Crosstalk between ER stress, NLRP3 inflammasome, and inflammation

Endoplasmic reticulum stress (ERS) is a protective response to restore protein homeostasis by activating the unfolded protein response (UPR). However, UPR can trigger cell death under severe and/or persistently high ERS. The NLRP3 inflammasome is a complex of multiple proteins that activates the sec...

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Veröffentlicht in:	Applied microbiology and biotechnology 2020-07, Vol.104 (14), p.6129-6140
Hauptverfasser:	Li, Wei, Cao, Ting, Luo, Chunyi, Cai, Jialun, Zhou, Xiangping, Xiao, Xinhua, Liu, Shuangquan
Format:	Artikel
Sprache:	eng
Schlagworte:	Activation Animals Biomedical and Life Sciences Biotechnology Calcium - metabolism Calcium homeostasis Caspase-1 Causes of Cell death Cell interaction Control Crosstalk Cytokines Endoplasmic reticulum Endoplasmic Reticulum Stress Homeostasis Humans IL-1β Inflammasomes Inflammasomes - metabolism Inflammation Inflammation - metabolism Inflammation - pathology Inflammatory diseases Life Sciences Microbial Genetics and Genomics Microbiology Mini-Review NF-kappa B - metabolism NF-κB protein NLR Family, Pyrin Domain-Containing 3 Protein - metabolism NLRP3 Observations Oxidative Stress Physiological aspects Protein folding Proteins Proteostasis Signal Transduction Stress (Physiology) Therapeutic applications Unfolded Protein Response
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