Identification of Tumor Antigens in the HLA Peptidome of Patient-derived Xenograft Tumors in Mouse

Sufficient tumor tissues are often not available for large HLA peptidome analysis. We demonstrate here that using patient derived xenograft (PDX) tumors are a useful source of large tumors for obtaining detailed and authentic HLA peptidomes that enable identification of many tumor antigens and even...

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Veröffentlicht in:	Molecular & cellular proteomics 2020-08, Vol.19 (8), p.1360-1374
Hauptverfasser:	Rijensky, Nataly Mancette, Blondheim Shraga, Netta R., Barnea, Eilon, Peled, Nir, Rosenbaum, Eli, Popovtzer, Aron, Stemmer, Solomon M., Livoff, Alejandro, Shlapobersky, Mark, Moskovits, Neta, Perry, Dafna, Rubin, Eitan, Haviv, Itzhak, Admon, Arie
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antigens, Neoplasm - metabolism Biopsy cancer biomarker(s) cancer/testis antigens clinical proteomics Cluster Analysis Female HLA Antigens - metabolism human leukocyte antigen Humans immunology Male Mass spectrometry MHC, major histocompatibility complex Mice Mutation - genetics PDX, patient-derived xenograft tumors peptides Peptides - metabolism peptidome peptidomics personalized medicine Proteome - metabolism Xenograft Model Antitumor Assays
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