Chronic hyperglycemia impairs hippocampal neurogenesis and memory in an Alzheimer’s disease mouse model

During aging, lifestyle-related factors shape the brain's response to insults and modulate the progression of neurodegenerative pathologies such as Alzheimer's disease (AD). This is the case for chronic hyperglycemia associated with type 2 diabetes, which reduces the brain's ability t...

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Veröffentlicht in:	Neurobiology of aging 2020-08, Vol.92, p.98-113
Hauptverfasser:	Ferreiro, Elisabete, Lanzillo, Mariagrazia, Canhoto, Diogo, Carvalho da Silva, António M., Mota, Sandra I., Dias, Inês S., Ferreira, Ildete L., Fontes, Ana R., Mastrella, Giorgia, Pinheiro, Paulo, Valero, Jorge, Rego, A. Cristina
Format:	Artikel
Sprache:	eng
Schlagworte:	Alzheimer’s disease Chronic hyperglycemia Hippocampal neurogenesis Immature neurons Memory impairment Synaptic facilitation β-Catenin
Online-Zugang:	Volltext
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