The dynamics of γ-secretase and its substrates

γ-Secretase is an intramembrane aspartyl-protease catalyzing the final step in the regulated intramembrane proteolysis of a large number of single-span type-1 transmembrane proteins. The most extensively studied substrates are the amyloid-β precursor protein (APP) and the NOTCH receptors. An importa...

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Veröffentlicht in:	Seminars in cell & developmental biology 2020-09, Vol.105, p.86-101
Hauptverfasser:	Hitzenberger, Manuel, Götz, Alexander, Menig, Simon, Brunschweiger, Barbara, Zacharias, Martin, Scharnagl, Christina
Format:	Artikel
Sprache:	eng
Online-Zugang:	Volltext
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