Molecular Identification of Candida Species in the Oral Microbiota of Individuals with Down Syndrome: A Case–Control Study
Candida species are common in the human oral microbiota and may cause oral candidiasis (OC) when the microbiota equilibrium is disturbed. Immunosuppressed individuals are susceptible to oral infections as individuals with Down syndrome (IDS) due to particularities of their mouth morphoanatomy, saliv...
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| Veröffentlicht in: | Mycopathologia (1975) 2020-06, Vol.185 (3), p.537-543 |
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| creator | Maranhão, Fernanda Cristina de Albuquerque Mendonça, Nayara Maciel Teixeira, Thamires Costa Lages, Gilvonete Alves da Costa Sobrinha de Melo, Jacqueline Araújo Porciuncula, Carlos Guilherme Gaelzer da Silva Filho, Eurípedes Alves Silva, Denise Maria Wanderlei |
| description | Candida
species are common in the human oral microbiota and may cause oral candidiasis (OC) when the microbiota equilibrium is disturbed. Immunosuppressed individuals are susceptible to oral infections as individuals with Down syndrome (IDS) due to particularities of their mouth morphoanatomy, saliva and comorbidities. This study aimed to analyze the molecular epidemiology of
Candida
spp. from the oral cavity of IDS and their relatives. A case–control study with 80 IDS and 80 non-syndromic (non-DS) was evaluated by oral swab collection for culture on Sabouraud dextrose agar, selection of yeast colonies to Gram staining and culturing on chromogenic media. DNA extraction was performed with the phenol/chloroform method for screening of 6
Candida
species medically important in PCR, applying SPSS for statistics. We confirmed four species in 46 IDS without use of antimicrobials (57.54%), with a high prevalence of
C. albicans/Ca
(93.48%/43) and 3
C. glabrata/Cg
(6.52%), being 25 of these IDS (31.25%) colonized by species other than
C. albicans: Ca
+
Cg
(16),
Ca
+
C. tropicalis/Ct
(7) and
Ca
+
C. krusei/Ck
(2). Only 10 non-DS were colonized by one species (11.25%): 6
C. albicans,
2
C. glabrata
, 1
C. tropicalis
and 1
C. krusei
. Previous OC was reported by 39 IDS (48.75%), being 33 positives for
Candida
spp. (84.61%) and 17 with active OC (21.25%). Five non-DS reported OC previously and had no active lesions. Behavioral changes and buccal health programs directed to IDS may help prevent OC and its recurrence, providing information on oral hygiene for self-care. |
| doi_str_mv | 10.1007/s11046-020-00457-6 |
| format | Article |
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species are common in the human oral microbiota and may cause oral candidiasis (OC) when the microbiota equilibrium is disturbed. Immunosuppressed individuals are susceptible to oral infections as individuals with Down syndrome (IDS) due to particularities of their mouth morphoanatomy, saliva and comorbidities. This study aimed to analyze the molecular epidemiology of
Candida
spp. from the oral cavity of IDS and their relatives. A case–control study with 80 IDS and 80 non-syndromic (non-DS) was evaluated by oral swab collection for culture on Sabouraud dextrose agar, selection of yeast colonies to Gram staining and culturing on chromogenic media. DNA extraction was performed with the phenol/chloroform method for screening of 6
Candida
species medically important in PCR, applying SPSS for statistics. We confirmed four species in 46 IDS without use of antimicrobials (57.54%), with a high prevalence of
C. albicans/Ca
(93.48%/43) and 3
C. glabrata/Cg
(6.52%), being 25 of these IDS (31.25%) colonized by species other than
C. albicans: Ca
+
Cg
(16),
Ca
+
C. tropicalis/Ct
(7) and
Ca
+
C. krusei/Ck
(2). Only 10 non-DS were colonized by one species (11.25%): 6
C. albicans,
