The circular RNA TLK1 exacerbates myocardial ischemia/reperfusion injury via targeting miR-214/RIPK1 through TNF signaling pathway

Myocardial ischemia/reperfusion injury (IRI) induces cardiomyocytes death and leads to loss of cardiac function. Circular RNAs (circRNA) have gain increasing interests in modulating myocardial IRI. In this study, we aim to investigate the role and exact mechanism of circTLK1 in the pathogenesis of m...

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Veröffentlicht in:	Free radical biology & medicine 2020-08, Vol.155, p.69-80
Hauptverfasser:	Song, Yu-Fang, Zhao, Liang, Wang, Bao-Cai, Sun, Jun-Jie, Hu, Jun-Long, Zhu, Xi-Liang, Zhao, Jian, Zheng, Dao-Kuo, Ge, Zhen-Wei
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Apoptosis CircTLK1 Disease Models, Animal Mice MicroRNAs - genetics miR-214 Myocardial ischemia/reperfusion Myocardial Reperfusion Injury - genetics Myocytes, Cardiac Receptor-Interacting Protein Serine-Threonine Kinases Reperfusion Injury - genetics RNA, Circular Signal Transduction TNF-α signaling
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