Natural history of upper and lower gastrointestinal bleeding in hemodialysis patients: A dual‐center long‐term cohort study
Background and Aim Knowledge on the risk of gastrointestinal (GI) bleeding in hemodialysis patients is limited. We evaluated the risk of GI bleeding in hemodialysis patients compared with non‐hemodialysis patients. Methods We performed a retrospective cohort study from 1996 to 2017 at the Graduate S...
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Veröffentlicht in: | Journal of gastroenterology and hepatology 2021-01, Vol.36 (1), p.112-117 |
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creator | Niikura, Ryota Aoki, Tomonori Kojima, Tetsu Kawahara, Takuya Yamada, Atsuo Nakamura, Hideyo Inoue, Kenji Morikoshi, Eita Migita, Raita Shimizu, Toshiko Kojima, Takeshi Koike, Kazuhiko |
description | Background and Aim
Knowledge on the risk of gastrointestinal (GI) bleeding in hemodialysis patients is limited. We evaluated the risk of GI bleeding in hemodialysis patients compared with non‐hemodialysis patients.
Methods
We performed a retrospective cohort study from 1996 to 2017 at the Graduate School of Medicine, University of Tokyo, and Horinouchi Hospital. We analyzed patients on hemodialysis for chronic renal failure and controls not on hemodialysis. The primary endpoint was GI bleeding. A survival analysis was performed to estimate the cumulative incidence and hazard ratio of GI bleeding.
Results
A total of 14 451 patients were analyzed (417 hemodialysis and 14 034 non‐hemodialysis patients). In total, 524 GI bleeding events occurred. Upper and lower GI bleeding occurred in 432 and 92 patients in the hemodialysis and non‐hemodialysis groups, respectively. The most frequent source of upper and lower GI bleeding was gastric ulcer and colonic diverticular bleeding, respectively. The cumulative incidence of GI bleeding was 4.44% at 1 year, 7.15% at 3 years, and 10.40% at 5 years in hemodialysis patients; the respective rates were 2.35%, 2.98%, and 3.79% in non‐hemodialysis patients during a mean follow‐up period of 3.5 years. Hemodialysis was significantly associated with an increased risk of GI bleeding after adjustment (hazard ratio 1.67, P = 0.01, 95% confidence interval 1.13–2.50).
Conclusions
Hemodialysis patients had a GI bleeding rate of 10% over 5 years, and hemodialysis was a risk factor for GI bleeding. |
doi_str_mv | 10.1111/jgh.15110 |
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Knowledge on the risk of gastrointestinal (GI) bleeding in hemodialysis patients is limited. We evaluated the risk of GI bleeding in hemodialysis patients compared with non‐hemodialysis patients.
Methods
We performed a retrospective cohort study from 1996 to 2017 at the Graduate School of Medicine, University of Tokyo, and Horinouchi Hospital. We analyzed patients on hemodialysis for chronic renal failure and controls not on hemodialysis. The primary endpoint was GI bleeding. A survival analysis was performed to estimate the cumulative incidence and hazard ratio of GI bleeding.
Results
A total of 14 451 patients were analyzed (417 hemodialysis and 14 034 non‐hemodialysis patients). In total, 524 GI bleeding events occurred. Upper and lower GI bleeding occurred in 432 and 92 patients in the hemodialysis and non‐hemodialysis groups, respectively. The most frequent source of upper and lower GI bleeding was gastric ulcer and colonic diverticular bleeding, respectively. The cumulative incidence of GI bleeding was 4.44% at 1 year, 7.15% at 3 years, and 10.40% at 5 years in hemodialysis patients; the respective rates were 2.35%, 2.98%, and 3.79% in non‐hemodialysis patients during a mean follow‐up period of 3.5 years. Hemodialysis was significantly associated with an increased risk of GI bleeding after adjustment (hazard ratio 1.67, P = 0.01, 95% confidence interval 1.13–2.50).
