Differential Effects of Saikosaponins A, B2, B4, C and D on Alcohol and Chocolate Self-Administration in Rats

Differential Effects of Saikosaponins A, B2, B4, C and D on Alcohol and Chocolate Self-Administration in Rats

Abstract Aims Treatment with saikosaponin A (SSA)—an ingredient of the medicinal herb, Bupleurum falcatum—has been reported to suppress several addictive-like behaviors, including morphine, cocaine, alcohol and chocolate self-administration in male rats. The aim of this investigation was to investig...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:Alcohol and alcoholism (Oxford) 2020-06, Vol.55 (4), p.367-373
Hauptverfasser: Maccioni, Paola, Lorrai, Irene, Fara, Federica, Carai, Mauro A M, Gessa, Gian Luigi, Chin, Young-Won, Lee, Jung Hwan, Kwon, Hak Cheol, Corelli, Federico, Colombo, Giancarlo
Format: Artikel
Sprache:eng
Online-Zugang:Volltext
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
container_end_page 373
container_issue 4
container_start_page 367
container_title Alcohol and alcoholism (Oxford)
container_volume 55
creator Maccioni, Paola
Lorrai, Irene
Fara, Federica
Carai, Mauro A M
Gessa, Gian Luigi
Chin, Young-Won
Lee, Jung Hwan
Kwon, Hak Cheol
Corelli, Federico
Colombo, Giancarlo
description Abstract Aims Treatment with saikosaponin A (SSA)—an ingredient of the medicinal herb, Bupleurum falcatum—has been reported to suppress several addictive-like behaviors, including morphine, cocaine, alcohol and chocolate self-administration in male rats. The aim of this investigation was to investigate whether saikosaponins of B. falcatum other than SSA affect alcohol and chocolate self-administration in rats. Methods Ovariectomized female Sardinian alcohol-preferring (sP) and Wistar rats were trained to self-administer alcohol (15%, v/v) and a chocolate solution [5% (w/v) Nesquik® in water], respectively, under fixed ratio schedules of reinforcement. The following saikosaponins were compared to SSA: saikosaponin D (SSD; epimer of SSA), saikosaponin C (SSC), saikosaponin B2 (SSB2) and saikosaponin B4 (SSB4). All saikosaponins were tested acutely at the doses of 0, 0.25, 0.5 and 1 mg/kg (i.p.). Results Treatment with SSA and SSD resulted in highly similar, marked reductions in alcohol self-administration; SSC failed to alter lever-responding for alcohol, while SSB2 and SSB4 produced intermediate reductions. Only SSA and SSD reduced chocolate self-administration, with SSC, SSB2 and SSB4 being ineffective. Conclusions The wide spectrum of efficacy of saikosaponins in reducing alcohol and chocolate self-administration suggests that even relatively small structural differences are sufficient to produce remarkable changes in their in vivo pharmacological profile. Together, these results confirm that roots of B. falcatum may be an interesting source of compounds with anti-addictive potential. Saikosaponins, including saikosaponin A (SSA), are active ingredients of the Asian medicinal herb, Bupleurum falcatum. SSA is known to suppress alcohol, cocaine, morphine and chocolate self-administration in rats. Testing multiple saikosaponins, we found that small structural changes resulted in markedly different effects on alcohol and chocolate self-administration in rats.
