Chronic hM3Dq signaling in microglia ameliorates neuroinflammation in male mice

•Mouse line generated to express hM3Dq selectively in microglia.•Microglial function was manipulated by specific activation of hM3Dq signaling.•Acute microglial hM3Dq signaling modulated expression of pro-inflammatory cytokines.•Chronic activation of hM3Dq increased tolerance to LPS-mediated cytokin...

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Veröffentlicht in:	Brain, behavior, and immunity behavior, and immunity, 2020-08, Vol.88, p.791-801
Hauptverfasser:	Binning, William, Hogan-Cann, Aja E., Yae Sakae, Diana, Maksoud, Matthew, Ostapchenko, Valeriy, Al-Onaizi, Mohammed, Matovic, Sara, Lu, Wei-Yang, Prado, Marco A.M., Inoue, Wataru, Prado, Vania F.
Format:	Artikel
Sprache:	eng
Schlagworte:	Acetylcholine Animals Clozapine - pharmacology Cytokine DREADD GPCR Male Mice Microglia Muscarinic receptor Neurons Receptors, G-Protein-Coupled Sickness behavior Signal Transduction
Online-Zugang:	Volltext
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