Antioxidants suppress radiation-induced apoptosis via inhibiting MAPK pathway in nasopharyngeal carcinoma cells

Nasopharyngeal carcinoma (NPC) is relatively sensitive to ionizing radiation, and radiotherapy is the main treatment modality for non-metastatic NPC. Radiation therapy generates overproduction of reactive oxygen species (ROS), which can cause DNA damage and induce apoptosis in tumors, thereby killin...

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Veröffentlicht in:	Biochemical and biophysical research communications 2020-06, Vol.527 (3), p.770-777
Hauptverfasser:	Meng, Dong-Fang, Guo, Ling-Ling, Peng, Li-Xia, Zheng, Li-Sheng, Xie, Ping, Mei, Yan, Li, Chang-Zhi, Peng, Xing-Si, Lang, Yan-Hong, Liu, Zhi-Jie, Wang, Ming-Dian, Xie, De-Huan, Shu, Di-Tian, Hu, Hao, Lin, Si-Ting, Li, Hai-Feng, Luo, Fei-Fei, Sun, Rui, Huang, Bi-Jun, Qian, Chao-Nan
Format:	Artikel
Sprache:	eng
Schlagworte:	Antioxidants Antioxidants - pharmacology Apoptosis Apoptosis - drug effects Apoptosis - radiation effects Cell Line, Tumor Humans MAP Kinase Signaling System - drug effects MAPK signaling Nasopharyngeal carcinoma Nasopharyngeal Carcinoma - drug therapy Nasopharyngeal Carcinoma - metabolism Nasopharyngeal Carcinoma - radiotherapy Nasopharyngeal Neoplasms - drug therapy Nasopharyngeal Neoplasms - metabolism Nasopharyngeal Neoplasms - radiotherapy Radiation Reactive Oxygen Species - metabolism
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