding Cassette Transporters - genetics ; Life Sciences & Biomedicine ; Plant Growth Regulators ; Plant Sciences ; Science & Technology</subject><ispartof>Journal of experimental botany, 2021-01, Vol.72 (1), p.92-106</ispartof><rights>The Author(s) 2020. Published by Oxford University Press on behalf of the Society for Experimental Biology. All rights reserved. For permissions, please email: journals.permissions@oup.com 2020</rights><rights>The Author(s) 2020. Published by Oxford University Press on behalf of the Society for Experimental Biology. All rights reserved. For permissions, please email: journals.permissions@oup.com.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>true</woscitedreferencessubscribed><woscitedreferencescount>48</woscitedreferencescount><woscitedreferencesoriginalsourcerecordid>wos000613921000007</woscitedreferencesoriginalsourcerecordid><citedby>FETCH-LOGICAL-c386t-a5f1636be2fc49203f294963617fe94310c3ac7a5e718a763b48ea53eef95ac3</citedby><cites>FETCH-LOGICAL-c386t-a5f1636be2fc49203f294963617fe94310c3ac7a5e718a763b48ea53eef95ac3</cites><orcidid>0000-0002-1167-9819</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>315,781,785,1585,27928,27929</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/32459300$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><contributor>Weber, Andreas</contributor><creatorcontrib>Gräfe, Katharina</creatorcontrib><creatorcontrib>Schmitt, Lutz</creatorcontrib><title>The ABC transporter G subfamily in Arabidopsis thaliana</title><title>Journal of experimental botany</title><addtitle>J EXP BOT</addtitle><addtitle>J Exp Bot</addtitle><description>Abstract
ABC transporters are ubiquitously present in all kingdoms and mediate the transport of a large spectrum of structurally different compounds. Plants possess high numbers of ABC transporters in relation to other eukaryotes; the ABCG subfamily in particular is extensive. Earlier studies demonstrated that ABCG transporters are involved in important processes influencing plant fitness. This review summarizes the functions of ABCG transporters present in the model plant Arabidopsis thaliana. These transporters take part in diverse processes such as pathogen response, diffusion barrier formation, or phytohormone transport. Studies involving knockout mutations reported pleiotropic phenotypes of the mutants. In some cases, different physiological roles were assigned to the same protein. The actual transported substrate(s), however, still remain to be determined for the majority of ABCG transporters. Additionally, the proposed substrate spectrum of different ABCG proteins is not always reflected by sequence identities between ABCG members. Applying only reverse genetics is thereby insufficient to clearly identify the substrate(s). We therefore stress the importance of in vitro studies in addition to in vivo studies in order to (i) clarify the substrate identity; (ii) determine the transport characteristics including directionality; and (iii) identify dimerization partners of the half-size proteins, which might in turn affect substrate specificity.</description><subject>Arabidopsis - genetics</subject><subject>Arabidopsis - metabolism</subject><subject>Arabidopsis Proteins - genetics</subject><subject>Arabidopsis Proteins - metabolism</subject><subject>ATP Binding Cassette Transporter, Subfamily G</subject><subject>ATP-Binding Cassette Transporters - genetics</subject><subject>Life Sciences & Biomedicine</subject><subject>Plant Growth Regulators</subject><subject>Plant Sciences</subject><subject>Science & Technology</subject><issn>0022-0957</issn><issn>1460-2431</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><sourceid>HGBXW</sourceid><sourceid>EIF</sourceid><recordid>eNqNkE1LxDAQhoMoun6cvEtPIkh1kjTN5rgWv0DwsvcyjROMdJuatKj_3squehPnMjA878vwMHbM4YKDkZcv780lRURRwhab8aKEXBSSb7MZgBA5GKX32H5KLwCgQKldtidFoYwEmDG9fKZscVVlQ8Qu9SEOFLPbLI2Nw5VvPzLfZYuIjX8KffIpG56x9djhIdtx2CY62uwDtry5XlZ3-cPj7X21eMitnJdDjsrxUpYNCWcLI0A6YQozXbh2ZKYvwUq0GhVpPkddyqaYEypJ5IxCKw_Y2bq2j-F1pDTUK58stS12FMZUiwK05KXWZkLP16iNIaVIru6jX2H8qDnUX6LqSVS9ETXRJ5visVnR0w_7bea37o2a4JL11Fn6wSaVJZdGcPgaPdHz_9OVH3DwoavC2A1T9HQdDWP_58ufIJOQ3w</recordid><startdate>20210120</startdate><enddate>20210120</enddate><creator>Gräfe, Katharina</creator><creator>Schmitt, Lutz</creator><general>Oxford