Hematoporphyrin monomethyl ether photodynamic therapy for the treatment of facial port-wine stains resistant to pulsed dye laser
•Assessment of efficacy of hemoporfin/photodynamic therapy for port-wine stains.•Of the 31 lesions, a positive response was obtained in 87.1% after one treatment.•The clinical effect was greater after two sessions.•Adverse effects were well-tolerated and resolved in all cases.•Hemoporfin/photodynami...
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| Veröffentlicht in: | Photodiagnosis and photodynamic therapy 2020-09, Vol.31, p.101820-101820, Article 101820 |
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| creator | Zhang, Mengli Wu, Qiuju Lin, Tong Guo, Lifang Ge, Yiping Zeng, Rong Yang, Yin Rong, Huizhen Jia, Gaorong Huang, Yuqing Fang, Jing Shi, Hualing Zhao, Wenwen Chen, SanJing Cai, Pingping |
| description | •Assessment of efficacy of hemoporfin/photodynamic therapy for port-wine stains.•Of the 31 lesions, a positive response was obtained in 87.1% after one treatment.•The clinical effect was greater after two sessions.•Adverse effects were well-tolerated and resolved in all cases.•Hemoporfin/photodynamic therapy is effective for resistant port-wine stains.
Pulsed dye laser is the first treatment choice for port-wine stains. However, as some facial port-wine stains are resistant to this modality, we evaluated the efficacy and safety of hematoporphyrin monomethyl ether (hemoporfin) photodynamic therapy for the treatment of such resistant port-wine stains.
Patients were treated with two sessions of hemoporfin photodynamic therapy in our department. Patients received an intravenous injection of hematoporphyrin monomethyl ether (5 mg/kg) followed by 532 nm LED green light therapy. Three physicians graded the improvement in the port-wine stain, using a 4-level scale. Patients’ satisfaction, reaction to treatment, and adverse effects were evaluated.
Thirty-one patients (mean age, 23.9 ± 11.9 years, range, 3−48 years) were enrolled in this study. Hypertrophic lesions accounted for 48.4% of port-wine stain, with 80.6% of lesions being larger than 40 cm2. With regard to location, 41.9% were located on the central face and 32.3% involved a mix of the central and peripheral face. After one session, a treatment response was identified in 87.1% of cases, with the response deemed ‘significant’ in 29.0%. After two sessions, these rates increased to 100.0% and 61.3%, respectively. The clinical effect after two sessions was significantly greater than that after one session. Treatment reactions and adverse effects were well tolerated, and included pruritus, burning sensation, pain, edema, purpura-like change, blister, crust, and hyperpigmentation.
Hemoporfin photodynamic therapy is a promising treatment for port-wine stains resistant to pulsed dye laser therapy. |
| doi_str_mv | 10.1016/j.pdpdt.2020.101820 |
| format | Article |
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Pulsed dye laser is the first treatment choice for port-wine stains. However, as some facial port-wine stains are resistant to this modality, we evaluated the efficacy and safety of hematoporphyrin monomethyl ether (hemoporfin) photodynamic therapy for the treatment of such resistant port-wine stains.
Patients were treated with two sessions of hemoporfin photodynamic therapy in our department. Patients received an intravenous injection of hematoporphyrin monomethyl ether (5 mg/kg) followed by 532 nm LED green light therapy. Three physicians graded the improvement in the port-wine stain, using a 4-level scale. Patients’ satisfaction, reaction to treatment, and adverse effects were evaluated.
Thirty-one patients (mean age, 23.9 ± 11.9 years, range, 3−48 years) were enrolled in this study. Hypertrophic lesions accounted for 48.4% of port-wine stain, with 80.6% of lesions being larger than 40 cm2. With regard to location, 41.9% were located on the central face and 32.3% involved a mix of the central and peripheral face. After one session, a treatment response was identified in 87.1% of cases, with the response deemed ‘significant’ in 29.0%. After two sessions, these rates increased to 100.0% and 61.3%, respectively. The clinical effect after two sessions was significantly greater than that after one session. Treatment reactions and adverse effects were well tolerated, and included pruritus, burning sensation, pain, edema, purpura-like change, blister, crust, and hyperpigmentation.
