EBV and CMV viral load in rheumatoid arthritis and their role in associated Sjögren's syndrome
Introduction The role of viral infections in the pathogenesis of autoimmune diseases has long been suggested, but little evidence is available. Objective This study aimed to evaluate an association between EBV and CMV and the presence of rheumatoid arthritis and its association with Sjögren's S...
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| Veröffentlicht in: | Journal of oral pathology & medicine 2020-08, Vol.49 (7), p.693-700 |
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| creator | Sorgato, Camila Carvalho Lins‐e‐Silva, Marília Leão, Jair Carneiro Vasconcelos, Luydson Richardson Romão, Tatiany Patrícia Duarte, Angela Luzia Gueiros, Luiz Alcino |
| description | Introduction
The role of viral infections in the pathogenesis of autoimmune diseases has long been suggested, but little evidence is available.
Objective
This study aimed to evaluate an association between EBV and CMV and the presence of rheumatoid arthritis and its association with Sjögren's Syndrome.
Patients and Method
A case‐control study was performed with 227 patients divided in RA (n = 99), RA/SS (n = 20), and C (n = 128). Resting salivary flow rate and Schirmer's test were performed; minor salivary gland biopsy was indicated in the case of suspected Sjögren's syndrome. CMV and EBV viral loads were quantified in peripheral blood, and their presence in glandular tissue samples was evaluated by in situ hybridization (EBV) and immunohistochemistry (CMV).
Results
EBV was more frequent in RA and RA/SS than in C (P .05) or between RA and RA/SS was found (P > .05). A higher number of EBV/DNA copies were found in RA (158.52 copies/μL) and RA/SS (99.24 copies/μL) (P = .739). EBV/DNA was associated with the Schirmer test (P = .0231). CMV was detected in one patient of the RA group. None of the viruses were detected in biopsies of minor salivary glands.
Conclusions
Detection of EBV/DNA in peripheral blood was associated with RA regardless of the presence of SS. |
| doi_str_mv | 10.1111/jop.13036 |
| format | Article |
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The role of viral infections in the pathogenesis of autoimmune diseases has long been suggested, but little evidence is available.
Objective
This study aimed to evaluate an association between EBV and CMV and the presence of rheumatoid arthritis and its association with Sjögren's Syndrome.
Patients and Method
A case‐control study was performed with 227 patients divided in RA (n = 99), RA/SS (n = 20), and C (n = 128). Resting salivary flow rate and Schirmer's test were performed; minor salivary gland biopsy was indicated in the case of suspected Sjögren's syndrome. CMV and EBV viral loads were quantified in peripheral blood, and their presence in glandular tissue samples was evaluated by in situ hybridization (EBV) and immunohistochemistry (CMV).
Results
EBV was more frequent in RA and RA/SS than in C (P < .000007). No correlation with clinical markers (P > .05) or between RA and RA/SS was found (P > .05). A higher number of EBV/DNA copies were found in RA (158.52 copies/μL) and RA/SS (99.24 copies/μL) (P = .739). EBV/DNA was associated with the Schirmer test (P = .0231). CMV was detected in one patient of the RA group. None of the viruses were detected in biopsies of minor salivary glands.
Conclusions
Detection of EBV/DNA in peripheral blood was associated with RA regardless of the presence of SS.</description><identifier>ISSN: 0904-2512</identifier><identifier>EISSN: 1600-0714</identifier><identifier>DOI: 10.1111/jop.13036</identifier><identifier>PMID: 32428250</identifier><language>eng</language><publisher>Denmark: Wiley Subscription Services, Inc</publisher><subject>Autoimmune diseases ; Biopsy ; cytomegalovirus ; Dentistry ; Deoxyribonucleic acid ; DNA ; Epstein‐Barr Virus Infections ; Hybridization ; Immunohistochemistry ; Peripheral blood ; Rheumatoid arthritis ; Salivary gland ; Sjogren's syndrome ; Sjögren's syndrome</subject><ispartof>Journal of oral pathology & medicine, 2020-08, Vol.49 (7), p.693-700</ispartof><rights>2020 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd</rights><rights>This article is protected by copyright. All rights reserved.</rights><rights>Copyright © 2020 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3536-a83eff8dc307bd9ef917a9f6d011bf0eeae8eec93cb5d104151253656b7995793</citedby><cites>FETCH-LOGICAL-c3536-a83eff8dc307bd9ef917a9f6d011bf0eeae8eec93cb5d104151253656b7995793</cites><orcidid>0000-0003-4979-4318 ; 0000-0001-8303-2291</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fjop.13036$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fjop.13036$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,780,784,1417,27924,27925,45574,45575</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/32428250$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Sorgato, Camila Carvalho</creatorcontrib><creatorcontrib>Lins‐e‐Silva, Marília</creatorcontrib><creatorcontrib>Leão, Jair Carneiro</creatorcontrib><creatorcontrib>Vasconcelos, Luydson Richardson</creatorcontrib><creatorcontrib>Romão, Tatiany Patrícia</creatorcontrib><creatorcontrib>Duarte, Angela Luzia</creatorcontrib><creatorcontrib>Gueiros, Luiz Alcino</creatorcontrib><title>EBV and CMV viral load in rheumatoid arthritis and their role in associated Sjögren's syndrome</title><title>Journal of oral pathology & medicine</title><addtitle>J Oral Pathol Med</addtitle><description>Introduction
The role of viral infections in the pathogenesis of autoimmune diseases has long been suggested, but little evidence is available.
