Association between maternal active smoking during pregnancy and placental weight: The Japan environment and Children's study
Maternal smoking during pregnancy is a well-known risk factor for reduced birthweight. However, research investigating the association between maternal smoking and placental weight is scarce and inconsistent. Our study was conducted to evaluate the association between maternal smoking and placental...
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| Veröffentlicht in: | Placenta (Eastbourne) 2020-05, Vol.94, p.48-53 |
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| creator | Mitsuda, N. N Awn, J.P. Eitoku, M. Maeda, N Fujieda, M. Suganuma, N. Kamijima, Michihiro Yamazaki, Shin Ohya, Yukihiro Kishi, Reiko Yaegashi, Nobuo Hashimoto, Koichi Mori, Chisato Ito, Shuichi Yamagata, Zentaro Inadera, Hidekuni Nakayama, Takeo Iso, Hiroyasu Shima, Masayuki Kurozawa, Youichi Suganuma, Narufumi Kusuhara, Koichi Katoh, Takahiko |
| description | Maternal smoking during pregnancy is a well-known risk factor for reduced birthweight. However, research investigating the association between maternal smoking and placental weight is scarce and inconsistent. Our study was conducted to evaluate the association between maternal smoking and placental weight and placental weight/birthweight ratio (PW/BW ratio).
We used data from a birth cohort study, the Japan Environment and Children's Study (JECS). Main outcome measures were placental weight, PW/BW ratio, and the risk of high PW/BW ratio. High PW/BW ratio was defined as PW/BW ratio above the 90th percentile for gestational age and sex of offspring. The association between maternal smoking and placental weight was estimated as crude and as adjusted beta coefficients by applying linear regression analyses. Logistic regression analyses were also performed to estimate the association between maternal smoking and the risk of high PW/BW ratio.
Of the 91,951 pregnant women, the mean placental weight and the mean PW/BW ratio were lowest for the group of women who had never smoked. Smokers had higher odds ratio for high PW/BW ratio compared with non-smokers. Furthermore, among smokers, the mean placental weight and mean PW/BW ratio were lowest in women who smoked less than 5 daily cigarettes, and highest in women who smoked 20 or more daily cigarettes during pregnancy.
Placental weight was greater and PW/BW ratio was higher among smokers compared with non-smokers. Moreover, the number of daily cigarettes was positively associated with heavy placental weight.
•Placental weight was greater among smokers compared with non-smokers.•Placental weight/birthweight ratio was higher among smokers compared with non-smokers.•The number of daily cigarettes was also positively associated with heavy placental weight. |
| doi_str_mv | 10.1016/j.placenta.2020.04.001 |
| format | Article |
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We used data from a birth cohort study, the Japan Environment and Children's Study (JECS). Main outcome measures were placental weight, PW/BW ratio, and the risk of high PW/BW ratio. High PW/BW ratio was defined as PW/BW ratio above the 90th percentile for gestational age and sex of offspring. The association between maternal smoking and placental weight was estimated as crude and as adjusted beta coefficients by applying linear regression analyses. Logistic regression analyses were also performed to estimate the association between maternal smoking and the risk of high PW/BW ratio.
Of the 91,951 pregnant women, the mean placental weight and the mean PW/BW ratio were lowest for the group of women who had never smoked. Smokers had higher odds ratio for high PW/BW ratio compared with non-smokers. Furthermore, among smokers, the mean placental weight and mean PW/BW ratio were lowest in women who smoked less than 5 daily cigarettes, and highest in women who smoked 20 or more daily cigarettes during pregnancy.
Placental weight was greater and PW/BW ratio was higher among smokers compared with non-smokers. Moreover, the number of daily cigarettes was positively associated with heavy placental weight.
