Effect of small vessel disease burden and lacunes on gait/posture impairment in Parkinson’s disease
Introduction The comorbidity of cerebral small vessel disease (CSVD) may worsen gait impairment of Parkinson’s disease (PD). However, the evidence remains scarce and controversial, and the mechanism of their potential interaction remains largely unknown. The present study aimed to investigate the ov...
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| Veröffentlicht in: | Neurological sciences 2020-12, Vol.41 (12), p.3617-3624 |
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| creator | Chen, Huimin Zhang, Meimei Liu, Gengliang Wang, Xuemei Wang, Zhan Ma, Huizi Pan, Yuesong Wang, David Wang, Yilong Feng, Tao |
| description | Introduction
The comorbidity of cerebral small vessel disease (CSVD) may worsen gait impairment of Parkinson’s disease (PD). However, the evidence remains scarce and controversial, and the mechanism of their potential interaction remains largely unknown. The present study aimed to investigate the overall impact of quantity and location of CSVD on gait/posture function in PD.
Methods
This cross-sectional study included 315 consecutive eligible patients with PD from Beijing Tiantan Hospital from May 2016 to August 2018. Associations of gait/posture subscores with the burden score of CSVD and four CSVD imaging markers were assessed using multivariate linear regression models.
Results
Burden of CSVD was significantly associated with more severe gait/posture impairment in PD in the unadjusted model (
β
= 0.521,
P
= 0.011, 95% CI 0.118–0.923) and in the model adjusted for age, hypertension, ischemic stroke, low-density lipoprotein level, cholesterol level, and cognitive statues (
β
= 0.448,
P
= 0.047, 95% CI 0.006–0.891). The presence of lacunes, but not other CSVD markers, was significantly associated with higher gait/posture subscores after the adjustment (
β
= 0.492,
P
= 0.041, 95% CI 0.021–0.964), and the number of lacunes in the basal ganglia significantly correlated with the gait/posture subscores in patients with PD (
P
= 0.012, Spearman
r
= 0.161).
Conclusions
CSVD and lacunes in the basal ganglia may independently contribute to gait/posture dysfunction in PD. Promoting neurovascular health may preserve some gait/posture function of PD. |
| doi_str_mv | 10.1007/s10072-020-04452-z |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_2407313726</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2407313726</sourcerecordid><originalsourceid>FETCH-LOGICAL-c375t-f919ceba95ce03822f23ac21f7e2e211849366cedf25e3b29475a64a39cc64cf3</originalsourceid><addsrcrecordid>eNp9kc9O3DAQxi3Uin_tC3BAlnrpJcUeO3F8RCtakJDKoZwtrzNeBRJn60mQyonX6Ov1SQjsQiUOXGZGmt98M5qPsSMpvkkhzAk9RSgEiEJoXUJxv8P2ZWlFobSpP2xrWRu9xw6IboQQUku1y_YU6LIGbfcZnsWIYeRD5NT7ruN3SIQdb1pCT8iXU24wcZ8a3vkwJSQ-JL7y7XiyHmicMvK2X_s295hG3iZ-5fNtm2hI_x7-0ovMJ_Yx-o7w8zYfsuvvZ78W58Xlzx8Xi9PLIihTjkW00gZcelsGFKoGiKB8ABkNAoKUtbaqqgI2EUpUS7DalL7SXtkQKh2iOmRfN7rrPPyekEbXtxSw63zCYSIHWhgllYFqRr-8QW-GKaf5upkysgQD0s4UbKiQB6KM0a1z2_v8x0nhnt7vNia42QT3bIK7n4eOt9LTssfmdeTl6zOgNgDNrbTC_H_3O7KP1mGT2w</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2471527219</pqid></control><display><type>article</type><title>Effect of small vessel disease burden and lacunes on gait/posture impairment in Parkinson’s disease</title><source>MEDLINE</source><source>SpringerLink Journals - AutoHoldings</source><creator>Chen, Huimin ; Zhang, Meimei ; Liu, Gengliang ; Wang, Xuemei ; Wang, Zhan ; Ma, Huizi ; Pan, Yuesong ; Wang, David ; Wang, Yilong ; Feng, Tao</creator><creatorcontrib>Chen, Huimin ; Zhang, Meimei ; Liu, Gengliang ; Wang, Xuemei ; Wang, Zhan ; Ma, Huizi ; Pan, Yuesong ; Wang, David ; Wang, Yilong ; Feng, Tao</creatorcontrib><description>Introduction
The comorbidity of cerebral small vessel disease (CSVD) may worsen gait impairment of Parkinson’s disease (PD). However, the evidence remains scarce and controversial, and the mechanism of their potential interaction remains largely unknown. The present study aimed to investigate the overall impact of quantity and location of CSVD on gait/posture function in PD.
