Ziziphus jujube ameliorated cavernosal oxidative stress and fibrotic processes in cavernous nerve injury‐induced erectile dysfunction in a rat model
The aim of this study was to investigate potential antioxidant and antifibrotic effects of Ziziphus jujube (ZJ) in a cavernosal nerve injury (CNI)‐induced erectile dysfunction (ED) rat model. Forty‐eight male rats were assigned to six‐sized groups as group 1: sham‐operated; group 2: sham‐operated + ...
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| Veröffentlicht in: | Andrologia 2020-08, Vol.52 (7), p.e13632-n/a |
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| creator | Resim, Sefa Koluş, Eyüp Barut, Osman Kucukdurmaz, Faruk Bahar, Abdulkadir Yasir Dagli, Hasan |
| description | The aim of this study was to investigate potential antioxidant and antifibrotic effects of Ziziphus jujube (ZJ) in a cavernosal nerve injury (CNI)‐induced erectile dysfunction (ED) rat model. Forty‐eight male rats were assigned to six‐sized groups as group 1: sham‐operated; group 2: sham‐operated + low‐dose ZJ (200 mg/kg); group 3: sham‐operated + high‐dose ZJ (400 mg/kg); group 4: CNI + distilled water; group 5: CNI + low‐dose ZJ; and group 6: CNI + high‐dose ZJ. At the end of 2 weeks, intracardiac blood was taken and rats were sacrificed. For biochemical analysis, cavernosal transforming growth factor‐beta‐1, collagen type I and type 3, fibronectin, α and β actin were examined in plasma and cavernosa. Superoxide dismutase (SOD), catalase (CAT), malondialdehyde (MDA) and prolidase levels were measured in serum to evaluate antioxidant effect of ZJ. Histopathological examination of tissues revealed that highest fibrosis rate was in group 4 (66.84%). Collagen 1 and 3, alpha and beta actin, fibronectin levels were significantly different among groups (p |
| doi_str_mv | 10.1111/and.13632 |
| format | Article |
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Forty‐eight male rats were assigned to six‐sized groups as group 1: sham‐operated; group 2: sham‐operated + low‐dose ZJ (200 mg/kg); group 3: sham‐operated + high‐dose ZJ (400 mg/kg); group 4: CNI + distilled water; group 5: CNI + low‐dose ZJ; and group 6: CNI + high‐dose ZJ. At the end of 2 weeks, intracardiac blood was taken and rats were sacrificed. For biochemical analysis, cavernosal transforming growth factor‐beta‐1, collagen type I and type 3, fibronectin, α and β actin were examined in plasma and cavernosa. Superoxide dismutase (SOD), catalase (CAT), malondialdehyde (MDA) and prolidase levels were measured in serum to evaluate antioxidant effect of ZJ. Histopathological examination of tissues revealed that highest fibrosis rate was in group 4 (66.84%). Collagen 1 and 3, alpha and beta actin, fibronectin levels were significantly different among groups (p < .05). Differences between plasma SOD, CAT, MDA and prolidase were also significant among those groups (p < .05). In this study, antioxidant and antifibrotic effects of ZJ were determined in the corporal tissue after CNI. It is thought that ZJ may be beneficial on ED patients especially after radical pelvic surgeries.</description><identifier>ISSN: 0303-4569</identifier><identifier>EISSN: 1439-0272</identifier><identifier>DOI: 10.1111/and.13632</identifier><identifier>PMID: 32430921</identifier><language>eng</language><publisher>Germany: Wiley Subscription Services, Inc</publisher><subject>Actin ; Antioxidants ; Biochemical analysis ; Catalase ; cavernosal nerve injury ; Collagen (type I) ; Erectile dysfunction ; Fibronectin ; Fibrosis ; Malondialdehyde ; Oxidative stress ; Prolidase ; Rodents ; Superoxide dismutase ; Surgery ; Ziziphus ; Ziziphus jujuba ; Ziziphus jujube</subject><ispartof>Andrologia, 2020-08, Vol.52 (7), p.e13632-n/a</ispartof><rights>2020 Blackwell Verlag GmbH</rights><rights>2020 Blackwell Verlag GmbH.