•Placental weight was greater among smokers compared with non-smokers.•Placental weight/birthweight ratio was higher among smokers compared with non-smokers.•The number of daily cigarettes was also positively associated with heavy placental weight.</description><identifier>ISSN: 0143-4004</identifier><identifier>EISSN: 1532-3102</identifier><identifier>DOI: 10.1016/j.placenta.2020.04.001</identifier><identifier>PMID: 32421535</identifier><language>eng</language><publisher>Netherlands: Elsevier Ltd</publisher><subject>Adult ; Birth Weight ; Cohort Studies ; Female ; Gestational Age ; Humans ; Infant, Newborn ; Japan ; JECS ; Male ; Maternal smoking ; Organ Size ; Placenta - anatomy & histology ; Placental weight to birthweight ratio ; Pregnancy ; Smoking - adverse effects ; Surveys and Questionnaires</subject><ispartof>Placenta (Eastbourne), 2020-05, Vol.94, p.48-53</ispartof><rights>2020 Elsevier Ltd</rights><rights>Copyright © 2020 Elsevier Ltd. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c434t-1102cb81dc9f527092bd40e511ec4867d383a646fca344bd0f5c27fa1875e7ea3</citedby><cites>FETCH-LOGICAL-c434t-1102cb81dc9f527092bd40e511ec4867d383a646fca344bd0f5c27fa1875e7ea3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0143400420301053$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65306</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/32421535$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Mitsuda, N.</creatorcontrib><creatorcontrib>N Awn, J.P.</creatorcontrib><creatorcontrib>Eitoku, M.</creatorcontrib><creatorcontrib>Maeda, N</creatorcontrib><creatorcontrib>Fujieda, M.</creatorcontrib><creatorcontrib>Suganuma, N.</creatorcontrib><creatorcontrib>Kamijima, Michihiro</creatorcontrib><creatorcontrib>Yamazaki, Shin</creatorcontrib><creatorcontrib>Ohya, Yukihiro</creatorcontrib><creatorcontrib>Kishi, Reiko</creatorcontrib><creatorcontrib>Yaegashi, Nobuo</creatorcontrib><creatorcontrib>Hashimoto, Koichi</creatorcontrib><creatorcontrib>Mori, Chisato</creatorcontrib><creatorcontrib>Ito, Shuichi</creatorcontrib><creatorcontrib>Yamagata, Zentaro</creatorcontrib><creatorcontrib>Inadera, Hidekuni</creatorcontrib><creatorcontrib>Nakayama, Takeo</creatorcontrib><creatorcontrib>Iso, Hiroyasu</creatorcontrib><creatorcontrib>Shima, Masayuki</creatorcontrib><creatorcontrib>Kurozawa, Youichi</creatorcontrib><creatorcontrib>Suganuma, Narufumi</creatorcontrib><creatorcontrib>Kusuhara, Koichi</creatorcontrib><creatorcontrib>Katoh, Takahiko</creatorcontrib><creatorcontrib>Japan Environment and Children’s Study (JECS) Group</creatorcontrib><title>Association between maternal active smoking during pregnancy and placental weight: The Japan environment and Children's study</title><title>Placenta (Eastbourne)</title><addtitle>Placenta</addtitle><description>Maternal smoking during pregnancy is a well-known risk factor for reduced birthweight. However, research investigating the association between maternal smoking and placental weight is scarce and inconsistent. Our study was conducted to evaluate the association between maternal smoking and placental weight and placental weight/birthweight ratio (PW/BW ratio).
We used data from a birth cohort study, the Japan Environment and Children's Study (JECS). Main outcome measures were placental weight, PW/BW ratio, and the risk of high PW/BW ratio. High PW/BW ratio was defined as PW/BW ratio above the 90th percentile for gestational age and sex of offspring. The association between maternal smoking and placental weight was estimated as crude and as adjusted beta coefficients by applying linear regression analyses. Logistic regression analyses were also performed to estimate the association between maternal smoking and the risk of high PW/BW ratio.
Of the 91,951 pregnant women, the mean placental weight and the mean PW/BW ratio were lowest for the group of women who had never smoked. Smokers had higher odds ratio for high PW/BW ratio compared with non-smokers. Furthermore, among smokers, the mean placental weight and mean PW/BW ratio were lowest in women who smoked less than 5 daily cigarettes, and highest in women who smoked 20 or more daily cigarettes during pregnancy.
Placental weight was greater and PW/BW ratio was higher among smokers compared with non-smokers. Moreover, the number of daily cigarettes was positively associated with heavy placental weight.
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However, research investigating the association between maternal smoking and placental weight is scarce and inconsistent. Our study was conducted to evaluate the association between maternal smoking and placental weight and placental weight/birthweight ratio (PW/BW ratio).
We used data from a birth cohort study, the Japan Environment and Children's Study (JECS). Main outcome measures were placental weight, PW/BW ratio, and the risk of high PW/BW ratio. High PW/BW ratio was defined as PW/BW ratio above the 90th percentile for gestational age and sex of offspring. The association between maternal smoking and placental weight was estimated as crude and as adjusted beta coefficients by applying linear regression analyses. Logistic regression analyses were also performed to estimate the association between maternal smoking and the risk of high PW/BW ratio.
Of the 91,951 pregnant women, the mean placental weight and the mean PW/BW ratio were lowest for the group of women who had never smoked. Smokers had higher odds ratio for high PW/BW ratio compared with non-smokers. Furthermore, among smokers, the mean placental weight and mean PW/BW ratio were lowest in women who smoked less than 5 daily cigarettes, and highest in women who smoked 20 or more daily cigarettes during pregnancy.
Placental weight was greater and PW/BW ratio was higher among smokers compared with non-smokers. Moreover, the number of daily cigarettes was positively associated with heavy placental weight.
•Placental weight was greater among smokers compared with non-smokers.•Placental weight/birthweight ratio was higher among smokers compared with non-smokers.•The number of daily cigarettes was also positively associated with heavy placental weight.</abstract><cop>Netherlands</cop><pub>Elsevier Ltd</pub><pmid>32421535</pmid><doi>10.1016/j.placenta.2020.04.001</doi><tpages>6</tpages></addata></record> |
| fulltext | fulltext |
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| ispartof | Placenta (Eastbourne), 2020-05, Vol.94, p.48-53 |
| issn | 0143-4004 1532-3102 |
| language | eng |
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| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | Adult Birth Weight Cohort Studies Female Gestational Age Humans Infant, Newborn Japan JECS Male Maternal smoking Organ Size Placenta - anatomy & histology Placental weight to birthweight ratio Pregnancy Smoking - adverse effects Surveys and Questionnaires |
| title | Association between maternal active smoking during pregnancy and placental weight: The Japan environment and Children's study |
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