The effect of exosomes derived from mesenchymal stem cells in the treatment of induced type 1 diabetes mellitus in rats

Aim The aim of the current study was to evaluate the therapeutic and regenerative effects of MSCs derived exosomes in the treatment of type 1 DM and to compare its effects with MSCs themselves. The experiment was done on forty albino rats grouped as follows, group (1): Ten healthy rats, group (2): T...

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Veröffentlicht in:	Biotechnology letters 2020-08, Vol.42 (8), p.1597-1610
Hauptverfasser:	Sabry, Dina, Marzouk, Samar, Zakaria, Reem, Ibrahim, Heba A., Samir, Mai
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Applied Microbiology Beta cells Biochemistry Biomedical and Life Sciences Biotechnology Blood Glucose - analysis Blood Glucose - metabolism Cells, Cultured Diabetes Diabetes mellitus Diabetes mellitus (insulin dependent) Diabetes Mellitus, Experimental - metabolism Diabetes Mellitus, Type 1 - metabolism Exosomes Exosomes - chemistry Exosomes - metabolism Female Gene expression Genes Homeodomain Proteins - metabolism Insulin Insulin - blood Insulin - metabolism Islets of Langerhans - chemistry Islets of Langerhans - metabolism Life Sciences Mesenchymal stem cells Mesenchymal Stem Cells - metabolism Microbiology Original Research Paper Pancreas Rats Regeneration Smad1 Protein - metabolism Smad2 protein Smad2 Protein - metabolism Smad3 protein Stem cell transplantation Stem cells Tissue engineering Trans-Activators - metabolism
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