The prognostic value of organ/space surgical site infection in stage I colorectal cancer recurrence
Purpose Evidence on risk factors for postoperative recurrence in patients with colorectal cancer (CRC) confined to pathological stage I is limited. Therefore, this study aimed to identify the risk factors for recurrence in patients with stage I CRC. Methods Data on clinicopathological factors and bl...
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| Veröffentlicht in: | International journal of colorectal disease 2020-09, Vol.35 (9), p.1689-1694 |
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| container_title | International journal of colorectal disease |
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| creator | Akabane, Shintaro Egi, Hiroyuki Takakura, Yuji Sada, Haruki Kochi, Masatoshi Taguchi, Kazuhiro Nakashima, Ikki Sumi, Yusuke Sato, Koki Yoshinaka, Hisaaki Hattori, Minoru Ohdan, Hideki |
| description | Purpose
Evidence on risk factors for postoperative recurrence in patients with colorectal cancer (CRC) confined to pathological stage I is limited. Therefore, this study aimed to identify the risk factors for recurrence in patients with stage I CRC.
Methods
Data on clinicopathological factors and blood tests of patients diagnosed with pathological stage I CRC at Hiroshima University Hospital between April 1, 2010, and December 31, 2018, were retrospectively obtained. The statistical significance between the clinical factors and postoperative recurrence was also investigated.
Results
A total of 244 patients were included. The median observation period was 45 months. There were 17 patients (6.6%) with a postoperative recurrence (8 local and 9 distant recurrences). In the log-lank test, rectal cancer (
p
= 0.004), pT2 (
p
= 0.020) and organ/space surgical site infection (SSI) (
p
= 0.008) were significantly associated with postoperative recurrence. In a multivariate analysis, rectal cancer (hazard ratio [HR] 3.678, 95% confidence interval [CI] 1.184–11.425,
p
= 0.024) and organ/space SSI (HR 3.137, 95% CI 1.013–9.713,
p
= 0.047) were independently associated with a higher recurrence rate. Among 18 patients with organ/space SSI, 4 recurrences occurred, all of which were distant metastases.
Conclusion
Organ/space SSI significantly affects the postoperative recurrence in patients with stage I CRC. |
| doi_str_mv | 10.1007/s00384-020-03643-6 |
| format | Article |
| fullrecord | <record><control><sourceid>gale_proqu</sourceid><recordid>TN_cdi_proquest_miscellaneous_2406951275</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><galeid>A714487612</galeid><sourcerecordid>A714487612</sourcerecordid><originalsourceid>FETCH-LOGICAL-c508t-b38c9a463cfe33e1e004b79cbed22fbe4c5b142c27b42021a60bebbd3c91ba403</originalsourceid><addsrcrecordid>eNp9kU1v1DAQhi1ERZfCH-CALHHpJe34I05yrCoolSr1Us6WPTsJqbLxYidI_PtO2UIFQsiH-fDzjmb0CvFOwZkCaM4LgGltBRoqMM6ayr0QG2WNrpR2-qXYgGq6SnV1eyxel3IPXLvGvhLHRttaOdtuBN59JbnPaZhTWUaU38O0kky9THkI83nZByRZ1jyMGCZZxoXkOPeEy5hmzmRZwkDyWmKaUuY2QxhmpCy5WnMmzt-Ioz5Mhd4-xRPx5dPHu8vP1c3t1fXlxU2FNbRLFU2LXbDOYE_GkCIAG5sOI2217iNZrKOyGnUTrQatgoNIMW4NdioGC-ZEnB7m8j3fViqL340FaZrCTGktXltwXa10UzP64S_0Pq155u2YMspBo2z7TA1hIs93pyUHfBzqLxiwbeOUZursHxS_Le1GTDP1I_f_EOiDAHMqJVPv93nchfzDK_CPzvqDs56d9T-d9Y5F7582XuOOtr8lv6xkwByAwl_zQPn5pP-MfQB_uK04</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2431607148</pqid></control><display><type>article</type><title>The prognostic value of organ/space surgical site infection in stage I colorectal cancer recurrence</title><source>SpringerLink Journals</source><creator>Akabane, Shintaro ; Egi, Hiroyuki ; Takakura, Yuji ; Sada, Haruki ; Kochi, Masatoshi ; Taguchi, Kazuhiro ; Nakashima, Ikki ; Sumi, Yusuke ; Sato, Koki ; Yoshinaka, Hisaaki ; Hattori, Minoru ; Ohdan, Hideki</creator><creatorcontrib>Akabane, Shintaro ; Egi, Hiroyuki ; Takakura, Yuji ; Sada, Haruki ; Kochi, Masatoshi ; Taguchi, Kazuhiro ; Nakashima, Ikki ; Sumi, Yusuke ; Sato, Koki ; Yoshinaka, Hisaaki ; Hattori, Minoru ; Ohdan, Hideki</creatorcontrib><description>Purpose
Evidence on risk factors for postoperative recurrence in patients with colorectal cancer (CRC) confined to pathological stage I is limited. Therefore, this study aimed to identify the risk factors for recurrence in patients with stage I CRC.