doi_str_mv 10.1093/alcalc/agaa049
format Article
fullrecord <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_2406312470</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><oup_id>10.1093/alcalc/agaa049</oup_id><sourcerecordid>2406312470</sourcerecordid><originalsourceid>FETCH-LOGICAL-c2849-521b0d293df10033e035a90db60d247563a0038fcb957e26938bb6181f267a9e3</originalsourceid><addsrcrecordid>eNqFkMtOwzAQRS0EouWxZYm8BKlpx4-kzbK05SFVQqKwjiaJTQ1OHOJ0wd9jSGGL5JFHV2fO4hJywWDMIBUTtEV4E3xFBJkekCGTiYxEDPyQDGEq4ggkkwNy4v0bAJOCs2MyEFxKJiAekmpptFatqjuDlq7CXnSeOk03aN6dx8bVpvZ0PqI3PIwc0QXFuqRL6mo6t4XbOvsTLLaucBY7RTfK6mheVqY2vmuxM4E0NX3Czp-RI43Wq_P9f0peblfPi_to_Xj3sJivo4LPZBrFnOVQ8lSUmgEIoUDEmEKZJyGV0zgRGOKZLvI0niqepGKW5wmbMc2TKaZKnJKr3tu07mOnfJdVxhfKWqyV2_mMS0gECyoI6LhHi9Z53yqdNa2psP3MGGTfFWd9xdm-4nBwuXfv8kqVf_hvpwG47gG3a_6TfQEQAIQj</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2406312470</pqid></control><display><type>article</type><title>Differential Effects of Saikosaponins A, B2, B4, C and D on Alcohol and Chocolate Self-Administration in Rats</title><source>Oxford University Press Journals All Titles (1996-Current)</source><source>Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals</source><source>Alma/SFX Local Collection</source><creator>Maccioni, Paola ; Lorrai, Irene ; Fara, Federica ; Carai, Mauro A M ; Gessa, Gian Luigi ; Chin, Young-Won ; Lee, Jung Hwan ; Kwon, Hak Cheol ; Corelli, Federico ; Colombo, Giancarlo</creator><creatorcontrib>Maccioni, Paola ; Lorrai, Irene ; Fara, Federica ; Carai, Mauro A M ; Gessa, Gian Luigi ; Chin, Young-Won ; Lee, Jung Hwan ; Kwon, Hak Cheol ; Corelli, Federico ; Colombo, Giancarlo</creatorcontrib><description>Abstract Aims Treatment with saikosaponin A (SSA)—an ingredient of the medicinal herb, Bupleurum falcatum—has been reported to suppress several addictive-like behaviors, including morphine, cocaine, alcohol and chocolate self-administration in male rats. The aim of this investigation was to investigate whether saikosaponins of B. falcatum other than SSA affect alcohol and chocolate self-administration in rats. Methods Ovariectomized female Sardinian alcohol-preferring (sP) and Wistar rats were trained to self-administer alcohol (15%, v/v) and a chocolate solution [5% (w/v) Nesquik® in water], respectively, under fixed ratio schedules of reinforcement. The following saikosaponins were compared to SSA: saikosaponin D (SSD; epimer of SSA), saikosaponin C (SSC), saikosaponin B2 (SSB2) and saikosaponin B4 (SSB4). All saikosaponins were tested acutely at the doses of 0, 0.25, 0.5 and 1 mg/kg (i.p.). Results Treatment with SSA and SSD resulted in highly similar, marked reductions in alcohol self-administration; SSC failed to alter lever-responding for alcohol, while SSB2 and SSB4 produced intermediate reductions. Only SSA and SSD reduced chocolate self-administration, with SSC, SSB2 and SSB4 being ineffective. Conclusions The wide spectrum of efficacy of saikosaponins in reducing alcohol and chocolate self-administration suggests that even relatively small structural differences are sufficient to produce remarkable changes in their in vivo pharmacological profile. Together, these results confirm that roots of B. falcatum may be an interesting source of compounds with anti-addictive potential. Saikosaponins, including saikosaponin A (SSA), are active ingredients of the Asian medicinal herb, Bupleurum falcatum. SSA is known to suppress alcohol, cocaine, morphine and chocolate self-administration in rats. Testing multiple saikosaponins, we found that small structural changes resulted in markedly different effects on alcohol and chocolate self-administration in rats.</description><identifier>ISSN: 0735-0414</identifier><identifier>EISSN: 1464-3502</identifier><identifier>DOI: 10.1093/alcalc/agaa049</identifier><identifier>PMID: 32441305</identifier><language>eng</language><publisher>England: Oxford University Press</publisher><ispartof>Alcohol and alcoholism (Oxford), 2020-06, Vol.55 (4), p.367-373</ispartof><rights>The Author(s) 2020. Medical Council on Alcohol and Oxford University Press. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com. 2020</rights><rights>The Author(s) 2020. Medical Council on Alcohol and Oxford University Press. