Dermal exposure to the UV filter benzophenone-3 during early pregnancy affects fetal growth and sex ratio of the progeny in mice
The aim of this study was to analyze whether dermal exposure to benzophenone 3 (BP-3) during pregnancy affects critical parameters of pregnancy, and whether this exposure may affect the outcome of a second pregnancy in mice. Pregnant mice were exposed to 50-mg BP-3/kg body weight/day or olive oil (v...
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| Veröffentlicht in: | Archives of toxicology 2020-08, Vol.94 (8), p.2847-2859 |
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| creator | Santamaria, Clarisa Guillermina Meyer, Nicole Schumacher, Anne Zenclussen, María Laura Teglia, Carla Mariela Culzoni, María Julia Zenclussen, Ana Claudia Rodriguez, Horacio Adolfo |
| description | The aim of this study was to analyze whether dermal exposure to benzophenone 3 (BP-3) during pregnancy affects critical parameters of pregnancy, and whether this exposure may affect the outcome of a second pregnancy in mice. Pregnant mice were exposed to 50-mg BP-3/kg body weight/day or olive oil (vehicle) from gestation day (gd) 0 to gd6 by dermal exposure. High-frequency ultrasound imaging was used to follow up fetal and placental growth in vivo. Blood flow parameters in uterine and umbilical arteries were analyzed by Doppler measurements. Mice were killed at gd5, gd10, and gd14 on the first pregnancy, and at gd10 and 14 on the second pregnancy. The weight of the first and second progenies was recorded, and sex ratio was analyzed. BP-3 levels were analyzed in serum and amniotic fluid. BP-3 reduced the fetal weight at gd14 and feto-placenta index of first pregnancy, with 16.13% of fetuses under the 5th percentile;
arteria uterina
parameters showed altered pattern at gd10. BP-3 was detected in serum 4 h after the exposure at gd6, and in amniotic fluid at gd14. Offspring weight of first progeny was lower in BP-3 group. Placenta weights of BP-3 group were decreased in second pregnancy. First and second progenies of mothers exposed to BP-3 showed a higher percentage of females (female sex ratio). Dermal exposure to low dose of BP-3 during early pregnancy resulted in an intrauterine growth restriction (IUGR) phenotype, disturbed sex ratio and alterations in the growth curve of the offspring in mouse model. |
| doi_str_mv | 10.1007/s00204-020-02776-5 |
| format | Article |
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arteria uterina
parameters showed altered pattern at gd10. BP-3 was detected in serum 4 h after the exposure at gd6, and in amniotic fluid at gd14. Offspring weight of first progeny was lower in BP-3 group. Placenta weights of BP-3 group were decreased in second pregnancy. First and second progenies of mothers exposed to BP-3 showed a higher percentage of females (female sex ratio). Dermal exposure to low dose of BP-3 during early pregnancy resulted in an intrauterine growth restriction (IUGR) phenotype, disturbed sex ratio and alterations in the growth curve of the offspring in mouse model.</description><identifier>ISSN: 0340-5761</identifier><identifier>EISSN: 1432-0738</identifier><identifier>DOI: 10.1007/s00204-020-02776-5</identifier><identifier>PMID: 32430675</identifier><language>eng</language><publisher>Berlin/Heidelberg: Springer Berlin Heidelberg</publisher><subject>Amniotic fluid ; Arteries ; Benzophenone ; Biomedical and Life Sciences ; Biomedicine ; Blood flow ; Body weight ; Environmental Health ; Exposure ; Fetuses ; Gestation ; Occupational Medicine/Industrial Medicine ; Offspring ; Olive oil ; Parameters ; Pharmacology/Toxicology ; Phenotypes ; Placenta ; Pregnancy ; Progeny ; Reproductive Toxicology ; Sex ; Sex ratio ; Skin ; Sunscreens ; Ultrasound ; Ultraviolet filters ; Ultraviolet radiation ; Uterus</subject><ispartof>Archives of toxicology, 2020-08, Vol.94 (8), p.2847-2859</ispartof><rights>Springer-Verlag GmbH Germany, part of Springer Nature 2020</rights><rights>Springer-Verlag GmbH Germany, part of Springer Nature 2020.