Methods
Data on clinicopathological factors and blood tests of patients diagnosed with pathological stage I CRC at Hiroshima University Hospital between April 1, 2010, and December 31, 2018, were retrospectively obtained. The statistical significance between the clinical factors and postoperative recurrence was also investigated.
Results
A total of 244 patients were included. The median observation period was 45 months. There were 17 patients (6.6%) with a postoperative recurrence (8 local and 9 distant recurrences). In the log-lank test, rectal cancer (
p
= 0.004), pT2 (
p
= 0.020) and organ/space surgical site infection (SSI) (
p
= 0.008) were significantly associated with postoperative recurrence. In a multivariate analysis, rectal cancer (hazard ratio [HR] 3.678, 95% confidence interval [CI] 1.184–11.425,
p
= 0.024) and organ/space SSI (HR 3.137, 95% CI 1.013–9.713,
p
= 0.047) were independently associated with a higher recurrence rate. Among 18 patients with organ/space SSI, 4 recurrences occurred, all of which were distant metastases.
Conclusion
Organ/space SSI significantly affects the postoperative recurrence in patients with stage I CRC.</description><identifier>ISSN: 0179-1958</identifier><identifier>EISSN: 1432-1262</identifier><identifier>DOI: 10.1007/s00384-020-03643-6</identifier><identifier>PMID: 32451648</identifier><language>eng</language><publisher>Berlin/Heidelberg: Springer Berlin Heidelberg</publisher><subject>Analysis ; Blood ; Cancer ; Cancer patients ; Cefmetazole ; Colorectal cancer ; Colorectal carcinoma ; Diseases ; Gastroenterology ; Health aspects ; Hepatology ; Internal Medicine ; Medical colleges ; Medical examination ; Medicine ; Medicine & Public Health ; Metastases ; Multivariate analysis ; Oncology, Experimental ; Original Article ; Patients ; Proctology ; Prognosis ; Rectum ; Relapse ; Risk factors ; Surgery ; Surgical site infections</subject><ispartof>International journal of colorectal disease, 2020-09, Vol.35 (9), p.1689-1694</ispartof><rights>Springer-Verlag GmbH Germany, part of Springer Nature 2020</rights><rights>COPYRIGHT 2020 Springer</rights><rights>Springer-Verlag GmbH Germany, part of Springer Nature 2020.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c508t-b38c9a463cfe33e1e004b79cbed22fbe4c5b142c27b42021a60bebbd3c91ba403</citedby><cites>FETCH-LOGICAL-c508t-b38c9a463cfe33e1e004b79cbed22fbe4c5b142c27b42021a60bebbd3c91ba403</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s00384-020-03643-6$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s00384-020-03643-6$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,780,784,27924,27925,41488,42557,51319</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/32451648$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Akabane, Shintaro</creatorcontrib><creatorcontrib>Egi, Hiroyuki</creatorcontrib><creatorcontrib>Takakura, Yuji</creatorcontrib><creatorcontrib>Sada, Haruki</creatorcontrib><creatorcontrib>Kochi, Masatoshi</creatorcontrib><creatorcontrib>Taguchi, Kazuhiro</creatorcontrib><creatorcontrib>Nakashima, Ikki</creatorcontrib><creatorcontrib>Sumi, Yusuke</creatorcontrib><creatorcontrib>Sato, Koki</creatorcontrib><creatorcontrib>Yoshinaka, Hisaaki</creatorcontrib><creatorcontrib>Hattori, Minoru</creatorcontrib><creatorcontrib>Ohdan, Hideki</creatorcontrib><title>The prognostic value of organ/space surgical site infection in stage I colorectal cancer recurrence</title><title>International journal of colorectal disease</title><addtitle>Int J Colorectal Dis</addtitle><addtitle>Int J Colorectal Dis</addtitle><description>Purpose
Evidence on risk factors for postoperative recurrence in patients with colorectal cancer (CRC) confined to pathological stage I is limited. Therefore, this study aimed to identify the risk factors for recurrence in patients with stage I CRC.
Methods
Data on clinicopathological factors and blood tests of patients diagnosed with pathological stage I CRC at Hiroshima University Hospital between April 1, 2010, and December 31, 2018, were retrospectively obtained. The statistical significance between the clinical factors and postoperative recurrence was also investigated.
