A simple method for determining compound affinity and chemical yield from DNA-encoded library selections

DNA-encoded libraries (DELs) can contain billions of unique chemical species; selecting against such large inputs, it is typical to find more candidate binders than is reasonable to pursue for follow-up synthesis and testing. Given this wealth of choices, common practice is to limit synthesis to onl...

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Veröffentlicht in:	Biochemical and biophysical research communications 2020-06, Vol.527 (1), p.250-256
Hauptverfasser:	Hall, Justin, Foley, Timothy L., Chen, Qiuxia, Israel, David I., Xu, Yanshan, Ford, Kristin K., Xie, Ping, Fan, Jing, Wan, Jinqiao
Format:	Artikel
Sprache:	eng
Schlagworte:	Cell Cycle Proteins - chemistry Combinatorial Chemistry Techniques DEL DNA - chemistry DNA-Encoded libraries Drug discovery Gene Library Hit identification Humans Lead discovery rho-Associated Kinases - chemistry Transcription Factors - chemistry
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