Andrographolide modulates HNF4α activity imparting on hepatic metabolism

Hepatic nuclear factor 4 alpha (HNF4α) drives the expression of apolipoprotein B (ApoB), microsomal triglyceride transfer protein (MTP) and phospholipase A2 G12B (PLA2G12B), governing hepatic very-low-density lipoprotein (VLDL) production and secretion. Andrographolide (AP) is a major constituent is...

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Veröffentlicht in:	Molecular and cellular endocrinology 2020-08, Vol.513, p.110867-110867, Article 110867
Hauptverfasser:	Zhang, Minyi, Yang, Meng, Wang, Na, Liu, Qingli, Wang, Binxu, Huang, Tongling, Tong, Yan, Ming, Yanlin, Wong, Chi-Wai, Liu, Jinsong, Yao, Dongsheng, Guan, Min
Format:	Artikel
Sprache:	eng
Schlagworte:	Andrographolide Gluconeogenesis Hepatocyte nuclear factor 4 alpha Transcriptional regulation Very-low-density lipoprotein secretion
Online-Zugang:	Volltext
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