</rights><rights>Copyright © 2020 Blackwell Verlag GmbH</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3882-c7f200c053e918f55be5693345b38e9ba1399fb671ea969b885f1e9b3f9c2fa03</citedby><cites>FETCH-LOGICAL-c3882-c7f200c053e918f55be5693345b38e9ba1399fb671ea969b885f1e9b3f9c2fa03</cites><orcidid>0000-0003-1652-4792 ; 0000-0002-7946-6916 ; 0000-0002-8296-9717</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fand.13632$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fand.13632$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,780,784,1417,27924,27925,45574,45575</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/32430921$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Resim, Sefa</creatorcontrib><creatorcontrib>Koluş, Eyüp</creatorcontrib><creatorcontrib>Barut, Osman</creatorcontrib><creatorcontrib>Kucukdurmaz, Faruk</creatorcontrib><creatorcontrib>Bahar, Abdulkadir Yasir</creatorcontrib><creatorcontrib>Dagli, Hasan</creatorcontrib><title>Ziziphus jujube ameliorated cavernosal oxidative stress and fibrotic processes in cavernous nerve injury‐induced erectile dysfunction in a rat model</title><title>Andrologia</title><addtitle>Andrologia</addtitle><description>The aim of this study was to investigate potential antioxidant and antifibrotic effects of Ziziphus jujube (ZJ) in a cavernosal nerve injury (CNI)‐induced erectile dysfunction (ED) rat model. Forty‐eight male rats were assigned to six‐sized groups as group 1: sham‐operated; group 2: sham‐operated + low‐dose ZJ (200 mg/kg); group 3: sham‐operated + high‐dose ZJ (400 mg/kg); group 4: CNI + distilled water; group 5: CNI + low‐dose ZJ; and group 6: CNI + high‐dose ZJ. At the end of 2 weeks, intracardiac blood was taken and rats were sacrificed. For biochemical analysis, cavernosal transforming growth factor‐beta‐1, collagen type I and type 3, fibronectin, α and β actin were examined in plasma and cavernosa. Superoxide dismutase (SOD), catalase (CAT), malondialdehyde (MDA) and prolidase levels were measured in serum to evaluate antioxidant effect of ZJ. Histopathological examination of tissues revealed that highest fibrosis rate was in group 4 (66.84%). Collagen 1 and 3, alpha and beta actin, fibronectin levels were significantly different among groups (p < .05). Differences between plasma SOD, CAT, MDA and prolidase were also significant among those groups (p < .05). In this study, antioxidant and antifibrotic effects of ZJ were determined in the corporal tissue after CNI. It is thought that ZJ may be beneficial on ED patients especially after radical pelvic surgeries.</description><subject>Actin</subject><subject>Antioxidants</subject><subject>Biochemical analysis</subject><subject>Catalase</subject><subject>cavernosal nerve injury</subject><subject>Collagen (type I)</subject><subject>Erectile dysfunction</subject><subject>Fibronectin</subject><subject>Fibrosis</subject><subject>Malondialdehyde</subject><subject>Oxidative stress</subject><subject>Prolidase</subject><subject>Rodents</subject><subject>Superoxide dismutase</subject><subject>Surgery</subject><subject>Ziziphus</subject><subject>Ziziphus jujuba</subject><subject>Ziziphus jujube</subject><issn>0303-4569</issn><issn>1439-0272</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><recordid>eNp1kc1u1DAQgC0EoqulB14AWeICh7T-iZP4WJVfqYILXLhEjjMWjhJ7seOW7amPwIkH5EmYsi0HJHyxNfrmG88MIU85O-F4Tk0YT7hspHhANryWumKiFQ_Jhkkmq1o1-ogc5zwxPLVq27p-TI6kqCXTgm_Izy_-2u--lkynMpUBqFlg9jGZFUZqzSWkELOZafzuR7P6S6B5TZAzxbLU-SHF1Vu6S9FiEDL14T4LlQESJvgwlbT_dfPDh7FY1EICu_oZ6LjPrgR8x3CbaCiWpUscYX5CHjkzZzi-u7fk85vXn87fVRcf374_P7uorOw6UdnWCcYsUxI075xSA2DDUtZqkB3owXCptRualoPRjR66TjmOcem0Fc4wuSUvDl7s4FuBvPaLzxbm2QTADnpRo5tJhfPakuf_oFMsKeDvkBKcqaZTDVIvD5RNMecErt8lv5i07znrb_fV4-D6P_tC9tmdsQwLjH_J--0gcHoArnBa-_-b-rMPrw7K35VMon4</recordid><startdate>202008</startdate><enddate>202008</enddate><creator>Resim, Sefa</creator><creator>Koluş, Eyüp</creator><creator>Barut, Osman</creator><creator>Kucukdurmaz, Faruk</creator><creator>Bahar, Abdulkadir Yasir</creator><creator>Dagli, Hasan</creator><general>Wiley Subscription Services, Inc</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TM</scope><scope>K9.