Methods
This cross-sectional study included 315 consecutive eligible patients with PD from Beijing Tiantan Hospital from May 2016 to August 2018. Associations of gait/posture subscores with the burden score of CSVD and four CSVD imaging markers were assessed using multivariate linear regression models.
Results
Burden of CSVD was significantly associated with more severe gait/posture impairment in PD in the unadjusted model (
β
= 0.521,
P
= 0.011, 95% CI 0.118–0.923) and in the model adjusted for age, hypertension, ischemic stroke, low-density lipoprotein level, cholesterol level, and cognitive statues (
β
= 0.448,
P
= 0.047, 95% CI 0.006–0.891). The presence of lacunes, but not other CSVD markers, was significantly associated with higher gait/posture subscores after the adjustment (
β
= 0.492,
P
= 0.041, 95% CI 0.021–0.964), and the number of lacunes in the basal ganglia significantly correlated with the gait/posture subscores in patients with PD (
P
= 0.012, Spearman
r
= 0.161).
Conclusions
CSVD and lacunes in the basal ganglia may independently contribute to gait/posture dysfunction in PD. Promoting neurovascular health may preserve some gait/posture function of PD.</description><identifier>ISSN: 1590-1874</identifier><identifier>EISSN: 1590-3478</identifier><identifier>DOI: 10.1007/s10072-020-04452-z</identifier><identifier>PMID: 32458249</identifier><language>eng</language><publisher>Cham: Springer International Publishing</publisher><subject>Basal ganglia ; Cerebral Small Vessel Diseases - complications ; Cerebral Small Vessel Diseases - diagnostic imaging ; Cerebral Small Vessel Diseases - epidemiology ; Cholesterol ; Cognitive ability ; Cost of Illness ; Cross-Sectional Studies ; Gait ; Humans ; Ischemia ; Magnetic Resonance Imaging ; Medicine ; Medicine & Public Health ; Movement disorders ; Neurodegenerative diseases ; Neurology ; Neuroradiology ; Neurosciences ; Neurosurgery ; Original Article ; Parkinson Disease - complications ; Parkinson Disease - epidemiology ; Parkinson's disease ; Posture ; Psychiatry ; Regression analysis ; Vascular diseases</subject><ispartof>Neurological sciences, 2020-12, Vol.41 (12), p.3617-3624</ispartof><rights>Fondazione Società Italiana di Neurologia 2020</rights><rights>Fondazione Società Italiana di Neurologia 2020.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c375t-f919ceba95ce03822f23ac21f7e2e211849366cedf25e3b29475a64a39cc64cf3</citedby><cites>FETCH-LOGICAL-c375t-f919ceba95ce03822f23ac21f7e2e211849366cedf25e3b29475a64a39cc64cf3</cites><orcidid>0000-0002-8530-4622</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s10072-020-04452-z$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s10072-020-04452-z$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,780,784,27924,27925,41488,42557,51319</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/32458249$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Chen, Huimin</creatorcontrib><creatorcontrib>Zhang, Meimei</creatorcontrib><creatorcontrib>Liu, Gengliang</creatorcontrib><creatorcontrib>Wang, Xuemei</creatorcontrib><creatorcontrib>Wang, Zhan</creatorcontrib><creatorcontrib>Ma, Huizi</creatorcontrib><creatorcontrib>Pan, Yuesong</creatorcontrib><creatorcontrib>Wang, David</creatorcontrib><creatorcontrib>Wang, Yilong</creatorcontrib><creatorcontrib>Feng, Tao</creatorcontrib><title>Effect of small vessel disease burden and lacunes on gait/posture impairment in Parkinson’s disease</title><title>Neurological sciences</title><addtitle>Neurol Sci</addtitle><addtitle>Neurol Sci</addtitle><description>Introduction
The comorbidity of cerebral small vessel disease (CSVD) may worsen gait impairment of Parkinson’s disease (PD). However, the evidence remains scarce and controversial, and the mechanism of their potential interaction remains largely unknown. The present study aimed to investigate the overall impact of quantity and location of CSVD on gait/posture function in PD.
Methods
This cross-sectional study included 315 consecutive eligible patients with PD from Beijing Tiantan Hospital from May 2016 to August 2018. Associations of gait/posture subscores with the burden score of CSVD and four CSVD imaging markers were assessed using multivariate linear regression models.
