Insulin-like growth factor-1 receptor induces immunosuppression in lung cancer by upregulating B7–H4 expression through the MEK/ERK signaling pathway

The Insulin-like growth factor-1/Insulin-like growth factor-1 receptor (IGF1/IGF1R) axis contributes to immunosuppression during tumor progression; however, the underlying mechanism remains unclear. In the present study, we found that IGF1 stimulation or IGF1R overexpression (IGF1R-OE) could upregul...

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Veröffentlicht in:	Cancer letters 2020-08, Vol.485, p.14-26
Hauptverfasser:	Zhao, Zhiming, Zhang, Ningyue, Li, Anqi, Zhou, Bin, Chen, Yali, Chen, Shaomu, Huang, Moli, Wu, Fengying, Zhang, Liang
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Aged Aged, 80 and over Animals Antibodies B7 antigen B7-H4 (VTCN1) Cancer immunotherapy CD8 antigen CD8+ T cell CD8-Positive T-Lymphocytes - immunology Cell Line, Tumor Cloning Extracellular signal-regulated kinase Female Flow cytometry Gene Expression Regulation, Neoplastic Genomes Humans Immune Tolerance Immunosuppression Immunotherapy Insulin Insulin-like growth factor I Insulin-like growth factor-1 receptor (IGF1R) Insulin-like growth factors Kinases Lung cancer Lung Neoplasms - drug therapy Lung Neoplasms - immunology Lymphocytes Lymphocytes T Male MAP Kinase Signaling System - drug effects MAP Kinase Signaling System - physiology Medical research MEK/ERK Metabolic pathways Metastases Mice Mice, Inbred C57BL Middle Aged Receptor, IGF Type 1 - physiology Signal transduction Therapeutic applications Tumor cell lines V-Set Domain-Containing T-Cell Activation Inhibitor 1 - genetics
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