University Press</general><general>Oxford Univ Press</general><scope>BLEPL</scope><scope>DTL</scope><scope>HGBXW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0002-1167-9819</orcidid></search><sort><creationdate>20210120</creationdate><title>The ABC transporter G subfamily in Arabidopsis thaliana</title><author>Gräfe, Katharina ; Schmitt, Lutz</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c386t-a5f1636be2fc49203f294963617fe94310c3ac7a5e718a763b48ea53eef95ac3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>Arabidopsis - genetics</topic><topic>Arabidopsis - metabolism</topic><topic>Arabidopsis Proteins - genetics</topic><topic>Arabidopsis Proteins - metabolism</topic><topic>ATP Binding Cassette Transporter, Subfamily G</topic><topic>ATP-Binding Cassette Transporters - genetics</topic><topic>Life Sciences & Biomedicine</topic><topic>Plant Growth Regulators</topic><topic>Plant Sciences</topic><topic>Science & Technology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Gräfe, Katharina</creatorcontrib><creatorcontrib>Schmitt, Lutz</creatorcontrib><collection>Web of Science Core Collection</collection><collection>Science Citation Index Expanded</collection><collection>Web of Science - Science Citation Index Expanded - 2021</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of experimental botany</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Gräfe, Katharina</au><au>Schmitt, Lutz</au><au>Weber, Andreas</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The ABC transporter G subfamily in Arabidopsis thaliana</atitle><jtitle>Journal of experimental botany</jtitle><stitle>J EXP BOT</stitle><addtitle>J Exp Bot</addtitle><date>2021-01-20</date><risdate>2021</risdate><volume>72</volume><issue>1</issue><spage>92</spage><epage>106</epage><pages>92-106</pages><issn>0022-0957</issn><eissn>1460-2431</eissn><abstract>Abstract
ABC transporters are ubiquitously present in all kingdoms and mediate the transport of a large spectrum of structurally different compounds. Plants possess high numbers of ABC transporters in relation to other eukaryotes; the ABCG subfamily in particular is extensive. Earlier studies demonstrated that ABCG transporters are involved in important processes influencing plant fitness. This review summarizes the functions of ABCG transporters present in the model plant Arabidopsis thaliana. These transporters take part in diverse processes such as pathogen response, diffusion barrier formation, or phytohormone transport. Studies involving knockout mutations reported pleiotropic phenotypes of the mutants. In some cases, different physiological roles were assigned to the same protein. The actual transported substrate(s), however, still remain to be determined for the majority of ABCG transporters. Additionally, the proposed substrate spectrum of different ABCG proteins is not always reflected by sequence identities between ABCG members. Applying only reverse genetics is thereby insufficient to clearly identify the substrate(s). We therefore stress the importance of in vitro studies in addition to in vivo studies in order to (i) clarify the substrate identity; (ii) determine the transport characteristics including directionality; and (iii) identify dimerization partners of the half-size proteins, which might in turn affect substrate specificity.</abstract><cop>UK</cop><pub>Oxford University Press</pub><pmid>32459300</pmid><doi>10.1093/jxb/eraa260</doi><tpages>15</tpages><orcidid>https://orcid.org/0000-0002-1167-9819</orcidid></addata></record> |
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subjects | Arabidopsis - genetics Arabidopsis - metabolism Arabidopsis Proteins - genetics Arabidopsis Proteins - metabolism ATP Binding Cassette Transporter, Subfamily G ATP-Binding Cassette Transporters - genetics Life Sciences & Biomedicine Plant Growth Regulators Plant Sciences Science & Technology |
title | The ABC transporter G subfamily in Arabidopsis thaliana |
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