Lupeol suppresses plasminogen activator inhibitor-1-mediated macrophage recruitment and attenuates M2 macrophage polarization

Tumor-associated macrophages (TAMs) are closely related with poor prognosis of cancers. The current study investigated whether lupeol regulates TAMs by focusing on the recruitment and polarization of macrophages. We found that lupeol suppressed the recruitment of THP-1 macrophages (THP-1 cells diffe...

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Veröffentlicht in:	Biochemical and biophysical research communications 2020-07, Vol.527 (4), p.889-895
Hauptverfasser:	Park, Hyun-Ji, Chi, Gyoo-Yong, Choi, Yung-Hyun, Park, Shin-Hyung
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Anti-Inflammatory Agents - pharmacology Cell Line Cell Line, Tumor Cell Movement - drug effects Humans Lung Neoplasms - immunology Lupeol M2 polarization Macrophage Activation - drug effects Mice Pentacyclic Triterpenes - pharmacology Plasminogen Activator Inhibitor 1 - immunology Plasminogen activator inhibitor-1 RAW 264.7 Cells Tumor microenvironment Tumor-associated macrophage Tumor-Associated Macrophages - drug effects Tumor-Associated Macrophages - immunology
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