Objective
This study aimed to evaluate an association between EBV and CMV and the presence of rheumatoid arthritis and its association with Sjögren's Syndrome.
Patients and Method
A case‐control study was performed with 227 patients divided in RA (n = 99), RA/SS (n = 20), and C (n = 128). Resting salivary flow rate and Schirmer's test were performed; minor salivary gland biopsy was indicated in the case of suspected Sjögren's syndrome. CMV and EBV viral loads were quantified in peripheral blood, and their presence in glandular tissue samples was evaluated by in situ hybridization (EBV) and immunohistochemistry (CMV).
Results
EBV was more frequent in RA and RA/SS than in C (P < .000007). No correlation with clinical markers (P > .05) or between RA and RA/SS was found (P > .05). A higher number of EBV/DNA copies were found in RA (158.52 copies/μL) and RA/SS (99.24 copies/μL) (P = .739). EBV/DNA was associated with the Schirmer test (P = .0231). CMV was detected in one patient of the RA group. None of the viruses were detected in biopsies of minor salivary glands.
Conclusions
Detection of EBV/DNA in peripheral blood was associated with RA regardless of the presence of SS.</description><subject>Autoimmune diseases</subject><subject>Biopsy</subject><subject>cytomegalovirus</subject><subject>Dentistry</subject><subject>Deoxyribonucleic acid</subject><subject>DNA</subject><subject>Epstein‐Barr Virus Infections</subject><subject>Hybridization</subject><subject>Immunohistochemistry</subject><subject>Peripheral blood</subject><subject>Rheumatoid arthritis</subject><subject>Salivary gland</subject><subject>Sjogren's syndrome</subject><subject>Sjögren's syndrome</subject><issn>0904-2512</issn><issn>1600-0714</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><recordid>eNp10EtOwzAQBmALgWgpLLgAssQCWATs2M5jCVV5CVQkoNvIiSfUVRIXOwH1YlyAi-G2wAIJb2bzza_xj9A-JafUv7OZmZ9SRli0gfo0IiQgMeWbqE9SwoNQ0LCHdpybEUJjxuk26rGQh0koSB9lo4sJlo3Cw_sJftNWVrgyUmHdYDuFrpat0QpL206tbrVb0XYK2mJrKlgy6ZwptGxB4cfZ58eLhebIYbdolDU17KKtUlYO9r7nAD1fjp6G18Hd-OpmeH4XFEywKJAJg7JMVMFInKsUypTGMi0jRSjNSwIgIQEoUlbkQlHCqf-U3xNRHqepiFM2QMfr3Lk1rx24Nqu1K6CqZAOmc1nIifDZkeCeHv6hM9PZxl_nFQuThHMReXWyVoU1zlkos7nVtbSLjJJs2brfmmer1r09-E7s8hrUr_yp2YOzNXjXFSz-T8puxw_ryC-wB4s9</recordid><startdate>202008</startdate><enddate>202008</enddate><creator>Sorgato, Camila Carvalho</creator><creator>Lins‐e‐Silva, Marília</creator><creator>Leão, Jair Carneiro</creator><creator>Vasconcelos, Luydson Richardson</creator><creator>Romão, Tatiany Patrícia</creator><creator>Duarte, Angela Luzia</creator><creator>Gueiros, Luiz Alcino</creator><general>Wiley Subscription Services, Inc</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QP</scope><scope>7T5</scope><scope>H94</scope><scope>K9.</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0003-4979-4318</orcidid><orcidid>https://orcid.org/0000-0001-8303-2291</orcidid></search><sort><creationdate>202008</creationdate><title>EBV and CMV viral load in rheumatoid arthritis and their role in associated Sjögren's syndrome</title><author>Sorgato, Camila Carvalho ; Lins‐e‐Silva, Marília ; Leão, Jair Carneiro ; Vasconcelos, Luydson Richardson ; Romão, Tatiany Patrícia ; Duarte, Angela Luzia ; Gueiros, Luiz Alcino</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3536-a83eff8dc307bd9ef917a9f6d011bf0eeae8eec93cb5d104151253656b7995793</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><topic>Autoimmune diseases</topic><topic>Biopsy</topic><topic>cytomegalovirus</topic><topic>Dentistry</topic><topic>Deoxyribonucleic acid</topic><topic>DNA</topic><topic>Epstein‐Barr Virus