Association of glomerular hyperfiltration with serum chemokine levels and metabolic features in prepubertal children with overweight/obesity
Glomerular hyperfiltration (GH) is proposed as one of the earliest events in obesity (OB)-associated renal disease. Children with GH and type-1 diabetes showed increased chemokine levels. Chemokine associations with glomerular filtration rate (GFR) and metabolic features in prepubertal children with...
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| creator | Muzzio, María L. Kabakian, María L. Morosán-Allo, Yanina Ferrari, Silvia Fallahi, Poupak Fernández, Jorgelina Santucci, María P. Andrés-Lacueva, Cristina Antonelli, Alessandro Brenta, Gabriela Meroño, Tomás |
| description | Glomerular hyperfiltration (GH) is proposed as one of the earliest events in obesity (OB)-associated renal disease. Children with GH and type-1 diabetes showed increased chemokine levels. Chemokine associations with glomerular filtration rate (GFR) and metabolic features in prepubertal children with overweight (OW)/OB are unknown.
Cross-sectional study. 75 prepubertal children (aged: 9.0 ± 1.7 years) with OW/OB were studied. Clinical and metabolic characteristics (including non-esterified fatty acids, NEFA) and GFR (combined Zappitelli equation) were assessed. GH was defined as GFR >135 ml/min.1.73 m2. Serum levels of regulated on activation, normal T cell expressed and secreted (RANTES)/CCL5, interleukin-8 (IL-8)/CXCL8 and monokine-induced by interferon-γ (MIG)/CXCL9 were measured by ELISA. Age- and sex-adjusted correlations and differences were tested. 48% of the cohort was female and 13% were OW, 54% OB and 33% severe OB. Prepubertal children with GH showed lower z-BMI (−12%), NEFA (−26%) and uric acid (−22%) than those without GH (all p 0.05). Adjusted correlations were significant for RANTES and z-BMI (r = 0.26; p |
| doi_str_mv | 10.1016/j.numecd.2020.03.012 |
| format | Article |
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Cross-sectional study. 75 prepubertal children (aged: 9.0 ± 1.7 years) with OW/OB were studied. Clinical and metabolic characteristics (including non-esterified fatty acids, NEFA) and GFR (combined Zappitelli equation) were assessed. GH was defined as GFR >135 ml/min.1.73 m2. Serum levels of regulated on activation, normal T cell expressed and secreted (RANTES)/CCL5, interleukin-8 (IL-8)/CXCL8 and monokine-induced by interferon-γ (MIG)/CXCL9 were measured by ELISA. Age- and sex-adjusted correlations and differences were tested. 48% of the cohort was female and 13% were OW, 54% OB and 33% severe OB. Prepubertal children with GH showed lower z-BMI (−12%), NEFA (−26%) and uric acid (−22%) than those without GH (all p < 0.05). Similarly to high sensitivity C-reactive protein (hsCRP), there were no differences in serum chemokines between children with GH or not (all p > 0.05). Adjusted correlations were significant for RANTES and z-BMI (r = 0.26; p < 0.05) and for MIG with z-BMI (r = −0.26; p < 0.05) and with NEFA (r = 0.27; p < 0.05).
GH was not associated with higher chemokine levels in prepubertal children with OW/OB. Decreased rather than elevated GFR values were correlated with obesity and worse metabolic profiles. Chemokines levels in children with severe OB suggest a regulation of the immune response. Follow-up studies are needed to address the clinical implications of these findings.