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c375t-ec6a77984a35a0b2e4fe30c6e8b315fde70daf866f2dd3c12eafbd8b3c9fe1563</citedby><cites>FETCH-LOGICAL-c375t-ec6a77984a35a0b2e4fe30c6e8b315fde70daf866f2dd3c12eafbd8b3c9fe1563</cites><orcidid>0000-0002-9251-9402</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s00204-020-02776-5$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s00204-020-02776-5$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,780,784,27922,27923,41486,42555,51317</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/32430675$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Santamaria, Clarisa Guillermina</creatorcontrib><creatorcontrib>Meyer, Nicole</creatorcontrib><creatorcontrib>Schumacher, Anne</creatorcontrib><creatorcontrib>Zenclussen, María Laura</creatorcontrib><creatorcontrib>Teglia, Carla Mariela</creatorcontrib><creatorcontrib>Culzoni, María Julia</creatorcontrib><creatorcontrib>Zenclussen, Ana Claudia</creatorcontrib><creatorcontrib>Rodriguez, Horacio Adolfo</creatorcontrib><title>Dermal exposure to the UV filter benzophenone-3 during early pregnancy affects fetal growth and sex ratio of the progeny in mice</title><title>Archives of toxicology</title><addtitle>Arch Toxicol</addtitle><addtitle>Arch Toxicol</addtitle><description>The aim of this study was to analyze whether dermal exposure to benzophenone 3 (BP-3) during pregnancy affects critical parameters of pregnancy, and whether this exposure may affect the outcome of a second pregnancy in mice. Pregnant mice were exposed to 50-mg BP-3/kg body weight/day or olive oil (vehicle) from gestation day (gd) 0 to gd6 by dermal exposure. High-frequency ultrasound imaging was used to follow up fetal and placental growth in vivo. Blood flow parameters in uterine and umbilical arteries were analyzed by Doppler measurements. Mice were killed at gd5, gd10, and gd14 on the first pregnancy, and at gd10 and 14 on the second pregnancy. The weight of the first and second progenies was recorded, and sex ratio was analyzed. BP-3 levels were analyzed in serum and amniotic fluid. BP-3 reduced the fetal weight at gd14 and feto-placenta index of first pregnancy, with 16.13% of fetuses under the 5th percentile;
arteria uterina
parameters showed altered pattern at gd10. BP-3 was detected in serum 4 h after the exposure at gd6, and in amniotic fluid at gd14. Offspring weight of first progeny was lower in BP-3 group. Placenta weights of BP-3 group were decreased in second pregnancy. First and second progenies of mothers exposed to BP-3 showed a higher percentage of females (female sex ratio). Dermal exposure to low dose of BP-3 during early pregnancy resulted in an intrauterine growth restriction (IUGR) phenotype, disturbed sex ratio and alterations in the growth curve of the offspring in mouse model.</description><subject>Amniotic fluid</subject><subject>Arteries</subject><subject>Benzophenone</subject><subject>Biomedical and Life Sciences</subject><subject>Biomedicine</subject><subject>Blood flow</subject><subject>Body weight</subject><subject>Environmental Health</subject><subject>Exposure</subject><subject>Fetuses</subject><subject>Gestation</subject><subject>Occupational Medicine/Industrial Medicine</subject><subject>Offspring</subject><subject>Olive oil</subject><subject>Parameters</subject><subject>Pharmacology/Toxicology</subject><subject>Phenotypes</subject><subject>Placenta</subject><subject>Pregnancy</subject><subject>Progeny</subject><subject>Reproductive Toxicology</subject><subject>Sex</subject><subject>Sex 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benzophenone-3 during early pregnancy affects fetal growth and sex ratio of the progeny in mice</title><author>Santamaria, Clarisa Guillermina ; Meyer, Nicole ; Schumacher, Anne ; Zenclussen, María Laura ; Teglia, Carla Mariela ; Culzoni, María Julia ; Zenclussen, Ana Claudia ; Rodriguez, Horacio Adolfo</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c375t-ec6a77984a35a0b2e4fe30c6e8b315fde70daf866f2dd3c12eafbd8b3c9fe1563</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><topic>Amniotic fluid</topic><topic>Arteries</topic><topic>Benzophenone</topic><topic>Biomedical