</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0003-1652-4792</orcidid><orcidid>https://orcid.org/0000-0002-7946-6916</orcidid><orcidid>https://orcid.org/0000-0002-8296-9717</orcidid></search><sort><creationdate>202008</creationdate><title>Ziziphus jujube ameliorated cavernosal oxidative stress and fibrotic processes in cavernous nerve injury‐induced erectile dysfunction in a rat model</title><author>Resim, Sefa ; Koluş, Eyüp ; Barut, Osman ; Kucukdurmaz, Faruk ; Bahar, Abdulkadir Yasir ; Dagli, Hasan</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3882-c7f200c053e918f55be5693345b38e9ba1399fb671ea969b885f1e9b3f9c2fa03</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><topic>Actin</topic><topic>Antioxidants</topic><topic>Biochemical analysis</topic><topic>Catalase</topic><topic>cavernosal nerve injury</topic><topic>Collagen (type I)</topic><topic>Erectile dysfunction</topic><topic>Fibronectin</topic><topic>Fibrosis</topic><topic>Malondialdehyde</topic><topic>Oxidative stress</topic><topic>Prolidase</topic><topic>Rodents</topic><topic>Superoxide dismutase</topic><topic>Surgery</topic><topic>Ziziphus</topic><topic>Ziziphus jujuba</topic><topic>Ziziphus jujube</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Resim, Sefa</creatorcontrib><creatorcontrib>Koluş, Eyüp</creatorcontrib><creatorcontrib>Barut, Osman</creatorcontrib><creatorcontrib>Kucukdurmaz, Faruk</creatorcontrib><creatorcontrib>Bahar, Abdulkadir Yasir</creatorcontrib><creatorcontrib>Dagli, Hasan</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>Nucleic Acids Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>MEDLINE - Academic</collection><jtitle>Andrologia</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Resim, Sefa</au><au>Koluş, Eyüp</au><au>Barut, Osman</au><au>Kucukdurmaz, Faruk</au><au>Bahar, Abdulkadir Yasir</au><au>Dagli, Hasan</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Ziziphus jujube ameliorated cavernosal oxidative stress and fibrotic processes in cavernous nerve injury‐induced erectile dysfunction in a rat model</atitle><jtitle>Andrologia</jtitle><addtitle>Andrologia</addtitle><date>2020-08</date><risdate>2020</risdate><volume>52</volume><issue>7</issue><spage>e13632</spage><epage>n/a</epage><pages>e13632-n/a</pages><issn>0303-4569</issn><eissn>1439-0272</eissn><abstract>The aim of this study was to investigate potential antioxidant and antifibrotic effects of Ziziphus jujube (ZJ) in a cavernosal nerve injury (CNI)‐induced erectile dysfunction (ED) rat model. Forty‐eight male rats were assigned to six‐sized groups as group 1: sham‐operated; group 2: sham‐operated + low‐dose ZJ (200 mg/kg); group 3: sham‐operated + high‐dose ZJ (400 mg/kg); group 4: CNI + distilled water; group 5: CNI + low‐dose ZJ; and group 6: CNI + high‐dose ZJ. At the end of 2 weeks, intracardiac blood was taken and rats were sacrificed. For biochemical analysis, cavernosal transforming growth factor‐beta‐1, collagen type I and type 3, fibronectin, α and β actin were examined in plasma and cavernosa. Superoxide dismutase (SOD), catalase (CAT), malondialdehyde (MDA) and prolidase levels were measured in serum to evaluate antioxidant effect of ZJ. Histopathological examination of tissues revealed that highest fibrosis rate was in group 4 (66.84%). Collagen 1 and 3, alpha and beta actin, fibronectin levels were significantly different among groups (p < .05). Differences between plasma SOD, CAT, MDA and prolidase were also significant among those groups (p < .05). In this study, antioxidant and antifibrotic effects of ZJ were determined in the corporal tissue after CNI. It is thought that ZJ may be beneficial on ED patients especially after radical pelvic surgeries.</abstract><cop>Germany</cop><pub>Wiley Subscription Services, Inc</pub><pmid>32430921</pmid><doi>10.1111/and.13632</doi><tpages>9</tpages><orcidid>https://orcid.org/0000-0003-1652-4792</orcidid><orcidid>https://orcid.org/0000-0002-7946-6916</orcidid><orcidid>https://orcid.org/0000-0002-8296-9717</orcidid><oa>free_for_read</oa></addata></record> |
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| subjects | Actin Antioxidants Biochemical analysis Catalase cavernosal nerve injury Collagen (type I) Erectile dysfunction Fibronectin Fibrosis Malondialdehyde Oxidative stress Prolidase Rodents Superoxide dismutase Surgery Ziziphus Ziziphus jujuba Ziziphus jujube |
| title | Ziziphus jujube ameliorated cavernosal oxidative stress and fibrotic processes in cavernous nerve injury‐induced erectile dysfunction in a rat model |
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