Infections</topic><topic>Hybridization</topic><topic>Immunohistochemistry</topic><topic>Peripheral blood</topic><topic>Rheumatoid arthritis</topic><topic>Salivary gland</topic><topic>Sjogren's syndrome</topic><topic>Sjögren's syndrome</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Sorgato, Camila Carvalho</creatorcontrib><creatorcontrib>Lins‐e‐Silva, Marília</creatorcontrib><creatorcontrib>Leão, Jair Carneiro</creatorcontrib><creatorcontrib>Vasconcelos, Luydson Richardson</creatorcontrib><creatorcontrib>Romão, Tatiany Patrícia</creatorcontrib><creatorcontrib>Duarte, Angela Luzia</creatorcontrib><creatorcontrib>Gueiros, Luiz Alcino</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Immunology Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of oral pathology & medicine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Sorgato, Camila Carvalho</au><au>Lins‐e‐Silva, Marília</au><au>Leão, Jair Carneiro</au><au>Vasconcelos, Luydson Richardson</au><au>Romão, Tatiany Patrícia</au><au>Duarte, Angela Luzia</au><au>Gueiros, Luiz Alcino</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>EBV and CMV viral load in rheumatoid arthritis and their role in associated Sjögren's syndrome</atitle><jtitle>Journal of oral pathology & medicine</jtitle><addtitle>J Oral Pathol Med</addtitle><date>2020-08</date><risdate>2020</risdate><volume>49</volume><issue>7</issue><spage>693</spage><epage>700</epage><pages>693-700</pages><issn>0904-2512</issn><eissn>1600-0714</eissn><abstract>Introduction
The role of viral infections in the pathogenesis of autoimmune diseases has long been suggested, but little evidence is available.
Objective
This study aimed to evaluate an association between EBV and CMV and the presence of rheumatoid arthritis and its association with Sjögren's Syndrome.
Patients and Method
A case‐control study was performed with 227 patients divided in RA (n = 99), RA/SS (n = 20), and C (n = 128). Resting salivary flow rate and Schirmer's test were performed; minor salivary gland biopsy was indicated in the case of suspected Sjögren's syndrome. CMV and EBV viral loads were quantified in peripheral blood, and their presence in glandular tissue samples was evaluated by in situ hybridization (EBV) and immunohistochemistry (CMV).
Results
EBV was more frequent in RA and RA/SS than in C (P < .000007). No correlation with clinical markers (P > .05) or between RA and RA/SS was found (P > .05). A higher number of EBV/DNA copies were found in RA (158.52 copies/μL) and RA/SS (99.24 copies/μL) (P = .739). EBV/DNA was associated with the Schirmer test (P = .0231). CMV was detected in one patient of the RA group. None of the viruses were detected in biopsies of minor salivary glands.
Conclusions
Detection of EBV/DNA in peripheral blood was associated with RA regardless of the presence of SS.</abstract><cop>Denmark</cop><pub>Wiley Subscription Services, Inc</pub><pmid>32428250</pmid><doi>10.1111/jop.13036</doi><tpages>8</tpages><orcidid>https://orcid.org/0000-0003-4979-4318</orcidid><orcidid>https://orcid.org/0000-0001-8303-2291</orcidid></addata></record> |
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| ispartof | Journal of oral pathology & medicine, 2020-08, Vol.49 (7), p.693-700 |
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| subjects | Autoimmune diseases Biopsy cytomegalovirus Dentistry Deoxyribonucleic acid DNA Epstein‐Barr Virus Infections Hybridization Immunohistochemistry Peripheral blood Rheumatoid arthritis Salivary gland Sjogren's syndrome Sjögren's syndrome |
| title | EBV and CMV viral load in rheumatoid arthritis and their role in associated Sjögren's syndrome |
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