Diagnostic value of retrospectively fused 64CuCl2 PET/MRI in biochemical relapse of prostate cancer: comparison with fused 18F-Choline PET/MRI, 64CuCl2 PET/CT, 18F-Choline PET/CT, and mpMRI

Purpose To assess the diagnostic value of retrospectively fused PET/MRI by comparing the detection rates (DRs) of fused 64 CuCl 2  PET/MRI vs. fused 18 F-Choline PET/MRI in patients with suspected prostatic cancer (PCa) recurrence. The secondary objective was to compare the DRs of fused PET/MRI vs....

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Veröffentlicht in:Abdominal imaging 2020-11, Vol.45 (11), p.3896-3906
Hauptverfasser: Paparo, Francesco, Peirano, Alice, Matos, João, Bacigalupo, Lorenzo, Rossi, Umberto, Mussetto, Ilaria, Bottoni, Gianluca, Ugolini, Martina, Introini, Carlo, Ruggieri, Filippo Grillo, Rollandi, Gian Andrea, Piccardo, Arnoldo
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container_end_page 3906
container_issue 11
container_start_page 3896
container_title Abdominal imaging
container_volume 45
creator Paparo, Francesco
Peirano, Alice
Matos, João
Bacigalupo, Lorenzo
Rossi, Umberto
Mussetto, Ilaria
Bottoni, Gianluca
Ugolini, Martina
Introini, Carlo
Ruggieri, Filippo Grillo
Rollandi, Gian Andrea
Piccardo, Arnoldo
description Purpose To assess the diagnostic value of retrospectively fused PET/MRI by comparing the detection rates (DRs) of fused 64 CuCl 2  PET/MRI vs. fused 18 F-Choline PET/MRI in patients with suspected prostatic cancer (PCa) recurrence. The secondary objective was to compare the DRs of fused PET/MRI vs. those of the separate imaging modalities. Methods We retrospectively evaluated 50 PCa patients with biochemical relapse after radical prostatectomy (RP) or radiotherapy (RT). All patients underwent  64 CuCl 2  PET/CT,  18 F-Choline PET/CT, and multiparametric magnetic resonance imaging (mpMRI) within 15 days. Fused  64 CuCl 2 -PET/MRI and fused  18 F-Choline PET/MRI images were obtained by retrospective co-registration of MRI and PET images. Experienced readers interpreted the images, and the DRs of each imaging modality were assessed. Results In the patient-based analysis, overall DRs of fused 64 CuCl 2 PET/MRI, fused  18 F-Choline PET/MRI,  64 CuCl 2  PET/CT,  18 F-Choline PET/CT, and mpMRI were 88%, 68%, 82%, 56%, and 74%, respectively. In the lesion-based analysis, overall DRs of fused  64 CuCl 2  PET/MRI, fused  18 F-Choline PET/MRI,  64 CuCl 2  PET/CT, 18  F-Choline PET/CT, and mpMRI were 95%, 66%, 87%, 58%, and 71%, respectively. Conclusions Retrospectively fused PET/MRI is able to overcome the limitations of the separate interpretation of the individual imaging modalities. Fused 64 CuCl 2  PET/MRI provided the highest diagnostic performance in the detection of PCa local relapse.
doi_str_mv 10.1007/s00261-020-02591-7
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The secondary objective was to compare the DRs of fused PET/MRI vs. those of the separate imaging modalities. Methods We retrospectively evaluated 50 PCa patients with biochemical relapse after radical prostatectomy (RP) or radiotherapy (RT). All patients underwent  64 CuCl 2  PET/CT,  18 F-Choline PET/CT, and multiparametric magnetic resonance imaging (mpMRI) within 15 days. Fused  64 CuCl 2 -PET/MRI and fused  18 F-Choline PET/MRI images were obtained by retrospective co-registration of MRI and PET images. Experienced readers interpreted the images, and the DRs of each imaging modality were assessed. Results In the patient-based analysis, overall DRs of fused 64 CuCl 2 PET/MRI, fused  18 F-Choline PET/MRI,  64 CuCl 2  PET/CT,  18 F-Choline PET/CT, and mpMRI were 88%, 68%, 82%, 56%, and 74%, respectively. In the lesion-based analysis, overall DRs of fused  64 CuCl 2  PET/MRI, fused  18 F-Choline PET/MRI,  64 CuCl 2  PET/CT, 18  F-Choline PET/CT, and mpMRI were 95%, 66%, 87%, 58%, and 71%, respectively. Conclusions Retrospectively fused PET/MRI is able to overcome the limitations of the separate interpretation of the individual imaging modalities. Fused 64 CuCl 2  PET/MRI provided the highest diagnostic performance in the detection of PCa local relapse.</description><identifier>ISSN: 2366-004X</identifier><identifier>EISSN: 2366-0058</identifier><identifier>DOI: 10.1007/s00261-020-02591-7</identifier><language>eng</language><publisher>New York: Springer US</publisher><subject>Cancer surgery ; Choline ; Computed tomography ; Diagnostic systems ; Fluorine isotopes ; Gastroenterology ; Hepatology ; Imaging ; Magnetic resonance imaging ; Medical diagnosis ; Medical imaging ; Medicine ; Medicine &amp; Public Health ; Pelvis ; Positron emission ; Prostate cancer ; Prostatectomy ; Radiation therapy ; Radiology ; Tomography</subject><ispartof>Abdominal imaging, 2020-11, Vol.45 (11), p.3896-3906</ispartof><rights>Springer Science+Business Media, LLC, part of Springer Nature 2020</rights><rights>Springer Science+Business Media, LLC, part of Springer Nature 2020.