Hemoporfin photodynamic therapy is a promising treatment for port-wine stains resistant to pulsed dye laser therapy.</description><identifier>ISSN: 1572-1000</identifier><identifier>EISSN: 1873-1597</identifier><identifier>DOI: 10.1016/j.pdpdt.2020.101820</identifier><identifier>PMID: 32428574</identifier><language>eng</language><publisher>Netherlands: Elsevier B.V</publisher><subject>Adolescent ; Adult ; Child ; Hematoporphyrin monomethyl ; Hematoporphyrins ; Hemoporfin ; Humans ; Laser Therapy ; Lasers, Dye - therapeutic use ; Photochemotherapy - methods ; Photodynamic therapy ; Photosensitizing Agents - therapeutic use ; Port wine stain ; Port-Wine Stain - drug therapy ; Pulsed dye laser ; Resistant ; Treatment Outcome ; Young Adult</subject><ispartof>Photodiagnosis and photodynamic therapy, 2020-09, Vol.31, p.101820-101820, Article 101820</ispartof><rights>2020</rights><rights>Copyright © 2020. Published by Elsevier B.V.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c359t-7a4b2799446f0c85ffe5c809577f88289fca21f04032dc9a32c693cbf2c7eb643</citedby><cites>FETCH-LOGICAL-c359t-7a4b2799446f0c85ffe5c809577f88289fca21f04032dc9a32c693cbf2c7eb643</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.pdpdt.2020.101820$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3550,27924,27925,45995</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/32428574$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Zhang, Mengli</creatorcontrib><creatorcontrib>Wu, Qiuju</creatorcontrib><creatorcontrib>Lin, Tong</creatorcontrib><creatorcontrib>Guo, Lifang</creatorcontrib><creatorcontrib>Ge, Yiping</creatorcontrib><creatorcontrib>Zeng, Rong</creatorcontrib><creatorcontrib>Yang, Yin</creatorcontrib><creatorcontrib>Rong, Huizhen</creatorcontrib><creatorcontrib>Jia, Gaorong</creatorcontrib><creatorcontrib>Huang, Yuqing</creatorcontrib><creatorcontrib>Fang, Jing</creatorcontrib><creatorcontrib>Shi, Hualing</creatorcontrib><creatorcontrib>Zhao, Wenwen</creatorcontrib><creatorcontrib>Chen, SanJing</creatorcontrib><creatorcontrib>Cai, Pingping</creatorcontrib><title>Hematoporphyrin monomethyl ether photodynamic therapy for the treatment of facial port-wine stains resistant to pulsed dye laser</title><title>Photodiagnosis and photodynamic therapy</title><addtitle>Photodiagnosis Photodyn Ther</addtitle><description>•Assessment of efficacy of hemoporfin/photodynamic therapy for port-wine stains.•Of the 31 lesions, a positive response was obtained in 87.1% after one treatment.•The clinical effect was greater after two sessions.•Adverse effects were well-tolerated and resolved in all cases.•Hemoporfin/photodynamic therapy is effective for resistant port-wine stains.
Pulsed dye laser is the first treatment choice for port-wine stains. However, as some facial port-wine stains are resistant to this modality, we evaluated the efficacy and safety of hematoporphyrin monomethyl ether (hemoporfin) photodynamic therapy for the treatment of such resistant port-wine stains.
Patients were treated with two sessions of hemoporfin photodynamic therapy in our department. Patients received an intravenous injection of hematoporphyrin monomethyl ether (5 mg/kg) followed by 532 nm LED green light therapy. Three physicians graded the improvement in the port-wine stain, using a 4-level scale. Patients’ satisfaction, reaction to treatment, and adverse effects were evaluated.
Thirty-one patients (mean age, 23.9 ± 11.9 years, range, 3−48 years) were enrolled in this study. Hypertrophic lesions accounted for 48.4% of port-wine stain, with 80.6% of lesions being larger than 40 cm2. With regard to location, 41.9% were located on the central face and 32.3% involved a mix of the central and peripheral face. After one session, a treatment response was identified in 87.1% of cases, with the response deemed ‘significant’ in 29.0%. After two sessions, these rates increased to 100.0% and 61.3%, respectively. The clinical effect after two sessions was significantly greater than that after one session. Treatment reactions and adverse effects were well tolerated, and included pruritus, burning sensation, pain, edema, purpura-like change, blister, crust, and hyperpigmentation.
