Investigation on entraining and enhancing human circadian rhythm in closed environments using daylight-like LED mixed lighting
Humans can undergo circadian disruption and misalignment when living in closed environments without sufficient daylight. Therefore, it is of great significance to investigate the effects of artificial light on the circadian rhythm. In this work, the red, green, blue, warm white, and cool white (RGBW...
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| Veröffentlicht in: | The Science of the total environment 2020-08, Vol.732, p.139334-139334, Article 139334 |
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| creator | Nie, Jingxin Zhou, Tianhang Chen, Zhizhong Dang, Weimin Jiao, Fei Zhan, Jinglin Chen, Yifan Chen, Yiyong Pan, Zuojian Kang, Xiangning Wang, Yongzhi Wang, Qi Dong, Wentian Zhou, Shuzhe Yu, Xin Zhang, Guoyi Shen, Bo |
| description | Humans can undergo circadian disruption and misalignment when living in closed environments without sufficient daylight. Therefore, it is of great significance to investigate the effects of artificial light on the circadian rhythm. In this work, the red, green, blue, warm white, and cool white (RGBWW) five-channel light-emitting diodes (LEDs) were fabricated as the only light sources in the closed environment. The LED mixed lighting showed a high color rendering index (CRI) all the time. During the day, the light simulated the daylight and increased the tunability of the circadian action factor (CAF) and correlated color temperature (CCT). At night, it maintained low CAF and CCT. Three subjects did irregular shift work in the closed environment for 38 days. Their plasma melatonin and daily activity were measured to assess the circadian rhythm. After 38 days, the subjects' peak melatonin times did not shift significantly (p = 0.676), while their peak melatonin concentrations increased apparently (p = 0.005). The start times of the least active 5-h period (L5) in one day fluctuated in a small range. The standard deviation (SD) was |
| doi_str_mv | 10.1016/j.scitotenv.2020.139334 |
| format | Article |
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[Display omitted]
•We built up daylight-like environment with increasing tunability CAF and CCT.•Closed light environment entrained the circadian rhythms of subjects for 38 days.•The rhythm enhanced with significantly increased peak melatonin concentration.•The circular cross-correlation indicated the entrainment of light on the rhythm.</description><identifier>ISSN: 0048-9697</identifier><identifier>EISSN: 1879-1026</identifier><identifier>DOI: 10.1016/j.scitotenv.2020.139334</identifier><identifier>PMID: 32438188</identifier><language>eng</language><publisher>Netherlands: Elsevier B.V</publisher><subject>Activity ; Circadian action factor ; Circadian rhythm ; Light-emitting diode ; Melatonin</subject><ispartof>The Science of the total environment, 2020-08, Vol.732, p.139334-139334, Article 139334</ispartof><rights>2020 Elsevier B.V.</rights><rights>Copyright © 2020. Published by Elsevier B.V.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c371t-be3cc2f4439621bae5eac307921347cfb3db9e27209e8720012e0345deb1d7523</citedby><cites>FETCH-LOGICAL-c371t-be3cc2f4439621bae5eac307921347cfb3db9e27209e8720012e0345deb1d7523</cites><orcidid>0000-0001-7979-8497</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.scitotenv.2020.139334$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3548,27923,27924,45994</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/32438188$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Nie, Jingxin</creatorcontrib><creatorcontrib>Zhou, Tianhang</creatorcontrib><creatorcontrib>Chen, Zhizhong</creatorcontrib><creatorcontrib>Dang, Weimin</creatorcontrib><creatorcontrib>Jiao, Fei</creatorcontrib><creatorcontrib>Zhan, Jinglin</creatorcontrib><creatorcontrib>Chen, Yifan</creatorcontrib><creatorcontrib>Chen, Yiyong</creatorcontrib><creatorcontrib>Pan, Zuojian</creatorcontrib><creatorcontrib>Kang, Xiangning</creatorcontrib><creatorcontrib>Wang, Yongzhi</creatorcontrib><creatorcontrib>Wang, Qi</creatorcontrib><creatorcontrib>Dong, Wentian</creatorcontrib><creatorcontrib>Zhou, Shuzhe</creatorcontrib><creatorcontrib>Yu, Xin</creatorcontrib><creatorcontrib>Zhang, Guoyi</creatorcontrib><creatorcontrib>Shen, Bo</creatorcontrib><title>Investigation