Antiproliferative activity of side-chain truncated vitamin D analogs (PRI-1203 and PRI-1204) against human malignant melanoma cell lines

Vitamin D compounds are versatile molecules widely considered as promising agents in cancer prevention and treatment, including melanoma. Previously we investigated series of double point modified vitamin D2 analogs as well as non-calcemic 20S-hydroxyvitamin D3 and 21-hydroxypregnacalciferol as to t...

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Veröffentlicht in:	European journal of pharmacology 2020-08, Vol.881, p.173170-173170, Article 173170
Hauptverfasser:	Piotrowska, Anna, Wierzbicka, Justyna, Kwiatkowska, Kamila, Chodyński, Michał, Kutner, Andrzej, Żmijewski, Michał A.
Format:	Artikel
Sprache:	eng
Schlagworte:	Active Transport, Cell Nucleus Antineoplastic Agents - chemistry Antineoplastic Agents - pharmacology Calcitriol - analogs & derivatives Calcitriol - chemistry Calcitriol - pharmacology Cell Cycle Checkpoints - drug effects Cell Line, Tumor Cell Movement - drug effects Cell Proliferation - drug effects Enzyme Induction Gene Expression Regulation, Neoplastic Humans Isomerism Melanoma Melanoma - drug therapy Melanoma - genetics Melanoma - metabolism Melanoma - pathology Neoplasm Invasiveness Pregnacalciferol PRI-1203 PRI-1204 Receptors, Calcitriol - agonists Receptors, Calcitriol - metabolism Side-chain truncated vitamin D analogs Skin Neoplasms - drug therapy Skin Neoplasms - genetics Skin Neoplasms - metabolism Skin Neoplasms - pathology Structure-Activity Relationship Vitamin D Vitamin D3 24-Hydroxylase - biosynthesis Vitamin D3 24-Hydroxylase - genetics
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