Hemoporfin photodynamic therapy is a promising treatment for port-wine stains resistant to pulsed dye laser therapy.</description><subject>Adolescent</subject><subject>Adult</subject><subject>Child</subject><subject>Hematoporphyrin monomethyl</subject><subject>Hematoporphyrins</subject><subject>Hemoporfin</subject><subject>Humans</subject><subject>Laser Therapy</subject><subject>Lasers, Dye - therapeutic use</subject><subject>Photochemotherapy - methods</subject><subject>Photodynamic therapy</subject><subject>Photosensitizing Agents - therapeutic use</subject><subject>Port wine stain</subject><subject>Port-Wine Stain - drug therapy</subject><subject>Pulsed dye laser</subject><subject>Resistant</subject><subject>Treatment Outcome</subject><subject>Young Adult</subject><issn>1572-1000</issn><issn>1873-1597</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kDFvFDEQhS1ERELgFyAhlzR7zNre87qgQBEkSJFooLZ89ljn0-7a2D7Qdvz0-HIJJc3M09ObGc1HyLseNj3024-HTXLJ1Q0D9uiMDF6Qq36UvOsHJV82PUjW9QBwSV6XcgDgQoF4RS45E2wcpLgif-9wNjWmmNN-zWGhc1zijHW_TrRVzDTtY41uXcwcLD05Jq3Ux3zStGY0dcal0uipNzaYibZdtfsTFqSlmrAUmrGEJluoRpqOU0FH3Yp0MgXzG3LhTbPePvVr8vPrlx83d93999tvN5_vO8sHVTtpxI5JpYTYerDj4D0OdgQ1SOnHkY3KW8N6DwI4c1YZzuxWcbvzzErcbQW_Jh_Oe1OOv45Yqp5DsThNZsF4LJoJGDiwxrFF-Tlqcywlo9cph9nkVfegT-j1QT-i1yf0-oy-Tb1_OnDczej-zTyzboFP5wC2N38HzLrYgItFFzLaql0M_z3wAHeHmNQ</recordid><startdate>202009</startdate><enddate>202009</enddate><creator>Zhang, Mengli</creator><creator>Wu, Qiuju</creator><creator>Lin, Tong</creator><creator>Guo, Lifang</creator><creator>Ge, Yiping</creator><creator>Zeng, Rong</creator><creator>Yang, Yin</creator><creator>Rong, Huizhen</creator><creator>Jia, Gaorong</creator><creator>Huang, Yuqing</creator><creator>Fang, Jing</creator><creator>Shi, Hualing</creator><creator>Zhao, Wenwen</creator><creator>Chen, SanJing</creator><creator>Cai, Pingping</creator><general>Elsevier B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>202009</creationdate><title>Hematoporphyrin monomethyl ether photodynamic therapy for the treatment of facial port-wine stains resistant to pulsed dye laser</title><author>Zhang, Mengli ; Wu, Qiuju ; Lin, Tong ; Guo, Lifang ; Ge, Yiping ; Zeng, Rong ; Yang, Yin ; Rong, Huizhen ; Jia, Gaorong ; Huang, Yuqing ; Fang, Jing ; Shi, Hualing ; Zhao, Wenwen ; Chen, SanJing ; Cai, Pingping</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c359t-7a4b2799446f0c85ffe5c809577f88289fca21f04032dc9a32c693cbf2c7eb643</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><topic>Adolescent</topic><topic>Adult</topic><topic>Child</topic><topic>Hematoporphyrin monomethyl</topic><topic>Hematoporphyrins</topic><topic>Hemoporfin</topic><topic>Humans</topic><topic>Laser Therapy</topic><topic>Lasers, Dye - therapeutic use</topic><topic>Photochemotherapy - methods</topic><topic>Photodynamic therapy</topic><topic>Photosensitizing Agents - therapeutic use</topic><topic>Port wine stain</topic><topic>Port-Wine Stain - drug therapy</topic><topic>Pulsed dye laser</topic><topic>Resistant</topic><topic>Treatment Outcome</topic><topic>Young Adult</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Zhang, Mengli</creatorcontrib><creatorcontrib>Wu, Qiuju</creatorcontrib><creatorcontrib>Lin, Tong</creatorcontrib><creatorcontrib>Guo, Lifang</creatorcontrib><creatorcontrib>Ge, Yiping</creatorcontrib><creatorcontrib>Zeng, Rong</creatorcontrib><creatorcontrib>Yang, Yin</creatorcontrib><creatorcontrib>Rong, Huizhen</creatorcontrib><creatorcontrib>Jia, Gaorong</creatorcontrib><creatorcontrib>Huang, Yuqing</creatorcontrib><creatorcontrib>Fang, Jing</creatorcontrib><creatorcontrib>Shi, Hualing</creatorcontrib><creatorcontrib>Zhao, Wenwen</creatorcontrib><creatorcontrib>Chen, SanJing</creatorcontrib><creatorcontrib>Cai, Pingping</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Photodiagnosis