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c1977-2615010ffa56db89951f03ca35061610597953651ed8cde49f14a84ca4cfbcf13</citedby><cites>FETCH-LOGICAL-c1977-2615010ffa56db89951f03ca35061610597953651ed8cde49f14a84ca4cfbcf13</cites><orcidid>0000-0002-2391-0635</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s00261-020-02591-7$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s00261-020-02591-7$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,777,781,27905,27906,41469,42538,51300</link.rule.ids></links><search><creatorcontrib>Paparo, Francesco</creatorcontrib><creatorcontrib>Peirano, Alice</creatorcontrib><creatorcontrib>Matos, João</creatorcontrib><creatorcontrib>Bacigalupo, Lorenzo</creatorcontrib><creatorcontrib>Rossi, Umberto</creatorcontrib><creatorcontrib>Mussetto, Ilaria</creatorcontrib><creatorcontrib>Bottoni, Gianluca</creatorcontrib><creatorcontrib>Ugolini, Martina</creatorcontrib><creatorcontrib>Introini, Carlo</creatorcontrib><creatorcontrib>Ruggieri, Filippo Grillo</creatorcontrib><creatorcontrib>Rollandi, Gian Andrea</creatorcontrib><creatorcontrib>Piccardo, Arnoldo</creatorcontrib><title>Diagnostic value of retrospectively fused 64CuCl2 PET/MRI in biochemical relapse of prostate cancer: comparison with fused 18F-Choline PET/MRI, 64CuCl2 PET/CT, 18F-Choline PET/CT, and mpMRI</title><title>Abdominal imaging</title><addtitle>Abdom Radiol</addtitle><description>Purpose To assess the diagnostic value of retrospectively fused PET/MRI by comparing the detection rates (DRs) of fused 64 CuCl 2  PET/MRI vs. fused 18 F-Choline PET/MRI in patients with suspected prostatic cancer (PCa) recurrence. The secondary objective was to compare the DRs of fused PET/MRI vs. those of the separate imaging modalities. Methods We retrospectively evaluated 50 PCa patients with biochemical relapse after radical prostatectomy (RP) or radiotherapy (RT). All patients underwent  64 CuCl 2  PET/CT,  18 F-Choline PET/CT, and multiparametric magnetic resonance imaging (mpMRI) within 15 days. Fused  64 CuCl 2 -PET/MRI and fused  18 F-Choline PET/MRI images were obtained by retrospective co-registration of MRI and PET images. Experienced readers interpreted the images, and the DRs of each imaging modality were assessed. Results In the patient-based analysis, overall DRs of fused 64 CuCl 2 PET/MRI, fused  18 F-Choline PET/MRI,  64 CuCl 2  PET/CT,  18 F-Choline PET/CT, and mpMRI were 88%, 68%, 82%, 56%, and 74%, respectively. 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The secondary objective was to compare the DRs of fused PET/MRI vs. those of the separate imaging modalities. Methods We retrospectively evaluated 50 PCa patients with biochemical relapse after radical prostatectomy (RP) or radiotherapy (RT). All patients underwent  64 CuCl 2  PET/CT,  18 F-Choline PET/CT, and multiparametric magnetic resonance imaging (mpMRI) within 15 days. Fused  64 CuCl 2 -PET/MRI and fused  18 F-Choline PET/MRI images were obtained by retrospective co-registration of MRI and PET images. Experienced readers interpreted the images, and the DRs of each imaging modality were assessed. Results In the patient-based analysis, overall DRs of fused 64 CuCl 2 PET/MRI, fused  18 F-Choline PET/MRI,  64 CuCl 2  PET/CT,  18 F-Choline PET/CT, and mpMRI were 88%, 68%, 82%, 56%, and 74%, respectively. In the lesion-based analysis, overall DRs of fused  64 CuCl 2  PET/MRI, fused  18 F-Choline PET/MRI,  64 CuCl 2  PET/CT, 18  F-Choline PET/CT, and mpMRI were 95%, 66%, 87%, 58%, and 71%, respectively. Conclusions Retrospectively fused PET/MRI is able to overcome the limitations of the separate interpretation of the individual imaging modalities. Fused 64 CuCl 2  PET/MRI provided the highest diagnostic performance in the detection of PCa local relapse.</abstract><cop>New York</cop><pub>Springer US</pub><doi>10.1007/s00261-020-02591-7</doi><tpages>11</tpages><orcidid>https://orcid.org/0000-0002-2391-0635</orcidid></addata></record>
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subjects Cancer surgery
Choline
Computed tomography
Diagnostic systems
Fluorine isotopes
Gastroenterology
Hepatology
Imaging
Magnetic resonance imaging
Medical diagnosis
Medical imaging
Medicine
Medicine & Public Health
Pelvis
Positron emission
Prostate cancer
Prostatectomy
Radiation therapy
Radiology
Tomography
title Diagnostic value of retrospectively fused 64CuCl2 PET/MRI in biochemical relapse of prostate cancer: comparison with fused 18F-Choline PET/MRI, 64CuCl2 PET/CT, 18F-Choline PET/CT, and mpMRI
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