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c2849-521b0d293df10033e035a90db60d247563a0038fcb957e26938bb6181f267a9e3</citedby><cites>FETCH-LOGICAL-c2849-521b0d293df10033e035a90db60d247563a0038fcb957e26938bb6181f267a9e3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,1578,27901,27902</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/32441305$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Maccioni, Paola</creatorcontrib><creatorcontrib>Lorrai, Irene</creatorcontrib><creatorcontrib>Fara, Federica</creatorcontrib><creatorcontrib>Carai, Mauro A M</creatorcontrib><creatorcontrib>Gessa, Gian Luigi</creatorcontrib><creatorcontrib>Chin, Young-Won</creatorcontrib><creatorcontrib>Lee, Jung Hwan</creatorcontrib><creatorcontrib>Kwon, Hak Cheol</creatorcontrib><creatorcontrib>Corelli, Federico</creatorcontrib><creatorcontrib>Colombo, Giancarlo</creatorcontrib><title>Differential Effects of Saikosaponins A, B2, B4, C and D on Alcohol and Chocolate Self-Administration in Rats</title><title>Alcohol and alcoholism (Oxford)</title><addtitle>Alcohol Alcohol</addtitle><description>Abstract Aims Treatment with saikosaponin A (SSA)—an ingredient of the medicinal herb, Bupleurum falcatum—has been reported to suppress several addictive-like behaviors, including morphine, cocaine, alcohol and chocolate self-administration in male rats. The aim of this investigation was to investigate whether saikosaponins of B. falcatum other than SSA affect alcohol and chocolate self-administration in rats. Methods Ovariectomized female Sardinian alcohol-preferring (sP) and Wistar rats were trained to self-administer alcohol (15%, v/v) and a chocolate solution [5% (w/v) Nesquik® in water], respectively, under fixed ratio schedules of reinforcement. The following saikosaponins were compared to SSA: saikosaponin D (SSD; epimer of SSA), saikosaponin C (SSC), saikosaponin B2 (SSB2) and saikosaponin B4 (SSB4). All saikosaponins were tested acutely at the doses of 0, 0.25, 0.5 and 1 mg/kg (i.p.). Results Treatment with SSA and SSD resulted in highly similar, marked reductions in alcohol self-administration; SSC failed to alter lever-responding for alcohol, while SSB2 and SSB4 produced intermediate reductions. Only SSA and SSD reduced chocolate self-administration, with SSC, SSB2 and SSB4 being ineffective. Conclusions The wide spectrum of efficacy of saikosaponins in reducing alcohol and chocolate self-administration suggests that even relatively small structural differences are sufficient to produce remarkable changes in their in vivo pharmacological profile. Together, these results confirm that roots of B. falcatum may be an interesting source of compounds with anti-addictive potential. Saikosaponins, including saikosaponin A (SSA), are active ingredients of the Asian medicinal herb, Bupleurum falcatum. SSA is known to suppress alcohol, cocaine, morphine and chocolate self-administration in rats. Testing multiple saikosaponins, we found that small structural changes resulted in markedly different effects on alcohol and chocolate self-administration in rats.</description><issn>0735-0414</issn><issn>1464-3502</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><recordid>eNqFkMtOwzAQRS0EouWxZYm8BKlpx4-kzbK05SFVQqKwjiaJTQ1OHOJ0wd9jSGGL5JFHV2fO4hJywWDMIBUTtEV4E3xFBJkekCGTiYxEDPyQDGEq4ggkkwNy4v0bAJOCs2MyEFxKJiAekmpptFatqjuDlq7CXnSeOk03aN6dx8bVpvZ0PqI3PIwc0QXFuqRL6mo6t4XbOvsTLLaucBY7RTfK6mheVqY2vmuxM4E0NX3Czp-RI43Wq_P9f0peblfPi_to_Xj3sJivo4LPZBrFnOVQ8lSUmgEIoUDEmEKZJyGV0zgRGOKZLvI0niqepGKW5wmbMc2TKaZKnJKr3tu07mOnfJdVxhfKWqyV2_mMS0gECyoI6LhHi9Z53yqdNa2psP3MGGTfFWd9xdm-4nBwuXfv8kqVf_hvpwG47gG3a_6TfQEQAIQj</recordid><startdate>20200625</startdate><enddate>20200625</enddate><creator>Maccioni, Paola</creator><creator>Lorrai, Irene</creator><creator>Fara, Federica</creator><creator>Carai, Mauro A M</creator><creator>Gessa, Gian Luigi</creator><creator>Chin, Young-Won</creator><creator>Lee, Jung Hwan</creator><creator>Kwon, Hak Cheol</creator><creator>Corelli, Federico</creator><creator>Colombo, Giancarlo</creator><general>Oxford University Press</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20200625</creationdate><title>Differential Effects of Saikosaponins A, B2, B4, C and D on Alcohol and Chocolate Self-Administration in Rats</title><author>Maccioni, Paola ; Lorrai, Irene ; Fara, Federica ; Carai, Mauro A M ; Gessa, Gian Luigi ; Chin, Young-Won ; Lee, Jung Hwan ; Kwon, Hak Cheol ; Corelli, Federico ; Colombo, Giancarlo</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c2849-521b0d293df10033e035a90db60d247563a0038fcb957e26938bb6181f267a9e3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Maccioni, Paola</creatorcontrib><creatorcontrib>Lorrai, Irene</creatorcontrib><creatorcontrib>Fara, Federica</creatorcontrib><creatorcontrib>Carai, Mauro