•Early stages of renal disease in obesity (OB) include glomerular hyperfiltration.•Chemokines were not correlated with renal function in prepubertal children with OB.•Renal function decreased in parallel with OB and worse metabolic profiles.•Chemokine levels suggested a regulation of the immune response in severe obesity.</description><identifier>ISSN: 0939-4753</identifier><identifier>EISSN: 1590-3729</identifier><identifier>DOI: 10.1016/j.numecd.2020.03.012</identifier><identifier>PMID: 32448719</identifier><language>eng</language><publisher>Netherlands: Elsevier B.V</publisher><subject>Chemokines ; Children ; Hyperfiltration ; Obesity ; Renal disease</subject><ispartof>Nutrition, metabolism, and cardiovascular diseases, 2020-06, Vol.30 (7), p.1188-1195</ispartof><rights>2020 The Italian Diabetes Society, the Italian Society for the Study of Atherosclerosis, the Italian Society of Human Nutrition and the Department of Clinical Medicine and Surgery, Federico II University</rights><rights>Copyright © 2020 The Italian Diabetes Society, the Italian Society for the Study of Atherosclerosis, the Italian Society of Human Nutrition and the Department of Clinical Medicine and Surgery, Federico II University. Published by Elsevier B.V. All rights reserved.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c408t-360caae1298e0674a910bcbb8fe657bb1b4005d22a0595ca707487123091a5a3</citedby><cites>FETCH-LOGICAL-c408t-360caae1298e0674a910bcbb8fe657bb1b4005d22a0595ca707487123091a5a3</cites><orcidid>0000-0002-5211-6342 ; 0000-0002-5455-4186 ; 0000-0002-5777-3384</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.numecd.2020.03.012$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,778,782,3539,27913,27914,45984</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/32448719$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Muzzio, María L.</creatorcontrib><creatorcontrib>Kabakian, María L.</creatorcontrib><creatorcontrib>Morosán-Allo, Yanina</creatorcontrib><creatorcontrib>Ferrari, Silvia</creatorcontrib><creatorcontrib>Fallahi, Poupak</creatorcontrib><creatorcontrib>Fernández, Jorgelina</creatorcontrib><creatorcontrib>Santucci, María P.</creatorcontrib><creatorcontrib>Andrés-Lacueva, Cristina</creatorcontrib><creatorcontrib>Antonelli, Alessandro</creatorcontrib><creatorcontrib>Brenta, Gabriela</creatorcontrib><creatorcontrib>Meroño, Tomás</creatorcontrib><title>Association of glomerular hyperfiltration with serum chemokine levels and metabolic features in prepubertal children with overweight/obesity</title><title>Nutrition, metabolism, and cardiovascular diseases</title><addtitle>Nutr Metab Cardiovasc Dis</addtitle><description>Glomerular hyperfiltration (GH) is proposed as one of the earliest events in obesity (OB)-associated renal disease. Children with GH and type-1 diabetes showed increased chemokine levels. Chemokine associations with glomerular filtration rate (GFR) and metabolic features in prepubertal children with overweight (OW)/OB are unknown.
Cross-sectional study. 75 prepubertal children (aged: 9.0 ± 1.7 years) with OW/OB were studied. Clinical and metabolic characteristics (including non-esterified fatty acids, NEFA) and GFR (combined Zappitelli equation) were assessed. GH was defined as GFR >135 ml/min.1.73 m2. Serum levels of regulated on activation, normal T cell expressed and secreted (RANTES)/CCL5, interleukin-8 (IL-8)/CXCL8 and monokine-induced by interferon-γ (MIG)/CXCL9 were measured by ELISA. Age- and sex-adjusted correlations and differences were tested. 48% of the cohort was female and 13% were OW, 54% OB and 33% severe OB. Prepubertal children with GH showed lower z-BMI (−12%), NEFA (−26%) and uric acid (−22%) than those without GH (all p < 0.05). Similarly to high sensitivity C-reactive protein (hsCRP), there were no differences in serum chemokines between children with GH or not (all p > 0.05). Adjusted correlations were significant for RANTES and z-BMI (r = 0.26; p < 0.05) and for MIG with z-BMI (r = −0.26; p < 0.05) and with NEFA (r = 0.27; p < 0.05).
GH was not associated with higher chemokine levels in prepubertal children with OW/OB. Decreased rather than elevated GFR values were correlated with obesity and worse metabolic profiles. Chemokines levels in children with severe OB suggest a regulation of the immune response. Follow-up studies are needed to address the clinical implications of these findings.
