Genomic Epidemiology of Invasive Methicillin-Resistant Staphylococcus aureus Infections Among Hospitalized Individuals in Ontario, Canada

Abstract Background Prevention and control of methicillin-resistant Staphylococcus aureus (MRSA) infections remain challenging. In-depth surveillance integrating patient and isolate data can provide evidence to better inform infection control and public health practice. Methods We analyzed MRSA case...

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Veröffentlicht in:	The Journal of infectious diseases 2020-12, Vol.222 (12), p.2071-2081
Hauptverfasser:	Guthrie, Jennifer L, Teatero, Sarah, Hirai, Sotaro, Fortuna, Alex, Rosen, Daniel, Mallo, Gustavo V, Campbell, Jennifer, Pelude, Linda, Golding, George, Simor, Andrew E, Patel, Samir N, McGeer, Allison, Fittipaldi, Nahuel
Format:	Artikel
Sprache:	eng
Schlagworte:	Adolescent Adult Anti-Bacterial Agents - pharmacology Antibiotics Antimicrobial agents Antimicrobial resistance Child Child, Preschool Clindamycin Drug resistance Drug Resistance, Bacterial - genetics Epidemiology Erythromycin Female Fusidic acid Genetic diversity Genomes Genotype Genotyping Hospitalization - statistics & numerical data Humans Infant Male Methicillin Methicillin-Resistant Staphylococcus aureus - genetics Methicillin-Resistant Staphylococcus aureus - isolation & purification Microbial Sensitivity Tests Middle Aged Molecular Epidemiology Multilocus Sequence Typing Ontario - epidemiology Population structure Public health Sentinel Surveillance Staphylococcal Infections - epidemiology Staphylococcus aureus Staphylococcus infections Whole Genome Sequencing Young Adult
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Zusammenfassung:	Abstract Background Prevention and control of methicillin-resistant Staphylococcus aureus (MRSA) infections remain challenging. In-depth surveillance integrating patient and isolate data can provide evidence to better inform infection control and public health practice. Methods We analyzed MRSA cases diagnosed in 2010 (n = 212) and 2016 (n = 214) by hospitals in Ontario, Canada. Case-level clinical and demographic data were integrated with isolate characteristics, including antimicrobial resistance (AMR), classic genotyping, and whole-genome sequencing results. Results Community-associated MRSA (epidemiologically defined) increased significantly from 23.6% in 2010 to 43.0% in 2016 (P
ISSN:	0022-1899 1537-6613
DOI:	10.1093/infdis/jiaa147