Results
A total of 244 patients were included. The median observation period was 45 months. There were 17 patients (6.6%) with a postoperative recurrence (8 local and 9 distant recurrences). In the log-lank test, rectal cancer (
p
= 0.004), pT2 (
p
= 0.020) and organ/space surgical site infection (SSI) (
p
= 0.008) were significantly associated with postoperative recurrence. In a multivariate analysis, rectal cancer (hazard ratio [HR] 3.678, 95% confidence interval [CI] 1.184–11.425,
p
= 0.024) and organ/space SSI (HR 3.137, 95% CI 1.013–9.713,
p
= 0.047) were independently associated with a higher recurrence rate. Among 18 patients with organ/space SSI, 4 recurrences occurred, all of which were distant metastases.
Conclusion
Organ/space SSI significantly affects the postoperative recurrence in patients with stage I CRC.</description><subject>Analysis</subject><subject>Blood</subject><subject>Cancer</subject><subject>Cancer patients</subject><subject>Cefmetazole</subject><subject>Colorectal cancer</subject><subject>Colorectal carcinoma</subject><subject>Diseases</subject><subject>Gastroenterology</subject><subject>Health aspects</subject><subject>Hepatology</subject><subject>Internal Medicine</subject><subject>Medical colleges</subject><subject>Medical examination</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Metastases</subject><subject>Multivariate analysis</subject><subject>Oncology, Experimental</subject><subject>Original Article</subject><subject>Patients</subject><subject>Proctology</subject><subject>Prognosis</subject><subject>Rectum</subject><subject>Relapse</subject><subject>Risk factors</subject><subject>Surgery</subject><subject>Surgical site infections</subject><issn>0179-1958</issn><issn>1432-1262</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><recordid>eNp9kU1v1DAQhi1ERZfCH-CALHHpJe34I05yrCoolSr1Us6WPTsJqbLxYidI_PtO2UIFQsiH-fDzjmb0CvFOwZkCaM4LgGltBRoqMM6ayr0QG2WNrpR2-qXYgGq6SnV1eyxel3IPXLvGvhLHRttaOdtuBN59JbnPaZhTWUaU38O0kky9THkI83nZByRZ1jyMGCZZxoXkOPeEy5hmzmRZwkDyWmKaUuY2QxhmpCy5WnMmzt-Ioz5Mhd4-xRPx5dPHu8vP1c3t1fXlxU2FNbRLFU2LXbDOYE_GkCIAG5sOI2217iNZrKOyGnUTrQatgoNIMW4NdioGC-ZEnB7m8j3fViqL340FaZrCTGktXltwXa10UzP64S_0Pq155u2YMspBo2z7TA1hIs93pyUHfBzqLxiwbeOUZursHxS_Le1GTDP1I_f_EOiDAHMqJVPv93nchfzDK_CPzvqDs56d9T-d9Y5F7582XuOOtr8lv6xkwByAwl_zQPn5pP-MfQB_uK04</recordid><startdate>20200901</startdate><enddate>20200901</enddate><creator>Akabane, Shintaro</creator><creator>Egi, Hiroyuki</creator><creator>Takakura, Yuji</creator><creator>Sada, Haruki</creator><creator>Kochi, Masatoshi</creator><creator>Taguchi, Kazuhiro</creator><creator>Nakashima, Ikki</creator><creator>Sumi, Yusuke</creator><creator>Sato, Koki</creator><creator>Yoshinaka, Hisaaki</creator><creator>Hattori, Minoru</creator><creator>Ohdan, Hideki</creator><general>Springer Berlin Heidelberg</general><general>Springer</general><general>Springer Nature B.V</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7T5</scope><scope>H94</scope><scope>K9.</scope><scope>7X8</scope></search><sort><creationdate>20200901</creationdate><title>The prognostic value of organ/space surgical site infection in stage I colorectal cancer recurrence</title><author>Akabane, Shintaro ; Egi, Hiroyuki ; Takakura, Yuji ; Sada, Haruki ; Kochi, Masatoshi ; Taguchi, Kazuhiro ; Nakashima, Ikki ; Sumi, Yusuke ; Sato, Koki ; Yoshinaka, Hisaaki ; Hattori, Minoru ; Ohdan, Hideki</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c508t-b38c9a463cfe33e1e004b79cbed22fbe4c5b142c27b42021a60bebbd3c91ba403</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><topic>Analysis</topic><topic>Blood</topic><topic>Cancer</topic><topic>Cancer patients</topic><topic>Cefmetazole</topic><topic>Colorectal cancer</topic><topic>Colorectal carcinoma</topic><topic>Diseases</topic><topic>Gastroenterology</topic><topic>Health aspects</topic><topic>Hepatology</topic><topic>Internal Medicine</topic><topic>Medical colleges</topic><topic>Medical examination</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Metastases</topic><topic>Multivariate analysis</topic><topic>Oncology, Experimental</topic><topic>Original