2
C. glabrata
, 1
C. tropicalis
and 1
C. krusei
. Previous OC was reported by 39 IDS (48.75%), being 33 positives for
Candida
spp. (84.61%) and 17 with active OC (21.25%). Five non-DS reported OC previously and had no active lesions. Behavioral changes and buccal health programs directed to IDS may help prevent OC and its recurrence, providing information on oral hygiene for self-care.</description><identifier>ISSN: 0301-486X</identifier><identifier>EISSN: 1573-0832</identifier><identifier>DOI: 10.1007/s11046-020-00457-6</identifier><identifier>PMID: 32458314</identifier><language>eng</language><publisher>Dordrecht: Springer Netherlands</publisher><subject>Analysis ; Anti-infective agents ; Antimicrobial agents ; Biomedical and Life Sciences ; Candida ; Candida krusei ; Candidiasis ; Chloroform ; Culture media ; Dextrose ; Disease susceptibility ; Down syndrome ; Down's syndrome ; Epidemiology ; Eukaryotic Microbiology ; Health aspects ; Life Sciences ; Medical Microbiology ; Medical research ; Medicine, Experimental ; Microbial Ecology ; Microbiology ; Microbiota ; Microbiota (Symbiotic organisms) ; Microorganisms ; Mycoses ; Oral cavity ; Oral hygiene ; Original Article ; Phenols ; Plant Sciences ; Prenatal diagnosis ; Saliva ; Species ; Toiletries industry</subject><ispartof>Mycopathologia (1975), 2020-06, Vol.185 (3), p.537-543</ispartof><rights>Springer Nature B.V. 2020</rights><rights>COPYRIGHT 2020 Springer</rights><rights>Springer Nature B.V. 2020.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c476t-a7318ae973acce5aeb6060c6b396f48070392af4ed3ed375290ec2add7bc6cf43</citedby><cites>FETCH-LOGICAL-c476t-a7318ae973acce5aeb6060c6b396f48070392af4ed3ed375290ec2add7bc6cf43</cites><orcidid>0000-0002-4255-6563 ; 0000-0001-9641-4264</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s11046-020-00457-6$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s11046-020-00457-6$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,780,784,27924,27925,41488,42557,51319</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/32458314$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Maranhão, Fernanda Cristina de Albuquerque</creatorcontrib><creatorcontrib>Mendonça, Nayara Maciel</creatorcontrib><creatorcontrib>Teixeira, Thamires Costa</creatorcontrib><creatorcontrib>Lages, Gilvonete Alves da Costa Sobrinha</creatorcontrib><creatorcontrib>de Melo, Jacqueline Araújo</creatorcontrib><creatorcontrib>Porciuncula, Carlos Guilherme Gaelzer</creatorcontrib><creatorcontrib>da Silva Filho, Eurípedes Alves</creatorcontrib><creatorcontrib>Silva, Denise Maria Wanderlei</creatorcontrib><title>Molecular Identification of Candida Species in the Oral Microbiota of Individuals with Down Syndrome: A Case–Control Study</title><title>Mycopathologia (1975)</title><addtitle>Mycopathologia</addtitle><addtitle>Mycopathologia</addtitle><description>Candida
species are common in the human oral microbiota and may cause oral candidiasis (OC) when the microbiota equilibrium is disturbed. Immunosuppressed individuals are susceptible to oral infections as individuals with Down syndrome (IDS) due to particularities of their mouth morphoanatomy, saliva and comorbidities. This study aimed to analyze the molecular epidemiology of
Candida
spp. from the oral cavity of IDS and their relatives. A case–control study with 80 IDS and 80 non-syndromic (non-DS) was evaluated by oral swab collection for culture on Sabouraud dextrose agar, selection of yeast colonies to Gram staining and culturing on chromogenic media. DNA extraction was performed with the phenol/chloroform method for screening of 6
Candida
species medically important in PCR, applying SPSS for statistics. We confirmed four species in 46 IDS without use of antimicrobials (57.54%), with a high prevalence of