A M</creatorcontrib><creatorcontrib>Gessa, Gian Luigi</creatorcontrib><creatorcontrib>Chin, Young-Won</creatorcontrib><creatorcontrib>Lee, Jung Hwan</creatorcontrib><creatorcontrib>Kwon, Hak Cheol</creatorcontrib><creatorcontrib>Corelli, Federico</creatorcontrib><creatorcontrib>Colombo, Giancarlo</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Alcohol and alcoholism (Oxford)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Maccioni, Paola</au><au>Lorrai, Irene</au><au>Fara, Federica</au><au>Carai, Mauro A M</au><au>Gessa, Gian Luigi</au><au>Chin, Young-Won</au><au>Lee, Jung Hwan</au><au>Kwon, Hak Cheol</au><au>Corelli, Federico</au><au>Colombo, Giancarlo</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Differential Effects of Saikosaponins A, B2, B4, C and D on Alcohol and Chocolate Self-Administration in Rats</atitle><jtitle>Alcohol and alcoholism (Oxford)</jtitle><addtitle>Alcohol Alcohol</addtitle><date>2020-06-25</date><risdate>2020</risdate><volume>55</volume><issue>4</issue><spage>367</spage><epage>373</epage><pages>367-373</pages><issn>0735-0414</issn><eissn>1464-3502</eissn><abstract>Abstract Aims Treatment with saikosaponin A (SSA)—an ingredient of the medicinal herb, Bupleurum falcatum—has been reported to suppress several addictive-like behaviors, including morphine, cocaine, alcohol and chocolate self-administration in male rats. The aim of this investigation was to investigate whether saikosaponins of B. falcatum other than SSA affect alcohol and chocolate self-administration in rats. Methods Ovariectomized female Sardinian alcohol-preferring (sP) and Wistar rats were trained to self-administer alcohol (15%, v/v) and a chocolate solution [5% (w/v) Nesquik® in water], respectively, under fixed ratio schedules of reinforcement. The following saikosaponins were compared to SSA: saikosaponin D (SSD; epimer of SSA), saikosaponin C (SSC), saikosaponin B2 (SSB2) and saikosaponin B4 (SSB4). All saikosaponins were tested acutely at the doses of 0, 0.25, 0.5 and 1 mg/kg (i.p.). Results Treatment with SSA and SSD resulted in highly similar, marked reductions in alcohol self-administration; SSC failed to alter lever-responding for alcohol, while SSB2 and SSB4 produced intermediate reductions. Only SSA and SSD reduced chocolate self-administration, with SSC, SSB2 and SSB4 being ineffective. Conclusions The wide spectrum of efficacy of saikosaponins in reducing alcohol and chocolate self-administration suggests that even relatively small structural differences are sufficient to produce remarkable changes in their in vivo pharmacological profile. Together, these results confirm that roots of B. falcatum may be an interesting source of compounds with anti-addictive potential. Saikosaponins, including saikosaponin A (SSA), are active ingredients of the Asian medicinal herb, Bupleurum falcatum. SSA is known to suppress alcohol, cocaine, morphine and chocolate self-administration in rats. Testing multiple saikosaponins, we found that small structural changes resulted in markedly different effects on alcohol and chocolate self-administration in rats.</abstract><cop>England</cop><pub>Oxford University Press</pub><pmid>32441305</pmid><doi>10.1093/alcalc/agaa049</doi><tpages>7</tpages><oa>free_for_read</oa></addata></record>
fulltext fulltext
identifier ISSN: 0735-0414
ispartof Alcohol and alcoholism (Oxford), 2020-06, Vol.55 (4), p.367-373
issn 0735-0414
1464-3502
language eng
recordid cdi_proquest_miscellaneous_2406312470
source Oxford University Press Journals All Titles (1996-Current); Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; Alma/SFX Local Collection
title Differential Effects of Saikosaponins A, B2, B4, C and D on Alcohol and Chocolate Self-Administration in Rats
url https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-05T15%3A30%3A33IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Differential%20Effects%20of%20Saikosaponins%20A,%20B2,%20B4,%20C%20and%20D%20on%20Alcohol%20and%20Chocolate%20Self-Administration%20in%20Rats&rft.jtitle=Alcohol%20and%20alcoholism%20(Oxford)&rft.au=Maccioni,%20Paola&rft.date=2020-06-25&rft.volume=55&rft.issue=4&rft.spage=367&rft.epage=373&rft.pages=367-373&rft.issn=0735-0414&rft.eissn=1464-3502&rft_id=info:doi/10.1093/alcalc/agaa049&rft_dat=%3Cproquest_cross%3E2406312470%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2406312470&rft_id=info:pmid/32441305&rft_oup_id=10.1093/alcalc/agaa049&rfr_iscdi=true