Results
Burden of CSVD was significantly associated with more severe gait/posture impairment in PD in the unadjusted model (
β
= 0.521,
P
= 0.011, 95% CI 0.118–0.923) and in the model adjusted for age, hypertension, ischemic stroke, low-density lipoprotein level, cholesterol level, and cognitive statues (
β
= 0.448,
P
= 0.047, 95% CI 0.006–0.891). The presence of lacunes, but not other CSVD markers, was significantly associated with higher gait/posture subscores after the adjustment (
β
= 0.492,
P
= 0.041, 95% CI 0.021–0.964), and the number of lacunes in the basal ganglia significantly correlated with the gait/posture subscores in patients with PD (
P
= 0.012, Spearman
r
= 0.161).
Conclusions
CSVD and lacunes in the basal ganglia may independently contribute to gait/posture dysfunction in PD. Promoting neurovascular health may preserve some gait/posture function of PD.</description><subject>Basal ganglia</subject><subject>Cerebral Small Vessel Diseases - complications</subject><subject>Cerebral Small Vessel Diseases - diagnostic imaging</subject><subject>Cerebral Small Vessel Diseases - epidemiology</subject><subject>Cholesterol</subject><subject>Cognitive ability</subject><subject>Cost of Illness</subject><subject>Cross-Sectional Studies</subject><subject>Gait</subject><subject>Humans</subject><subject>Ischemia</subject><subject>Magnetic Resonance Imaging</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Movement disorders</subject><subject>Neurodegenerative diseases</subject><subject>Neurology</subject><subject>Neuroradiology</subject><subject>Neurosciences</subject><subject>Neurosurgery</subject><subject>Original Article</subject><subject>Parkinson Disease - complications</subject><subject>Parkinson Disease - epidemiology</subject><subject>Parkinson's disease</subject><subject>Posture</subject><subject>Psychiatry</subject><subject>Regression analysis</subject><subject>Vascular diseases</subject><issn>1590-1874</issn><issn>1590-3478</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNp9kc9O3DAQxi3Uin_tC3BAlnrpJcUeO3F8RCtakJDKoZwtrzNeBRJn60mQyonX6Ov1SQjsQiUOXGZGmt98M5qPsSMpvkkhzAk9RSgEiEJoXUJxv8P2ZWlFobSpP2xrWRu9xw6IboQQUku1y_YU6LIGbfcZnsWIYeRD5NT7ruN3SIQdb1pCT8iXU24wcZ8a3vkwJSQ-JL7y7XiyHmicMvK2X_s295hG3iZ-5fNtm2hI_x7-0ovMJ_Yx-o7w8zYfsuvvZ78W58Xlzx8Xi9PLIihTjkW00gZcelsGFKoGiKB8ABkNAoKUtbaqqgI2EUpUS7DalL7SXtkQKh2iOmRfN7rrPPyekEbXtxSw63zCYSIHWhgllYFqRr-8QW-GKaf5upkysgQD0s4UbKiQB6KM0a1z2_v8x0nhnt7vNia42QT3bIK7n4eOt9LTssfmdeTl6zOgNgDNrbTC_H_3O7KP1mGT2w</recordid><startdate>20201201</startdate><enddate>20201201</enddate><creator>Chen, Huimin</creator><creator>Zhang, Meimei</creator><creator>Liu, Gengliang</creator><creator>Wang, Xuemei</creator><creator>Wang, Zhan</creator><creator>Ma, Huizi</creator><creator>Pan, Yuesong</creator><creator>Wang, David</creator><creator>Wang, Yilong</creator><creator>Feng, Tao</creator><general>Springer International Publishing</general><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7TK</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>88G</scope><scope>8AO</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>K9-</scope><scope>K9.</scope><scope>M0R</scope><scope>M0S</scope><scope>M1P</scope><scope>M2M</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>PSYQQ</scope><scope>Q9U</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0002-8530-4622</orcidid></search><sort><creationdate>20201201</creationdate><title>Effect of small vessel disease burden and lacunes on gait/posture impairment in Parkinson’s disease</title><author>Chen, Huimin ; Zhang, Meimei ; Liu, Gengliang ; Wang, Xuemei ; Wang, Zhan ; Ma, Huizi ; Pan, Yuesong ; Wang, David ; Wang, Yilong ; Feng, Tao</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c375t-f919ceba95ce03822f23ac21f7e2e211849366cedf25e3b29475a64a39cc64cf3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><topic>Basal ganglia</topic><topic>Cerebral Small Vessel Diseases - complications</topic><topic>Cerebral Small Vessel Diseases - diagnostic imaging</topic><topic>Cerebral Small Vessel Diseases - epidemiology</topic><topic>Cholesterol</topic><topic>Cognitive ability</topic><topic>Cost of Illness</topic><topic>Cross-Sectional Studies</topic><topic>Gait</topic><topic>Humans</topic><topic>Ischemia</topic><topic>Magnetic Resonance Imaging</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Movement disorders</topic><topic>Neurodegenerative diseases</topic><topic>Neurology</topic><topic>Neuroradiology</topic><topic>Neurosciences</topic><topic>Neurosurgery</topic><topic>Original Article</topic><topic>Parkinson Disease - complications</topic><topic>Parkinson Disease - epidemiology</topic><topic>Parkinson's