Effect of Quercetin on PC12 Alzheimer's Disease Cell Model Induced by A β 25-35 and Its Mechanism Based on Sirtuin1/Nrf2/HO-1 Pathway

This study is aimed at studying the effect of quercetin on the Alzheimer disease cell model induced by A in PC12 cells and its mechanism of action. The AD cell model was established by A . Quercetin was used at different concentrations (0, 10, 20, 40, and 80 mol/L). The morphology of cells was obse...

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Veröffentlicht in:	BioMed research international 2020, Vol.2020, p.8210578-10
Hauptverfasser:	Yu, Xinjun, Li, Yicai, Mu, Xiaohua
Format:	Artikel
Sprache:	eng
Schlagworte:	Alzheimer Disease - genetics Alzheimer Disease - metabolism Alzheimer Disease - pathology Amyloid beta-Peptides - genetics Amyloid beta-Peptides - metabolism Animals Cell Survival - drug effects Cell Survival - genetics Heme Oxygenase (Decyclizing) - genetics Heme Oxygenase (Decyclizing) - metabolism Models, Neurological NF-E2-Related Factor 2 - genetics NF-E2-Related Factor 2 - metabolism PC12 Cells Peptide Fragments - genetics Peptide Fragments - metabolism Quercetin - pharmacology Rats Signal Transduction - drug effects Signal Transduction - genetics Sirtuin 1 - metabolism
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