Central serous chorioretinopathy: An update on risk factors, pathophysiology and imaging modalities
Central serous chorioretinopathy (CSC) is a common form of vision loss, typically seen in working-age men. The pathophysiology behind CSC still eludes us, however significant advances have been made in understanding this disease over the last decade using information from genetic and cell-based stud...
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| Veröffentlicht in: | Progress in retinal and eye research 2020-11, Vol.79, p.100865-100865, Article 100865 |
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| container_title | Progress in retinal and eye research |
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| creator | Kaye, Rebecca Chandra, Shruti Sheth, Jay Boon, Camiel J.F. Sivaprasad, Sobha Lotery, Andrew |
| description | Central serous chorioretinopathy (CSC) is a common form of vision loss, typically seen in working-age men. The pathophysiology behind CSC still eludes us, however significant advances have been made in understanding this disease over the last decade using information from genetic and cell-based studies and imaging modalities. This review aims to give an overview of the current pathophysiology hypotheses surrounding CSC in addition to future directions in cellular work from human induced pluripotent stem cell derived choroidal endothelial cells from CSC patients. Furthermore, this review will provide the reader with an update on the clinical aspects of CSC including risk factors, diagnostic challenges and findings from multimodal imaging. |
| doi_str_mv | 10.1016/j.preteyeres.2020.100865 |
| format | Article |
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The pathophysiology behind CSC still eludes us, however significant advances have been made in understanding this disease over the last decade using information from genetic and cell-based studies and imaging modalities. This review aims to give an overview of the current pathophysiology hypotheses surrounding CSC in addition to future directions in cellular work from human induced pluripotent stem cell derived choroidal endothelial cells from CSC patients. 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The pathophysiology behind CSC still eludes us, however significant advances have been made in understanding this disease over the last decade using information from genetic and cell-based studies and imaging modalities. This review aims to give an overview of the current pathophysiology hypotheses surrounding CSC in addition to future directions in cellular work from human induced pluripotent stem cell derived choroidal endothelial cells from CSC patients. Furthermore, this review will provide the reader with an update on the clinical aspects of CSC including risk factors, diagnostic challenges and findings from multimodal imaging.</description><subject>Central serous chorioretinopathy (CSC)</subject><subject>Central Serous Chorioretinopathy - diagnosis</subject><subject>Central Serous Chorioretinopathy - physiopathology</subject><subject>Choroid</subject><subject>Choroid - pathology</subject><subject>Choroidal endothelial cells (CECs)</subject><subject>Complement factor H (CFH)</subject><subject>Corticosteroids</subject><subject>Eplerenone</subject><subject>Fluorescein Angiography - methods</subject><subject>Fundus Oculi</subject><subject>Humans</subject><subject>Hyperpermeability</subject><subject>Mineralocorticoids</subject><subject>Pachychoroid</subject><subject>Retinal pigment epithelium (RPE)</subject><subject>Retinal Pigment Epithelium - pathology</subject><subject>Risk Factors</subject><subject>Tomography, Optical Coherence - methods</subject><subject>Visual Acuity</subject><issn>1350-9462</issn><issn>1873-1635</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkE9v2zAMxYWhxfpn-wqDjj3MKW1Zst1bF3RtgQK9dGeBlphEmWN5klLA374K0m3HQgcKxO-RfI8xXsKihFJdbxdToEQzBYqLCqpDG1olP7Hzsm1EUSohT_JfSCi6WlVn7CLGLQAo6ORndiaqGpquac-ZWdKYAg48UvD7yM3GB-fzcDf6CdNmvuG3I99PFhNxP_Lg4m--QpN8iN_5gfDTZo7OD349cxwtdztcu3HNd97i4JKj-IWdrnCI9PW9XrJfP-9elg_F0_P94_L2qTB1B6lQDViwVtW2LU3X1wI7QIWVVGCRlOxraVBUuBKV6K3soSmVUrYFxCxSjbhkV8e5U_B_9hST3rloaBhwpOxNZ9P5yU6KjLZH1AQfY6CVnkI-PMy6BH2IWG_1_4j1IWJ9jDhLv71v2fc7sv-EfzPNwI8jQNnrq6Ogo3E0GrIukEnaevfxljeAWZQm</recordid><startdate>202011</startdate><enddate>202011</enddate><creator>Kaye, Rebecca</creator><creator>Chandra, Shruti</creator><creator>Sheth, Jay</creator><creator>Boon, Camiel J.F.</creator><creator>Sivaprasad, Sobha</creator><creator>Lotery, Andrew</creator><general>Elsevier Ltd</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>202011</creationdate><title>Central serous chorioretinopathy: An update on risk factors, pathophysiology and imaging modalities</title><author>Kaye, Rebecca ; 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| ispartof | Progress in retinal and eye research, 2020-11, Vol.79, p.100865-100865, Article 100865 |
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| source | MEDLINE; ScienceDirect Journals (5 years ago - present) |
| subjects | Central serous chorioretinopathy (CSC) Central Serous Chorioretinopathy - diagnosis Central Serous Chorioretinopathy - physiopathology Choroid Choroid - pathology Choroidal endothelial cells (CECs) Complement factor H (CFH) Corticosteroids Eplerenone Fluorescein Angiography - methods Fundus Oculi Humans Hyperpermeability Mineralocorticoids Pachychoroid Retinal pigment epithelium (RPE) Retinal Pigment Epithelium - pathology Risk Factors Tomography, Optical Coherence - methods Visual Acuity |
| title | Central serous chorioretinopathy: An update on risk factors, pathophysiology and imaging modalities |
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