Anti-breast cancer and toxicity studies of total secondary saponin from Anemone raddeana Rhizome on MCF-7 cells via ROS generation and PI3K/AKT/mTOR inactivation

The rhizome of Anemone raddeana Regel (A. raddeana) is a famous traditional Chinese medicine (TCM) recorded in Chinese Pharmacopoeia for the treatment of carbuncle and swelling. Carbuncle swollen is an explanation of tumor in the theory of TCM and softening and resolving hard mass effects are one of...

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Veröffentlicht in:	Journal of ethnopharmacology 2020-09, Vol.259, p.112984, Article 112984
Hauptverfasser:	Zhang, Dandan, Zhang, Qiao, Zheng, Yunliang, Lu, Jincai
Format:	Artikel
Sprache:	eng
Schlagworte:	A549 Cells Anemone - chemistry Anemone - toxicity Anemone raddeana Animals Antineoplastic Agents, Phytogenic - isolation & purification Antineoplastic Agents, Phytogenic - pharmacology Antineoplastic Agents, Phytogenic - toxicity Apoptosis - drug effects Apoptosis Regulatory Proteins - metabolism Breast Neoplasms - drug therapy Breast Neoplasms - enzymology Breast Neoplasms - pathology Cell Cycle Checkpoints - drug effects Cell Proliferation - drug effects Female Hep G2 Cells HPLC-Q/TOF-MS Humans MCF-7 MCF-7 Cells Mice, Inbred BALB C Mice, Nude Mitochondria - drug effects Mitochondria - metabolism Mitochondria - pathology Phosphatidylinositol 3-Kinase - metabolism Plant Extracts - isolation & purification Plant Extracts - pharmacology Plant Extracts - toxicity Proto-Oncogene Proteins c-akt - metabolism Reactive Oxygen Species - metabolism Rhizome - chemistry Rhizome - toxicity Saponins - isolation & purification Saponins - pharmacology Saponins - toxicity Signal Transduction TOR Serine-Threonine Kinases - metabolism Total secondary saponin Toxicity Tumor Burden - drug effects Xenograft Model Antitumor Assays
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