Article</topic><topic>Patients</topic><topic>Proctology</topic><topic>Prognosis</topic><topic>Rectum</topic><topic>Relapse</topic><topic>Risk factors</topic><topic>Surgery</topic><topic>Surgical site infections</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Akabane, Shintaro</creatorcontrib><creatorcontrib>Egi, Hiroyuki</creatorcontrib><creatorcontrib>Takakura, Yuji</creatorcontrib><creatorcontrib>Sada, Haruki</creatorcontrib><creatorcontrib>Kochi, Masatoshi</creatorcontrib><creatorcontrib>Taguchi, Kazuhiro</creatorcontrib><creatorcontrib>Nakashima, Ikki</creatorcontrib><creatorcontrib>Sumi, Yusuke</creatorcontrib><creatorcontrib>Sato, Koki</creatorcontrib><creatorcontrib>Yoshinaka, Hisaaki</creatorcontrib><creatorcontrib>Hattori, Minoru</creatorcontrib><creatorcontrib>Ohdan, Hideki</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>Immunology Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>MEDLINE - Academic</collection><jtitle>International journal of colorectal disease</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Akabane, Shintaro</au><au>Egi, Hiroyuki</au><au>Takakura, Yuji</au><au>Sada, Haruki</au><au>Kochi, Masatoshi</au><au>Taguchi, Kazuhiro</au><au>Nakashima, Ikki</au><au>Sumi, Yusuke</au><au>Sato, Koki</au><au>Yoshinaka, Hisaaki</au><au>Hattori, Minoru</au><au>Ohdan, Hideki</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The prognostic value of organ/space surgical site infection in stage I colorectal cancer recurrence</atitle><jtitle>International journal of colorectal disease</jtitle><stitle>Int J Colorectal Dis</stitle><addtitle>Int J Colorectal Dis</addtitle><date>2020-09-01</date><risdate>2020</risdate><volume>35</volume><issue>9</issue><spage>1689</spage><epage>1694</epage><pages>1689-1694</pages><issn>0179-1958</issn><eissn>1432-1262</eissn><abstract>Purpose
Evidence on risk factors for postoperative recurrence in patients with colorectal cancer (CRC) confined to pathological stage I is limited. Therefore, this study aimed to identify the risk factors for recurrence in patients with stage I CRC.
Methods
Data on clinicopathological factors and blood tests of patients diagnosed with pathological stage I CRC at Hiroshima University Hospital between April 1, 2010, and December 31, 2018, were retrospectively obtained. The statistical significance between the clinical factors and postoperative recurrence was also investigated.
Results
A total of 244 patients were included. The median observation period was 45 months. There were 17 patients (6.6%) with a postoperative recurrence (8 local and 9 distant recurrences). In the log-lank test, rectal cancer (
p
= 0.004), pT2 (
p
= 0.020) and organ/space surgical site infection (SSI) (
p
= 0.008) were significantly associated with postoperative recurrence. In a multivariate analysis, rectal cancer (hazard ratio [HR] 3.678, 95% confidence interval [CI] 1.184–11.425,
p
= 0.024) and organ/space SSI (HR 3.137, 95% CI 1.013–9.713,
p
= 0.047) were independently associated with a higher recurrence rate. Among 18 patients with organ/space SSI, 4 recurrences occurred, all of which were distant metastases.
Conclusion
Organ/space SSI significantly affects the postoperative recurrence in patients with stage I CRC.</abstract><cop>Berlin/Heidelberg</cop><pub>Springer Berlin Heidelberg</pub><pmid>32451648</pmid><doi>10.1007/s00384-020-03643-6</doi><tpages>6</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0179-1958 |
| ispartof | International journal of colorectal disease, 2020-09, Vol.35 (9), p.1689-1694 |
| issn | 0179-1958 1432-1262 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_2406951275 |
| source | SpringerLink Journals |
| subjects | Analysis Blood Cancer Cancer patients Cefmetazole Colorectal cancer Colorectal carcinoma Diseases Gastroenterology Health aspects Hepatology Internal Medicine Medical colleges Medical examination Medicine Medicine & Public Health Metastases Multivariate analysis Oncology, Experimental Original Article Patients Proctology Prognosis Rectum Relapse Risk factors Surgery Surgical site infections |
| title | The prognostic value of organ/space surgical site infection in stage I colorectal cancer recurrence |
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