Intraarticular Adeno‐Associated Virus Serotype AAV‐PHP.S–Mediated Chemogenetic Targeting of Knee‐Innervating Dorsal Root Ganglion Neurons Alleviates Inflammatory Pain in Mice

Objective Joint pain is the major clinical symptom of arthritis that affects millions of people. Controlling the excitability of knee‐innervating dorsal root ganglion (DRG) neurons (knee neurons) could potentially provide pain relief. We undertook this study to evaluate whether the newly engineered...

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Veröffentlicht in:	Arthritis & rheumatology (Hoboken, N.J.) N.J.), 2020-10, Vol.72 (10), p.1749-1758
Hauptverfasser:	Chakrabarti, Sampurna, Pattison, Luke A., Doleschall, Balint, Rickman, Rebecca H., Blake, Helen, Callejo, Gerard, Heppenstall, Paul A., Smith, Ewan St. John
Format:	Artikel
Sprache:	eng
Schlagworte:	Activation Animals Arthritis Dependovirus Disease Models, Animal Dorsal root ganglia Electrophysiology Excitability Fluorescence Ganglia, Spinal - metabolism Genetic Therapy - methods Immunohistochemistry In vivo methods and tests Inflammation Inflammation - genetics Inflammation - metabolism Inflammation - therapy Joint diseases Joints (anatomy) Knee Knee Joint - metabolism Mice Neurons Neurons - metabolism Pain Pain - metabolism Pain Management - methods Receptors Unmanned aerial vehicles Variance analysis Viruses
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