Bioinspired Fabrication of Calcium-Doped TiP Coating with Nanofibrous Microstructure to Accelerate Osseointegration
Bioinspired by the morphology of osteoclast-resorbed bone surfaces, we prepared a calcium-doped titanium phosphate (Ca-TiP) coating, which consists of a nanofibrous network, on titanium (Ti) substrate via a simple two-step hydrothermal method, trying to mimic natural bone compositionally and microst...
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| Veröffentlicht in: | Bioconjugate chemistry 2020-06, Vol.31 (6), p.1641-1650 |
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| container_title | Bioconjugate chemistry |
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| creator | Cai, Bianyun Tan, Peijie Jiang, Nan Guo, Zhijun Ay, Birol Li, Shujun Hou, Yi Li, Yubao You, Yanjun Zhang, Li Zhu, Songsong |
| description | Bioinspired by the morphology of osteoclast-resorbed bone surfaces, we prepared a calcium-doped titanium phosphate (Ca-TiP) coating, which consists of a nanofibrous network, on titanium (Ti) substrate via a simple two-step hydrothermal method, trying to mimic natural bone compositionally and microstructurally. The
studies show that the Ca-TiP coating with synergistic features of nanofibrous biomimetic topography and surface chemistry could elicit intensively osteogenic behavior and responses including enhanced cell adhesion, spreading, and proliferation as well as alkaline phosphatase (ALP) activity and up-regulated expression of bone-related genes, which inevitably benefit the formation of new bone and the quality of osseointegration. When the two control groups are compared
, the significantly improved new bone formation in the early stage and the much stronger interfacial bonding with the surrounding bone for Ca-TiP coating suggest that Ca-TiP coating modified Ti implants hold great potential for orthopedic and dental applications. |
| doi_str_mv | 10.1021/acs.bioconjchem.0c00201 |
| format | Article |
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studies show that the Ca-TiP coating with synergistic features of nanofibrous biomimetic topography and surface chemistry could elicit intensively osteogenic behavior and responses including enhanced cell adhesion, spreading, and proliferation as well as alkaline phosphatase (ALP) activity and up-regulated expression of bone-related genes, which inevitably benefit the formation of new bone and the quality of osseointegration. When the two control groups are compared
, the significantly improved new bone formation in the early stage and the much stronger interfacial bonding with the surrounding bone for Ca-TiP coating suggest that Ca-TiP coating modified Ti implants hold great potential for orthopedic and dental applications.</description><identifier>ISSN: 1043-1802</identifier><identifier>EISSN: 1520-4812</identifier><identifier>DOI: 10.1021/acs.bioconjchem.0c00201</identifier><identifier>PMID: 32426977</identifier><language>eng</language><publisher>United States: American Chemical Society</publisher><subject>Alkaline phosphatase ; Alkaline Phosphatase - metabolism ; Animals ; Biomedical materials ; Biomimetics ; Bonding strength ; Bone growth ; Bone implants ; Calcium ; Calcium - chemistry ; Calcium phosphates ; Cell adhesion ; Cell adhesion & migration ; Cell Adhesion - drug effects ; Cell Proliferation - drug effects ; Coated Materials, Biocompatible - chemistry ; Coated Materials, Biocompatible - pharmacology ; Coating ; Coatings ; Dental materials ; Dental prosthetics ; Fabrication ; Female ; Gene expression ; Gene Expression Regulation - drug effects ; Interfacial bonding ; Male ; Morphology ; Nanofibers - chemistry ; Orthopedics ; Osseointegration ; Osseointegration - drug effects ; Osteogenesis ; Rats ; Rats, Sprague-Dawley ; Substrates ; Surface chemistry ; Surgical implants ; Titanium ; Titanium - chemistry</subject><ispartof>Bioconjugate chemistry, 2020-06, Vol.31 (6), p.1641-1650</ispartof><rights>Copyright American Chemical Society Jun 17, 2020</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c341t-48963f2f47219c250f8913b0dacd679fe36182c8e6f44e5cc855ba9edede86f63</citedby><cites>FETCH-LOGICAL-c341t-48963f2f47219c250f8913b0dacd679fe36182c8e6f44e5cc855ba9edede86f63</cites><orcidid>0000-0002-0324-5092</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,2752,27901,27902</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/32426977$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Cai, Bianyun</creatorcontrib><creatorcontrib>Tan, Peijie</creatorcontrib><creatorcontrib>Jiang, Nan</creatorcontrib><creatorcontrib>Guo, Zhijun</creatorcontrib><creatorcontrib>Ay, Birol</creatorcontrib><creatorcontrib>Li, Shujun</creatorcontrib><creatorcontrib>Hou, Yi</creatorcontrib><creatorcontrib>Li, Yubao</creatorcontrib><creatorcontrib>You, Yanjun</creatorcontrib><creatorcontrib>Zhang, Li</creatorcontrib><creatorcontrib>Zhu, Songsong</creatorcontrib><title>Bioinspired Fabrication of Calcium-Doped TiP Coating with Nanofibrous Microstructure to Accelerate Osseointegration</title><title>Bioconjugate chemistry</title><addtitle>Bioconjug Chem</addtitle><description>Bioinspired by the morphology of osteoclast-resorbed bone surfaces, we prepared a calcium-doped titanium phosphate (Ca-TiP) coating, which consists of a nanofibrous network, on titanium (Ti) substrate via a simple two-step hydrothermal method, trying to mimic natural bone compositionally and microstructurally. The
studies show that the Ca-TiP coating with synergistic features of nanofibrous biomimetic topography and surface chemistry could elicit intensively osteogenic behavior and responses including enhanced cell adhesion, spreading, and proliferation as well as alkaline phosphatase (ALP) activity and up-regulated expression of bone-related genes, which inevitably benefit the formation of new bone and the quality of osseointegration. When the two control groups are compared
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The
studies show that the Ca-TiP coating with synergistic features of nanofibrous biomimetic topography and surface chemistry could elicit intensively osteogenic behavior and responses including enhanced cell adhesion, spreading, and proliferation as well as alkaline phosphatase (ALP) activity and up-regulated expression of bone-related genes, which inevitably benefit the formation of new bone and the quality of osseointegration. When the two control groups are compared
, the significantly improved new bone formation in the early stage and the much stronger interfacial bonding with the surrounding bone for Ca-TiP coating suggest that Ca-TiP coating modified Ti implants hold great potential for orthopedic and dental applications.</abstract><cop>United States</cop><pub>American Chemical Society</pub><pmid>32426977</pmid><doi>10.1021/acs.bioconjchem.0c00201</doi><tpages>10</tpages><orcidid>https://orcid.org/0000-0002-0324-5092</orcidid></addata></record> |
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| subjects | Alkaline phosphatase Alkaline Phosphatase - metabolism Animals Biomedical materials Biomimetics Bonding strength Bone growth Bone implants Calcium Calcium - chemistry Calcium phosphates Cell adhesion Cell adhesion & migration Cell Adhesion - drug effects Cell Proliferation - drug effects Coated Materials, Biocompatible - chemistry Coated Materials, Biocompatible - pharmacology Coating Coatings Dental materials Dental prosthetics Fabrication Female Gene expression Gene Expression Regulation - drug effects Interfacial bonding Male Morphology Nanofibers - chemistry Orthopedics Osseointegration Osseointegration - drug effects Osteogenesis Rats Rats, Sprague-Dawley Substrates Surface chemistry Surgical implants Titanium Titanium - chemistry |
| title | Bioinspired Fabrication of Calcium-Doped TiP Coating with Nanofibrous Microstructure to Accelerate Osseointegration |
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