on entraining and enhancing human circadian rhythm in closed environments using daylight-like LED mixed lighting</title><title>The Science of the total environment</title><addtitle>Sci Total Environ</addtitle><description>Humans can undergo circadian disruption and misalignment when living in closed environments without sufficient daylight. Therefore, it is of great significance to investigate the effects of artificial light on the circadian rhythm. In this work, the red, green, blue, warm white, and cool white (RGBWW) five-channel light-emitting diodes (LEDs) were fabricated as the only light sources in the closed environment. The LED mixed lighting showed a high color rendering index (CRI) all the time. During the day, the light simulated the daylight and increased the tunability of the circadian action factor (CAF) and correlated color temperature (CCT). At night, it maintained low CAF and CCT. Three subjects did irregular shift work in the closed environment for 38 days. Their plasma melatonin and daily activity were measured to assess the circadian rhythm. After 38 days, the subjects' peak melatonin times did not shift significantly (p = 0.676), while their peak melatonin concentrations increased apparently (p = 0.005). The start times of the least active 5-h period (L5) in one day fluctuated in a small range. The standard deviation (SD) was <15.11 min in most times. These results demonstrated that the subjects' rhythms maintained stable and were enhanced. The periods of circular cross-correlation between activity and CAF oscillated around 24 h (SD = 15.4 min), indicating the entrainment of light on the stable 24-h rhythm. It was concluded that the daylight-like LED lighting effectively entrained and enhanced the circadian rhythm in the closed environment.
[Display omitted]
•We built up daylight-like environment with increasing tunability CAF and CCT.•Closed light environment entrained the circadian rhythms of subjects for 38 days.•The rhythm enhanced with significantly increased peak melatonin concentration.•The circular cross-correlation indicated the entrainment of light on the rhythm.</description><subject>Activity</subject><subject>Circadian action factor</subject><subject>Circadian rhythm</subject><subject>Light-emitting diode</subject><subject>Melatonin</subject><issn>0048-9697</issn><issn>1879-1026</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><recordid>eNqFkE1v2zAMhoWhxZq2-wubj70404dj2ccgy9YAAXZpz4IsMTEzW84kOVgu_e2Tm67XCYIoEs9Lgi8hXxidM8rKr4d5MBiHCO4055SnqqiFKD6QGatknTPKyysyo7So8rqs5Q25DeFA05EV-0huBC9ExapqRl427gQh4l5HHFyWLrjoNTp0-0w7m9JWOzNl7dhrlxn0RltMP9-eY9tnmGrdEGBCT-gH16cOIRvDpLH63OG-jXmHvyDbrr9lPf5J6GsxAffkeqe7AJ_e4h15_r5-Wj3m258_NqvlNjdCspg3IIzhu6IQdclZo2EB2ggqa85EIc2uEbapgUtOa6jSSxkHKoqFhYZZueDijjxc-h798HtMC6seg4Gu0w6GMShe0FIwtpATKi-o8UMIHnbq6LHX_qwYVZP56qDezVeT-epiflJ-fhsyNj3Yd90_txOwvACQVj0h-KkROAMWPZio7ID_HfIXi5GckQ</recordid><startdate>20200825</startdate><enddate>20200825</enddate><creator>Nie, Jingxin</creator><creator>Zhou, Tianhang</creator><creator>Chen, Zhizhong</creator><creator>Dang, Weimin</creator><creator>Jiao, Fei</creator><creator>Zhan, Jinglin</creator><creator>Chen, Yifan</creator><creator>Chen, Yiyong</creator><creator>Pan, Zuojian</creator><creator>Kang, Xiangning</creator><creator>Wang, Yongzhi</creator><creator>Wang, Qi</creator><creator>Dong, Wentian</creator><creator>Zhou, Shuzhe</creator><creator>Yu, Xin</creator><creator>Zhang, Guoyi</creator><creator>Shen, Bo</creator><general>Elsevier B.V</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0001-7979-8497</orcidid></search><sort><creationdate>20200825</creationdate><title>Investigation on entraining and enhancing human circadian rhythm in closed environments using daylight-like LED mixed lighting</title><author>Nie, Jingxin ; Zhou, Tianhang ; Chen, Zhizhong ; Dang, Weimin ; Jiao, Fei ; Zhan, Jinglin ; Chen, Yifan ; Chen, Yiyong ; Pan, Zuojian ; Kang, Xiangning ; Wang, Yongzhi ; Wang, Qi ; Dong, Wentian ; Zhou, Shuzhe ; Yu, Xin ; Zhang, Guoyi ; Shen, Bo</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c371t-be3cc2f4439621bae5eac307921347cfb3db9e27209e8720012e0345deb1d7523</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><topic>Activity</topic><topic>Circadian action