•Early stages of renal disease in obesity (OB) include glomerular hyperfiltration.•Chemokines were not correlated with renal function in prepubertal children with OB.•Renal function decreased in parallel with OB and worse metabolic profiles.•Chemokine levels suggested a regulation of the immune response in severe obesity.</description><subject>Chemokines</subject><subject>Children</subject><subject>Hyperfiltration</subject><subject>Obesity</subject><subject>Renal disease</subject><issn>0939-4753</issn><issn>1590-3729</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><recordid>eNp9Uctu1DAUtRCITgt_gJCXbJJe28l4vEGqKl5SJTbdW7Zz0_HgxMF2ppp_6EeTUQaWrO7ivHTPIeQDg5oB294e6nEe0HU1Bw41iBoYf0U2rFVQCcnVa7IBJVTVyFZckeucDwBCgmjekivBm2YnmdqQl7uco_Om-DjS2NOnEAdMczCJ7k8Tpt6Hklb02Zc9zQs4ULfHIf7yI9KARwyZmrGjAxZjY_CO9mjKnDBTP9Ip4TRbTMWEReZDl_BiFY-YntE_7ctttJh9Ob0jb3oTMr6_3Bvy-PXL4_336uHntx_3dw-Va2BXKrEFZwwyrnYIW9kYxcA6a3c9bltpLbMNQNtxbqBVrTMS5PlbLkAx0xpxQz6ttlOKv2fMRQ8-OwzBjBjnrHkDi4-SAhZqs1Jdijkn7PWU_GDSSTPQ5xn0Qa8z6PMMGoReZlhkHy8Jsx2w-yf62_tC-LwSlvLw6DHp7DyODjuf0BXdRf__hD-w8Z6n</recordid><startdate>20200625</startdate><enddate>20200625</enddate><creator>Muzzio, María L.</creator><creator>Kabakian, María L.</creator><creator>Morosán-Allo, Yanina</creator><creator>Ferrari, Silvia</creator><creator>Fallahi, Poupak</creator><creator>Fernández, Jorgelina</creator><creator>Santucci, María P.</creator><creator>Andrés-Lacueva, Cristina</creator><creator>Antonelli, Alessandro</creator><creator>Brenta, Gabriela</creator><creator>Meroño, Tomás</creator><general>Elsevier B.V</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0002-5211-6342</orcidid><orcidid>https://orcid.org/0000-0002-5455-4186</orcidid><orcidid>https://orcid.org/0000-0002-5777-3384</orcidid></search><sort><creationdate>20200625</creationdate><title>Association of glomerular hyperfiltration with serum chemokine levels and metabolic features in prepubertal children with overweight/obesity</title><author>Muzzio, María L. ; Kabakian, María L. ; Morosán-Allo, Yanina ; Ferrari, Silvia ; Fallahi, Poupak ; Fernández, Jorgelina ; Santucci, María P. ; Andrés-Lacueva, Cristina ; Antonelli, Alessandro ; Brenta, Gabriela ; Meroño, Tomás</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c408t-360caae1298e0674a910bcbb8fe657bb1b4005d22a0595ca707487123091a5a3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><topic>Chemokines</topic><topic>Children</topic><topic>Hyperfiltration</topic><topic>Obesity</topic><topic>Renal disease</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Muzzio, María L.</creatorcontrib><creatorcontrib>Kabakian, María L.</creatorcontrib><creatorcontrib>Morosán-Allo, Yanina</creatorcontrib><creatorcontrib>Ferrari, Silvia</creatorcontrib><creatorcontrib>Fallahi, Poupak</creatorcontrib><creatorcontrib>Fernández, Jorgelina</creatorcontrib><creatorcontrib>Santucci, María P.</creatorcontrib><creatorcontrib>Andrés-Lacueva, Cristina</creatorcontrib><creatorcontrib>Antonelli, Alessandro</creatorcontrib><creatorcontrib>Brenta, Gabriela</creatorcontrib><creatorcontrib>Meroño, Tomás</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Nutrition, metabolism, and cardiovascular diseases</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Muzzio, María L.</au><au>Kabakian, María L.</au><au>Morosán-Allo, Yanina</au><au>Ferrari, Silvia</au><au>Fallahi, Poupak</au><au>Fernández, Jorgelina</au><au>Santucci, María P.