The association between receptor binding affinity and metabolic side effect profile of antipsychotics and major cardio- and cerebrovascular events: A case/non-case study using VigiBase

•APs with high affinity for Adrenergic alfa-1, Histaminic H1, Muscarinic M1, and Serotoninergic 5-HT2A were associated with a higher risk of reporting of MACCE compared to low affinity.•MACCE reporting rates might be related to those receptors antagonism as ziprasidone, olanzapine, and clozapine pre...

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Veröffentlicht in:	European neuropsychopharmacology 2020-06, Vol.35, p.30-38
Hauptverfasser:	Aguiar, João Pedro, Alves da Costa, Filipa, Egberts, Toine, Leufkens, Hubert, Souverein, Patrick
Format:	Artikel
Sprache:	eng
Schlagworte:	Antipsychotics Major adverse Cardio- and cerebrovascular events Pharmacoepidemiology Pharmacovigilance
Online-Zugang:	Volltext
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