Methanol-Essential Growth of Corynebacterium glutamicum : Adaptive Laboratory Evolution Overcomes Limitation due to Methanethiol Assimilation Pathway

Methanol is a sustainable substrate for biotechnology. In addition to natural methylotrophs, metabolic engineering has gained attention for transfer of methylotrophy. Here, we engineered for methanol-dependent growth with a sugar co-substrate. Heterologous expression of genes for methanol dehydrogen...

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Veröffentlicht in:	International journal of molecular sciences 2020-05, Vol.21 (10), p.3617
Hauptverfasser:	Hennig, Guido, Haupka, Carsten, Brito, Luciana F, Rückert, Christian, Cahoreau, Edern, Heux, Stéphanie, Wendisch, Volker F
Format:	Artikel
Sprache:	eng
Schlagworte:	Alcohol Oxidoreductases - genetics Alcohol Oxidoreductases - metabolism Aldehyde-Lyases - genetics Aldehyde-Lyases - metabolism Aldose-Ketose Isomerases - genetics Aldose-Ketose Isomerases - metabolism Bacillus subtilis - genetics Bacterial Proteins - genetics Bacterial Proteins - metabolism Biochemistry, Molecular Biology Chemical Sciences Corynebacterium glutamicum - genetics Corynebacterium glutamicum - metabolism Directed Molecular Evolution - methods Industrial Microbiology - methods Life Sciences Metabolic Engineering - methods Methanol - metabolism Riboflavin - metabolism Ribulosephosphates - metabolism Sulfhydryl Compounds - metabolism Transgenes
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