Cell surface IL‐1α trafficking is specifically inhibited by interferon‐γ, and associates with the membrane via IL‐1R2 and GPI anchors

IL‐1 is a powerful cytokine that drives inflammation and modulates adaptive immunity. Both IL‐1α and IL‐1β are translated as proforms that require cleavage for full cytokine activity and release, while IL‐1α is reported to occur as an alternative plasma membrane‐associated form on many cell types. H...

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Veröffentlicht in:	European journal of immunology 2020-11, Vol.50 (11), p.1663-1675
Hauptverfasser:	Chan, Julie N.E., Humphry, Melanie, Kitt, Lauren, Krzyzanska, Dominika, Filbey, Kara J., Bennett, Martin R., Clarke, Murray C.H.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adaptive immunity Animals Cell Membrane - metabolism Cell surface Cytokines Glycosylphosphatidylinositol Glycosylphosphatidylinositols - metabolism Humans IL‐1 Inflammation Inflammation - metabolism Innate immunity Interferon Interferon-gamma - metabolism Interleukin-1alpha - metabolism Macrophage Macrophages Macrophages - metabolism Male Membrane trafficking Mice Mice, Inbred C57BL Phenotypes Protein Binding - physiology Protein biosynthesis Protein transport Protein Transport - physiology Receptors, Interleukin-1 Type II - metabolism
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