factor</topic><topic>Circadian rhythm</topic><topic>Light-emitting diode</topic><topic>Melatonin</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Nie, Jingxin</creatorcontrib><creatorcontrib>Zhou, Tianhang</creatorcontrib><creatorcontrib>Chen, Zhizhong</creatorcontrib><creatorcontrib>Dang, Weimin</creatorcontrib><creatorcontrib>Jiao, Fei</creatorcontrib><creatorcontrib>Zhan, Jinglin</creatorcontrib><creatorcontrib>Chen, Yifan</creatorcontrib><creatorcontrib>Chen, Yiyong</creatorcontrib><creatorcontrib>Pan, Zuojian</creatorcontrib><creatorcontrib>Kang, Xiangning</creatorcontrib><creatorcontrib>Wang, Yongzhi</creatorcontrib><creatorcontrib>Wang, Qi</creatorcontrib><creatorcontrib>Dong, Wentian</creatorcontrib><creatorcontrib>Zhou, Shuzhe</creatorcontrib><creatorcontrib>Yu, Xin</creatorcontrib><creatorcontrib>Zhang, Guoyi</creatorcontrib><creatorcontrib>Shen, Bo</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>The Science of the total environment</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Nie, Jingxin</au><au>Zhou, Tianhang</au><au>Chen, Zhizhong</au><au>Dang, Weimin</au><au>Jiao, Fei</au><au>Zhan, Jinglin</au><au>Chen, Yifan</au><au>Chen, Yiyong</au><au>Pan, Zuojian</au><au>Kang, Xiangning</au><au>Wang, Yongzhi</au><au>Wang, Qi</au><au>Dong, Wentian</au><au>Zhou, Shuzhe</au><au>Yu, Xin</au><au>Zhang, Guoyi</au><au>Shen, Bo</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Investigation on entraining and enhancing human circadian rhythm in closed environments using daylight-like LED mixed lighting</atitle><jtitle>The Science of the total environment</jtitle><addtitle>Sci Total Environ</addtitle><date>2020-08-25</date><risdate>2020</risdate><volume>732</volume><spage>139334</spage><epage>139334</epage><pages>139334-139334</pages><artnum>139334</artnum><issn>0048-9697</issn><eissn>1879-1026</eissn><abstract>Humans can undergo circadian disruption and misalignment when living in closed environments without sufficient daylight. Therefore, it is of great significance to investigate the effects of artificial light on the circadian rhythm. In this work, the red, green, blue, warm white, and cool white (RGBWW) five-channel light-emitting diodes (LEDs) were fabricated as the only light sources in the closed environment. The LED mixed lighting showed a high color rendering index (CRI) all the time. During the day, the light simulated the daylight and increased the tunability of the circadian action factor (CAF) and correlated color temperature (CCT). At night, it maintained low CAF and CCT. Three subjects did irregular shift work in the closed environment for 38 days. Their plasma melatonin and daily activity were measured to assess the circadian rhythm. After 38 days, the subjects' peak melatonin times did not shift significantly (p = 0.676), while their peak melatonin concentrations increased apparently (p = 0.005). The start times of the least active 5-h period (L5) in one day fluctuated in a small range. The standard deviation (SD) was <15.11 min in most times. These results demonstrated that the subjects' rhythms maintained stable and were enhanced. The periods of circular cross-correlation between activity and CAF oscillated around 24 h (SD = 15.4 min), indicating the entrainment of light on the stable 24-h rhythm. It was concluded that the daylight-like LED lighting effectively entrained and enhanced the circadian rhythm in the closed environment.
[Display omitted]
•We built up daylight-like environment with increasing tunability CAF and CCT.•Closed light environment entrained the circadian rhythms of subjects for 38 days.•The rhythm enhanced with significantly increased peak melatonin concentration.•The circular cross-correlation indicated the entrainment of light on the rhythm.</abstract><cop>Netherlands</cop><pub>Elsevier B.V</pub><pmid>32438188</pmid><doi>10.1016/j.scitotenv.2020.139334</doi><tpages>1</tpages><orcidid>https://orcid.org/0000-0001-7979-8497</orcidid></addata></record> |
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| subjects | Activity Circadian action factor Circadian rhythm Light-emitting diode Melatonin |
| title | Investigation on entraining and enhancing human circadian rhythm in closed environments using daylight-like LED mixed lighting |
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