C. albicans/Ca
(93.48%/43) and 3
C. glabrata/Cg
(6.52%), being 25 of these IDS (31.25%) colonized by species other than
C. albicans: Ca
+
Cg
(16),
Ca
+
C. tropicalis/Ct
(7) and
Ca
+
C. krusei/Ck
(2). Only 10 non-DS were colonized by one species (11.25%): 6
C. albicans,
2
C. glabrata
, 1
C. tropicalis
and 1
C. krusei
. Previous OC was reported by 39 IDS (48.75%), being 33 positives for
Candida
spp. (84.61%) and 17 with active OC (21.25%). Five non-DS reported OC previously and had no active lesions. Behavioral changes and buccal health programs directed to IDS may help prevent OC and its recurrence, providing information on oral hygiene for self-care.</description><subject>Analysis</subject><subject>Anti-infective agents</subject><subject>Antimicrobial agents</subject><subject>Biomedical and Life Sciences</subject><subject>Candida</subject><subject>Candida krusei</subject><subject>Candidiasis</subject><subject>Chloroform</subject><subject>Culture media</subject><subject>Dextrose</subject><subject>Disease susceptibility</subject><subject>Down syndrome</subject><subject>Down's syndrome</subject><subject>Epidemiology</subject><subject>Eukaryotic Microbiology</subject><subject>Health aspects</subject><subject>Life Sciences</subject><subject>Medical Microbiology</subject><subject>Medical research</subject><subject>Medicine, Experimental</subject><subject>Microbial Ecology</subject><subject>Microbiology</subject><subject>Microbiota</subject><subject>Microbiota (Symbiotic organisms)</subject><subject>Microorganisms</subject><subject>Mycoses</subject><subject>Oral cavity</subject><subject>Oral hygiene</subject><subject>Original Article</subject><subject>Phenols</subject><subject>Plant Sciences</subject><subject>Prenatal diagnosis</subject><subject>Saliva</subject><subject>Species</subject><subject>Toiletries 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Syndrome: A Case–Control Study</title><author>Maranhão, Fernanda Cristina de Albuquerque ; Mendonça, Nayara Maciel ; Teixeira, Thamires Costa ; Lages, Gilvonete Alves da Costa Sobrinha ; de Melo, Jacqueline Araújo ; Porciuncula, Carlos Guilherme Gaelzer ; da Silva Filho, Eurípedes Alves ; Silva, Denise Maria Wanderlei</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c476t-a7318ae973acce5aeb6060c6b396f48070392af4ed3ed375290ec2add7bc6cf43</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><topic>Analysis</topic><topic>Anti-infective agents</topic><topic>Antimicrobial agents</topic><topic>Biomedical and Life Sciences</topic><topic>Candida</topic><topic>Candida krusei</topic><topic>Candidiasis</topic><topic>Chloroform</topic><topic>Culture media</topic><topic>Dextrose</topic><topic>Disease susceptibility</topic><topic>Down syndrome</topic><topic>Down's syndrome</topic><topic>Epidemiology</topic><topic>Eukaryotic Microbiology</topic><topic>Health aspects</topic><topic>Life Sciences</topic><topic>Medical Microbiology</topic><topic>Medical research</topic><topic>Medicine, Experimental</topic><topic>Microbial Ecology</topic><topic>Microbiology</topic><topic>Microbiota</topic><topic>Microbiota (Symbiotic organisms)</topic><topic>Microorganisms</topic><topic>Mycoses</topic><topic>Oral cavity</topic><topic>Oral hygiene</topic><topic>Original Article</topic><topic>Phenols</topic><topic>Plant Sciences</topic><topic>Prenatal diagnosis</topic><topic>Saliva</topic><topic>Species</topic><topic>Toiletries industry</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Maranhão, Fernanda Cristina de Albuquerque</creatorcontrib><creatorcontrib>Mendonça, Nayara Maciel</creatorcontrib><creatorcontrib>Teixeira, Thamires Costa</creatorcontrib><creatorcontrib>Lages, Gilvonete Alves da Costa Sobrinha</creatorcontrib><creatorcontrib>de Melo, Jacqueline