disease</topic><topic>Posture</topic><topic>Psychiatry</topic><topic>Regression analysis</topic><topic>Vascular diseases</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Chen, Huimin</creatorcontrib><creatorcontrib>Zhang, Meimei</creatorcontrib><creatorcontrib>Liu, Gengliang</creatorcontrib><creatorcontrib>Wang, Xuemei</creatorcontrib><creatorcontrib>Wang, Zhan</creatorcontrib><creatorcontrib>Ma, Huizi</creatorcontrib><creatorcontrib>Pan, Yuesong</creatorcontrib><creatorcontrib>Wang, David</creatorcontrib><creatorcontrib>Wang, Yilong</creatorcontrib><creatorcontrib>Feng, Tao</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Neurosciences Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Psychology Database (Alumni)</collection><collection>ProQuest Pharma Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>Consumer Health Database (Alumni Edition)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Consumer Health Database</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Psychology Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>ProQuest One Psychology</collection><collection>ProQuest Central Basic</collection><collection>MEDLINE - Academic</collection><jtitle>Neurological sciences</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Chen, Huimin</au><au>Zhang, Meimei</au><au>Liu, Gengliang</au><au>Wang, Xuemei</au><au>Wang, Zhan</au><au>Ma, Huizi</au><au>Pan, Yuesong</au><au>Wang, David</au><au>Wang, Yilong</au><au>Feng, Tao</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Effect of small vessel disease burden and lacunes on gait/posture impairment in Parkinson’s disease</atitle><jtitle>Neurological sciences</jtitle><stitle>Neurol Sci</stitle><addtitle>Neurol Sci</addtitle><date>2020-12-01</date><risdate>2020</risdate><volume>41</volume><issue>12</issue><spage>3617</spage><epage>3624</epage><pages>3617-3624</pages><issn>1590-1874</issn><eissn>1590-3478</eissn><abstract>Introduction
The comorbidity of cerebral small vessel disease (CSVD) may worsen gait impairment of Parkinson’s disease (PD). However, the evidence remains scarce and controversial, and the mechanism of their potential interaction remains largely unknown. The present study aimed to investigate the overall impact of quantity and location of CSVD on gait/posture function in PD.
Methods
This cross-sectional study included 315 consecutive eligible patients with PD from Beijing Tiantan Hospital from May 2016 to August 2018. Associations of gait/posture subscores with the burden score of CSVD and four CSVD imaging markers were assessed using multivariate linear regression models.
Results
Burden of CSVD was significantly associated with more severe gait/posture impairment in PD in the unadjusted model (
β
= 0.521,
P
= 0.011, 95% CI 0.118–0.923) and in the model adjusted for age, hypertension, ischemic stroke, low-density lipoprotein level, cholesterol level, and cognitive statues (
β
= 0.448,
P
= 0.047, 95% CI 0.006–0.891). The presence of lacunes, but not other CSVD markers, was significantly associated with higher gait/posture subscores after the adjustment (
β
= 0.492,
P
= 0.041, 95% CI 0.021–0.964), and the number of lacunes in the basal ganglia significantly correlated with the gait/posture subscores in patients with PD (
P
= 0.012, Spearman
r
= 0.161).
Conclusions
CSVD and lacunes in the basal ganglia may independently contribute to gait/posture dysfunction in PD. Promoting neurovascular health may preserve some gait/posture function of PD.</abstract><cop>Cham</cop><pub>Springer International Publishing</pub><pmid>32458249</pmid><doi>10.1007/s10072-020-04452-z</doi><tpages>8</tpages><orcidid>https://orcid.org/0000-0002-8530-4622</orcidid></addata></record> |
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| language | eng |
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| source | MEDLINE; SpringerLink Journals - AutoHoldings |
| subjects | Basal ganglia Cerebral Small Vessel Diseases - complications Cerebral Small Vessel Diseases - diagnostic imaging Cerebral Small Vessel Diseases - epidemiology Cholesterol Cognitive ability Cost of Illness Cross-Sectional Studies Gait Humans Ischemia Magnetic Resonance Imaging Medicine Medicine & Public Health Movement disorders Neurodegenerative diseases Neurology Neuroradiology Neurosciences Neurosurgery Original Article Parkinson Disease - complications Parkinson Disease - epidemiology Parkinson's disease Posture Psychiatry Regression analysis Vascular diseases |
| title | Effect of small vessel disease burden and lacunes on gait/posture impairment in Parkinson’s disease |
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