Conclusions
Hemodialysis patients had a GI bleeding rate of 10% over 5 years, and hemodialysis was a risk factor for GI bleeding.</description><identifier>ISSN: 0815-9319</identifier><identifier>EISSN: 1440-1746</identifier><identifier>DOI: 10.1111/jgh.15110</identifier><identifier>PMID: 32432811</identifier><language>eng</language><publisher>Australia: Wiley Subscription Services, Inc</publisher><subject>Antidepressants ; Bleeding ; Cohort analysis ; Gastrointestinal bleeding ; Hemodialysis ; Natural history ; Renal failure ; Risk factors ; Survival analysis</subject><ispartof>Journal of gastroenterology and hepatology, 2021-01, Vol.36 (1), p.112-117</ispartof><rights>2020 Journal of Gastroenterology and Hepatology Foundation and John Wiley & Sons Australia, Ltd</rights><rights>2020 Journal of Gastroenterology and Hepatology Foundation and John Wiley & Sons Australia, Ltd.</rights><rights>2021 Journal of Gastroenterology and Hepatology Foundation and John Wiley & Sons Australia, Ltd</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4190-cee819c00528d88b3a70a595b77f69fae20b6f35d7dc7243150c60acc5fcb3ea3</citedby><cites>FETCH-LOGICAL-c4190-cee819c00528d88b3a70a595b77f69fae20b6f35d7dc7243150c60acc5fcb3ea3</cites><orcidid>0000-0001-5047-6195 ; 0000-0003-0794-9940 ; 0000-0002-9739-9243 ; 0000-0003-4314-7777 ; 0000-0002-3859-2756</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fjgh.15110$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fjgh.15110$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,780,784,1417,27924,27925,45574,45575</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/32432811$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Niikura, Ryota</creatorcontrib><creatorcontrib>Aoki, Tomonori</creatorcontrib><creatorcontrib>Kojima, Tetsu</creatorcontrib><creatorcontrib>Kawahara, Takuya</creatorcontrib><creatorcontrib>Yamada, Atsuo</creatorcontrib><creatorcontrib>Nakamura, Hideyo</creatorcontrib><creatorcontrib>Inoue, Kenji</creatorcontrib><creatorcontrib>Morikoshi, Eita</creatorcontrib><creatorcontrib>Migita, Raita</creatorcontrib><creatorcontrib>Shimizu, Toshiko</creatorcontrib><creatorcontrib>Kojima, Takeshi</creatorcontrib><creatorcontrib>Koike, Kazuhiko</creatorcontrib><title>Natural history of upper and lower gastrointestinal bleeding in hemodialysis patients: A dual‐center long‐term cohort study</title><title>Journal of gastroenterology and hepatology</title><addtitle>J Gastroenterol Hepatol</addtitle><description>Background and Aim
Knowledge on the risk of gastrointestinal (GI) bleeding in hemodialysis patients is limited. We evaluated the risk of GI bleeding in hemodialysis patients compared with non‐hemodialysis patients.
Methods
We performed a retrospective cohort study from 1996 to 2017 at the Graduate School of Medicine, University of Tokyo, and Horinouchi Hospital. We analyzed patients on hemodialysis for chronic renal failure and controls not on hemodialysis. The primary endpoint was GI bleeding. A survival analysis was performed to estimate the cumulative incidence and hazard ratio of GI bleeding.
Results
A total of 14 451 patients were analyzed (417 hemodialysis and 14 034 non‐hemodialysis patients). In total, 524 GI bleeding events occurred. Upper and lower GI bleeding occurred in 432 and 92 patients in the hemodialysis and non‐hemodialysis groups, respectively. The most frequent source of upper and lower GI bleeding was gastric ulcer and colonic diverticular bleeding, respectively. The cumulative incidence of GI bleeding was 4.44% at 1 year, 7.15% at 3 years, and 10.40% at 5 years in hemodialysis patients; the respective rates were 2.35%, 2.98%, and 3.79% in non‐hemodialysis patients during a mean follow‐up period of 3.5 years. Hemodialysis was significantly associated with an increased risk of GI bleeding after adjustment (hazard ratio 1.67, P = 0.01, 95% confidence interval 1.13–2.50).