Araújo</creatorcontrib><creatorcontrib>Porciuncula, Carlos Guilherme Gaelzer</creatorcontrib><creatorcontrib>da Silva Filho, Eurípedes Alves</creatorcontrib><creatorcontrib>Silva, Denise Maria Wanderlei</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>Gale In Context: Science</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection (Proquest)</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Biology Database (Alumni Edition)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest 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Syndrome: A Case–Control Study</atitle><jtitle>Mycopathologia (1975)</jtitle><stitle>Mycopathologia</stitle><addtitle>Mycopathologia</addtitle><date>2020-06-01</date><risdate>2020</risdate><volume>185</volume><issue>3</issue><spage>537</spage><epage>543</epage><pages>537-543</pages><issn>0301-486X</issn><eissn>1573-0832</eissn><abstract>Candida
species are common in the human oral microbiota and may cause oral candidiasis (OC) when the microbiota equilibrium is disturbed. Immunosuppressed individuals are susceptible to oral infections as individuals with Down syndrome (IDS) due to particularities of their mouth morphoanatomy, saliva and comorbidities. This study aimed to analyze the molecular epidemiology of
Candida
spp. from the oral cavity of IDS and their relatives. A case–control study with 80 IDS and 80 non-syndromic (non-DS) was evaluated by oral swab collection for culture on Sabouraud dextrose agar, selection of yeast colonies to Gram staining and culturing on chromogenic media. DNA extraction was performed with the phenol/chloroform method for screening of 6
Candida
species medically important in PCR, applying SPSS for statistics. We confirmed four species in 46 IDS without use of antimicrobials (57.54%), with a high prevalence of
C. albicans/Ca
(93.48%/43) and 3
C. glabrata/Cg
(6.52%), being 25 of these IDS (31.25%) colonized by species other than
C. albicans: Ca
+
Cg
(16),
Ca
+
C. tropicalis/Ct
(7) and
Ca
+
C. krusei/Ck
(2). Only 10 non-DS were colonized by one species (11.25%): 6
C. albicans,
2
C. glabrata
, 1
C. tropicalis
and 1
C. krusei
. Previous OC was reported by 39 IDS (48.75%), being 33 positives for
Candida
spp. (84.61%) and 17 with active OC (21.25%). Five non-DS reported OC previously and had no active lesions. Behavioral changes and buccal health programs directed to IDS may help prevent OC and its recurrence, providing information on oral hygiene for self-care.</abstract><cop>Dordrecht</cop><pub>Springer Netherlands</pub><pmid>32458314</pmid><doi>10.1007/s11046-020-00457-6</doi><tpages>7</tpages><orcidid>https://orcid.org/0000-0002-4255-6563</orcidid><orcidid>https://orcid.org/0000-0001-9641-4264</orcidid></addata></record> |
| fulltext | fulltext |
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| ispartof | Mycopathologia (1975), 2020-06, Vol.185 (3), p.537-543 |
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| language | eng |
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| source | SpringerLink Journals |
| subjects | Analysis Anti-infective agents Antimicrobial agents Biomedical and Life Sciences Candida Candida krusei Candidiasis Chloroform Culture media Dextrose Disease susceptibility Down syndrome Down's syndrome Epidemiology Eukaryotic Microbiology Health aspects Life Sciences Medical Microbiology Medical research Medicine, Experimental Microbial Ecology Microbiology Microbiota Microbiota (Symbiotic organisms) Microorganisms Mycoses Oral cavity Oral hygiene Original Article Phenols Plant Sciences Prenatal diagnosis Saliva Species Toiletries industry |
| title | Molecular Identification of Candida Species in the Oral Microbiota of Individuals with Down Syndrome: A Case–Control Study |
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