and photodynamic therapy</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Zhang, Mengli</au><au>Wu, Qiuju</au><au>Lin, Tong</au><au>Guo, Lifang</au><au>Ge, Yiping</au><au>Zeng, Rong</au><au>Yang, Yin</au><au>Rong, Huizhen</au><au>Jia, Gaorong</au><au>Huang, Yuqing</au><au>Fang, Jing</au><au>Shi, Hualing</au><au>Zhao, Wenwen</au><au>Chen, SanJing</au><au>Cai, Pingping</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Hematoporphyrin monomethyl ether photodynamic therapy for the treatment of facial port-wine stains resistant to pulsed dye laser</atitle><jtitle>Photodiagnosis and photodynamic therapy</jtitle><addtitle>Photodiagnosis Photodyn Ther</addtitle><date>2020-09</date><risdate>2020</risdate><volume>31</volume><spage>101820</spage><epage>101820</epage><pages>101820-101820</pages><artnum>101820</artnum><issn>1572-1000</issn><eissn>1873-1597</eissn><abstract>•Assessment of efficacy of hemoporfin/photodynamic therapy for port-wine stains.•Of the 31 lesions, a positive response was obtained in 87.1% after one treatment.•The clinical effect was greater after two sessions.•Adverse effects were well-tolerated and resolved in all cases.•Hemoporfin/photodynamic therapy is effective for resistant port-wine stains.
Pulsed dye laser is the first treatment choice for port-wine stains. However, as some facial port-wine stains are resistant to this modality, we evaluated the efficacy and safety of hematoporphyrin monomethyl ether (hemoporfin) photodynamic therapy for the treatment of such resistant port-wine stains.
Patients were treated with two sessions of hemoporfin photodynamic therapy in our department. Patients received an intravenous injection of hematoporphyrin monomethyl ether (5 mg/kg) followed by 532 nm LED green light therapy. Three physicians graded the improvement in the port-wine stain, using a 4-level scale. Patients’ satisfaction, reaction to treatment, and adverse effects were evaluated.
Thirty-one patients (mean age, 23.9 ± 11.9 years, range, 3−48 years) were enrolled in this study. Hypertrophic lesions accounted for 48.4% of port-wine stain, with 80.6% of lesions being larger than 40 cm2. With regard to location, 41.9% were located on the central face and 32.3% involved a mix of the central and peripheral face. After one session, a treatment response was identified in 87.1% of cases, with the response deemed ‘significant’ in 29.0%. After two sessions, these rates increased to 100.0% and 61.3%, respectively. The clinical effect after two sessions was significantly greater than that after one session. Treatment reactions and adverse effects were well tolerated, and included pruritus, burning sensation, pain, edema, purpura-like change, blister, crust, and hyperpigmentation.
Hemoporfin photodynamic therapy is a promising treatment for port-wine stains resistant to pulsed dye laser therapy.</abstract><cop>Netherlands</cop><pub>Elsevier B.V</pub><pmid>32428574</pmid><doi>10.1016/j.pdpdt.2020.101820</doi><tpages>1</tpages></addata></record> |
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| subjects | Adolescent Adult Child Hematoporphyrin monomethyl Hematoporphyrins Hemoporfin Humans Laser Therapy Lasers, Dye - therapeutic use Photochemotherapy - methods Photodynamic therapy Photosensitizing Agents - therapeutic use Port wine stain Port-Wine Stain - drug therapy Pulsed dye laser Resistant Treatment Outcome Young Adult |
| title | Hematoporphyrin monomethyl ether photodynamic therapy for the treatment of facial port-wine stains resistant to pulsed dye laser |
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