Conclusions
Hemodialysis patients had a GI bleeding rate of 10% over 5 years, and hemodialysis was a risk factor for GI bleeding.</description><subject>Antidepressants</subject><subject>Bleeding</subject><subject>Cohort analysis</subject><subject>Gastrointestinal bleeding</subject><subject>Hemodialysis</subject><subject>Natural history</subject><subject>Renal failure</subject><subject>Risk factors</subject><subject>Survival analysis</subject><issn>0815-9319</issn><issn>1440-1746</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><recordid>eNp1kcFu1DAQhi1ERZfCgRdAlrjAIe1MHMcJt6oqLVUFFzhHju3seuXEwXZU5UQfgWfkSXDZwgGJucyM9OmTfv2EvEI4xTxn--3uFDkiPCEbrCooUFT1U7KBBnnRMmyPyfMY9wBQgeDPyDErK1Y2iBvy_ZNMS5CO7mxMPqzUD3SZZxOonDR1_i5fWxlT8HZKJiY7ZbZ3xmg7bamd6M6MXlvp1mgjnWWyZkrxPT2nepHu5_0Plf_scH7a5i-fI1V-50OiMS16fUGOBumiefm4T8jXD5dfLq6L289XHy_ObwtVYQuFMqbBVgHwstFN0zMpQPKW90IMdTtIU0JfD4xroZXI4ZCDqkEqxQfVMyPZCXl78M7Bf1tykG60URnn5GT8EruyAs6AIdYZffMPuvdLyLkfKCFaAIQqU-8OlAo-xmCGbg52lGHtELqHVrrcSve7lcy-fjQu_Wj0X_JPDRk4OwB31pn1_6bu5ur6oPwFYxmaBA</recordid><startdate>202101</startdate><enddate>202101</enddate><creator>Niikura, Ryota</creator><creator>Aoki, Tomonori</creator><creator>Kojima, Tetsu</creator><creator>Kawahara, Takuya</creator><creator>Yamada, Atsuo</creator><creator>Nakamura, Hideyo</creator><creator>Inoue, Kenji</creator><creator>Morikoshi, Eita</creator><creator>Migita, Raita</creator><creator>Shimizu, Toshiko</creator><creator>Kojima, Takeshi</creator><creator>Koike, Kazuhiko</creator><general>Wiley Subscription Services, Inc</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7T5</scope><scope>7U9</scope><scope>H94</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0001-5047-6195</orcidid><orcidid>https://orcid.org/0000-0003-0794-9940</orcidid><orcidid>https://orcid.org/0000-0002-9739-9243</orcidid><orcidid>https://orcid.org/0000-0003-4314-7777</orcidid><orcidid>https://orcid.org/0000-0002-3859-2756</orcidid></search><sort><creationdate>202101</creationdate><title>Natural history of upper and lower gastrointestinal bleeding in hemodialysis patients: A dual‐center long‐term cohort study</title><author>Niikura, Ryota ; Aoki, Tomonori ; Kojima, Tetsu ; Kawahara, Takuya ; Yamada, Atsuo ; Nakamura, Hideyo ; Inoue, Kenji ; Morikoshi, Eita ; Migita, Raita ; Shimizu, Toshiko ; Kojima, Takeshi ; Koike, Kazuhiko</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4190-cee819c00528d88b3a70a595b77f69fae20b6f35d7dc7243150c60acc5fcb3ea3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>Antidepressants</topic><topic>Bleeding</topic><topic>Cohort analysis</topic><topic>Gastrointestinal bleeding</topic><topic>Hemodialysis</topic><topic>Natural history</topic><topic>Renal failure</topic><topic>Risk factors</topic><topic>Survival analysis</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Niikura, Ryota</creatorcontrib><creatorcontrib>Aoki, Tomonori</creatorcontrib><creatorcontrib>Kojima, Tetsu</creatorcontrib><creatorcontrib>Kawahara, Takuya</creatorcontrib><creatorcontrib>Yamada, Atsuo</creatorcontrib><creatorcontrib>Nakamura, Hideyo</creatorcontrib><creatorcontrib>Inoue, Kenji</creatorcontrib><creatorcontrib>Morikoshi, Eita</creatorcontrib><creatorcontrib>Migita, Raita</creatorcontrib><creatorcontrib>Shimizu, Toshiko</creatorcontrib><creatorcontrib>Kojima, Takeshi</creatorcontrib><creatorcontrib>Koike, Kazuhiko</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>Immunology Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of