FGF15 improves outcomes after brain dead donor liver transplantation with steatotic and non-steatotic grafts in rats

Donation after brain death (DBD) grafts are associated with reduced graft quality and function post liver transplantation (LT). We aimed to elucidate i) the impact of FGF15 levels on DBD grafts; ii) whether this impact resulted from altered intestinal FXR-FGF15; iii) whether administration of FGF15...

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Veröffentlicht in:	Journal of hepatology 2020-11, Vol.73 (5), p.1131-1143
Hauptverfasser:	Gulfo, José, Rotondo, Floriana, Ávalos de León, Cindy G., Cornide-Petronio, María Eugenia, Fuster, Carla, Gracia-Sancho, Jordi, Jiménez-Castro, Mónica B., Peralta, Carmen
Format:	Artikel
Sprache:	eng
Schlagworte:	Acids Bile Bile acids Brain death Brain injury Cell proliferation Cell surface Cholic acid Death FGF15 Fibroblast growth factor receptor 4 Intestine IQGAP1 protein Ischemia-reperfusion Liver Liver diseases Liver transplantation Organ donors Regeneration Steatotic liver grafts Toxicity Yes-associated protein
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