and Life Sciences</topic><topic>Biomedicine</topic><topic>Blood flow</topic><topic>Body weight</topic><topic>Environmental Health</topic><topic>Exposure</topic><topic>Fetuses</topic><topic>Gestation</topic><topic>Occupational Medicine/Industrial Medicine</topic><topic>Offspring</topic><topic>Olive oil</topic><topic>Parameters</topic><topic>Pharmacology/Toxicology</topic><topic>Phenotypes</topic><topic>Placenta</topic><topic>Pregnancy</topic><topic>Progeny</topic><topic>Reproductive Toxicology</topic><topic>Sex</topic><topic>Sex ratio</topic><topic>Skin</topic><topic>Sunscreens</topic><topic>Ultrasound</topic><topic>Ultraviolet filters</topic><topic>Ultraviolet radiation</topic><topic>Uterus</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Santamaria, Clarisa Guillermina</creatorcontrib><creatorcontrib>Meyer, Nicole</creatorcontrib><creatorcontrib>Schumacher, Anne</creatorcontrib><creatorcontrib>Zenclussen, María Laura</creatorcontrib><creatorcontrib>Teglia, Carla Mariela</creatorcontrib><creatorcontrib>Culzoni, María Julia</creatorcontrib><creatorcontrib>Zenclussen, Ana Claudia</creatorcontrib><creatorcontrib>Rodriguez, Horacio Adolfo</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest 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Toxicol</addtitle><date>2020-08-01</date><risdate>2020</risdate><volume>94</volume><issue>8</issue><spage>2847</spage><epage>2859</epage><pages>2847-2859</pages><issn>0340-5761</issn><eissn>1432-0738</eissn><abstract>The aim of this study was to analyze whether dermal exposure to benzophenone 3 (BP-3) during pregnancy affects critical parameters of pregnancy, and whether this exposure may affect the outcome of a second pregnancy in mice. Pregnant mice were exposed to 50-mg BP-3/kg body weight/day or olive oil (vehicle) from gestation day (gd) 0 to gd6 by dermal exposure. High-frequency ultrasound imaging was used to follow up fetal and placental growth in vivo. Blood flow parameters in uterine and umbilical arteries were analyzed by Doppler measurements. Mice were killed at gd5, gd10, and gd14 on the first pregnancy, and at gd10 and 14 on the second pregnancy. The weight of the first and second progenies was recorded, and sex ratio was analyzed. BP-3 levels were analyzed in serum and amniotic fluid. BP-3 reduced the fetal weight at gd14 and feto-placenta index of first pregnancy, with 16.13% of fetuses under the 5th percentile;
arteria uterina
parameters showed altered pattern at gd10. BP-3 was detected in serum 4 h after the exposure at gd6, and in amniotic fluid at gd14. Offspring weight of first progeny was lower in BP-3 group. Placenta weights of BP-3 group were decreased in second pregnancy. First and second progenies of mothers exposed to BP-3 showed a higher percentage of females (female sex ratio). Dermal exposure to low dose of BP-3 during early pregnancy resulted in an intrauterine growth restriction (IUGR) phenotype, disturbed sex ratio and alterations in the growth curve of the offspring in mouse model.</abstract><cop>Berlin/Heidelberg</cop><pub>Springer Berlin Heidelberg</pub><pmid>32430675</pmid><doi>10.1007/s00204-020-02776-5</doi><tpages>13</tpages><orcidid>https://orcid.org/0000-0002-9251-9402</orcidid></addata></record> |
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| ispartof | Archives of toxicology, 2020-08, Vol.94 (8), p.2847-2859 |
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| source | SpringerLink Journals - AutoHoldings |
| subjects | Amniotic fluid Arteries Benzophenone Biomedical and Life Sciences Biomedicine Blood flow Body weight Environmental Health Exposure Fetuses Gestation Occupational Medicine/Industrial Medicine Offspring Olive oil Parameters Pharmacology/Toxicology Phenotypes Placenta Pregnancy Progeny Reproductive Toxicology Sex Sex ratio Skin Sunscreens Ultrasound Ultraviolet filters Ultraviolet radiation Uterus |
| title | Dermal exposure to the UV filter benzophenone-3 during early pregnancy affects fetal growth and sex ratio of the progeny in mice |
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