gastroenterology and hepatology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Niikura, Ryota</au><au>Aoki, Tomonori</au><au>Kojima, Tetsu</au><au>Kawahara, Takuya</au><au>Yamada, Atsuo</au><au>Nakamura, Hideyo</au><au>Inoue, Kenji</au><au>Morikoshi, Eita</au><au>Migita, Raita</au><au>Shimizu, Toshiko</au><au>Kojima, Takeshi</au><au>Koike, Kazuhiko</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Natural history of upper and lower gastrointestinal bleeding in hemodialysis patients: A dual‐center long‐term cohort study</atitle><jtitle>Journal of gastroenterology and hepatology</jtitle><addtitle>J Gastroenterol Hepatol</addtitle><date>2021-01</date><risdate>2021</risdate><volume>36</volume><issue>1</issue><spage>112</spage><epage>117</epage><pages>112-117</pages><issn>0815-9319</issn><eissn>1440-1746</eissn><abstract>Background and Aim
Knowledge on the risk of gastrointestinal (GI) bleeding in hemodialysis patients is limited. We evaluated the risk of GI bleeding in hemodialysis patients compared with non‐hemodialysis patients.
Methods
We performed a retrospective cohort study from 1996 to 2017 at the Graduate School of Medicine, University of Tokyo, and Horinouchi Hospital. We analyzed patients on hemodialysis for chronic renal failure and controls not on hemodialysis. The primary endpoint was GI bleeding. A survival analysis was performed to estimate the cumulative incidence and hazard ratio of GI bleeding.
Results
A total of 14 451 patients were analyzed (417 hemodialysis and 14 034 non‐hemodialysis patients). In total, 524 GI bleeding events occurred. Upper and lower GI bleeding occurred in 432 and 92 patients in the hemodialysis and non‐hemodialysis groups, respectively. The most frequent source of upper and lower GI bleeding was gastric ulcer and colonic diverticular bleeding, respectively. The cumulative incidence of GI bleeding was 4.44% at 1 year, 7.15% at 3 years, and 10.40% at 5 years in hemodialysis patients; the respective rates were 2.35%, 2.98%, and 3.79% in non‐hemodialysis patients during a mean follow‐up period of 3.5 years. Hemodialysis was significantly associated with an increased risk of GI bleeding after adjustment (hazard ratio 1.67, P = 0.01, 95% confidence interval 1.13–2.50).
Conclusions
Hemodialysis patients had a GI bleeding rate of 10% over 5 years, and hemodialysis was a risk factor for GI bleeding.</abstract><cop>Australia</cop><pub>Wiley Subscription Services, Inc</pub><pmid>32432811</pmid><doi>10.1111/jgh.15110</doi><tpages>6</tpages><orcidid>https://orcid.org/0000-0001-5047-6195</orcidid><orcidid>https://orcid.org/0000-0003-0794-9940</orcidid><orcidid>https://orcid.org/0000-0002-9739-9243</orcidid><orcidid>https://orcid.org/0000-0003-4314-7777</orcidid><orcidid>https://orcid.org/0000-0002-3859-2756</orcidid></addata></record> |
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subjects | Antidepressants Bleeding Cohort analysis Gastrointestinal bleeding Hemodialysis Natural history Renal failure Risk factors Survival analysis |
title | Natural history of upper and lower gastrointestinal bleeding in hemodialysis patients: A dual‐center long‐term cohort study |
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