</au><au>Andrés-Lacueva, Cristina</au><au>Antonelli, Alessandro</au><au>Brenta, Gabriela</au><au>Meroño, Tomás</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Association of glomerular hyperfiltration with serum chemokine levels and metabolic features in prepubertal children with overweight/obesity</atitle><jtitle>Nutrition, metabolism, and cardiovascular diseases</jtitle><addtitle>Nutr Metab Cardiovasc Dis</addtitle><date>2020-06-25</date><risdate>2020</risdate><volume>30</volume><issue>7</issue><spage>1188</spage><epage>1195</epage><pages>1188-1195</pages><issn>0939-4753</issn><eissn>1590-3729</eissn><abstract>Glomerular hyperfiltration (GH) is proposed as one of the earliest events in obesity (OB)-associated renal disease. Children with GH and type-1 diabetes showed increased chemokine levels. Chemokine associations with glomerular filtration rate (GFR) and metabolic features in prepubertal children with overweight (OW)/OB are unknown.
Cross-sectional study. 75 prepubertal children (aged: 9.0 ± 1.7 years) with OW/OB were studied. Clinical and metabolic characteristics (including non-esterified fatty acids, NEFA) and GFR (combined Zappitelli equation) were assessed. GH was defined as GFR >135 ml/min.1.73 m2. Serum levels of regulated on activation, normal T cell expressed and secreted (RANTES)/CCL5, interleukin-8 (IL-8)/CXCL8 and monokine-induced by interferon-γ (MIG)/CXCL9 were measured by ELISA. Age- and sex-adjusted correlations and differences were tested. 48% of the cohort was female and 13% were OW, 54% OB and 33% severe OB. Prepubertal children with GH showed lower z-BMI (−12%), NEFA (−26%) and uric acid (−22%) than those without GH (all p < 0.05). Similarly to high sensitivity C-reactive protein (hsCRP), there were no differences in serum chemokines between children with GH or not (all p > 0.05). Adjusted correlations were significant for RANTES and z-BMI (r = 0.26; p < 0.05) and for MIG with z-BMI (r = −0.26; p < 0.05) and with NEFA (r = 0.27; p < 0.05).
GH was not associated with higher chemokine levels in prepubertal children with OW/OB. Decreased rather than elevated GFR values were correlated with obesity and worse metabolic profiles. Chemokines levels in children with severe OB suggest a regulation of the immune response. Follow-up studies are needed to address the clinical implications of these findings.
•Early stages of renal disease in obesity (OB) include glomerular hyperfiltration.•Chemokines were not correlated with renal function in prepubertal children with OB.•Renal function decreased in parallel with OB and worse metabolic profiles.•Chemokine levels suggested a regulation of the immune response in severe obesity.</abstract><cop>Netherlands</cop><pub>Elsevier B.V</pub><pmid>32448719</pmid><doi>10.1016/j.numecd.2020.03.012</doi><tpages>8</tpages><orcidid>https://orcid.org/0000-0002-5211-6342</orcidid><orcidid>https://orcid.org/0000-0002-5455-4186</orcidid><orcidid>https://orcid.org/0000-0002-5777-3384</orcidid><oa>free_for_read</oa></addata></record> |
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| source | ScienceDirect Journals (5 years ago - present) |
| subjects | Chemokines Children Hyperfiltration Obesity Renal disease |
| title | Association of glomerular hyperfiltration with serum chemokine levels and metabolic features in prepubertal children with overweight/obesity |
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