Mesenchymal stem cells engineered by modified polyethylenimine polymer for targeted cancer gene therapy, in vitro and in vivo

Cell‐based delivery system is a promising strategy to protect therapeutic agents from the immune system and provide targeted delivery. Mesenchymal stem cells (MSCs) have recently been introduced as an encouraging vehicle in cell‐based gene therapy due to their unique features including tumor‐tropic...

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Veröffentlicht in:	Biotechnology progress 2020-11, Vol.36 (6), p.e3025-n/a
Hauptverfasser:	Salmasi, Zahra, Hashemi, Maryam, Mahdipour, Elahe, Nourani, Hossein, Abnous, Khalil, Ramezani, Mohammad
Format:	Artikel
Sprache:	eng
Schlagworte:	Apoptosis Biocompatibility Cell death Cell migration cellular vehicle Chemical compounds Cytotoxicity Flow cytometry Fluorescence Gene expression Gene therapy genetic engineering Heterocyclic amines Immune system Ligands Melanoma Mesenchymal stem cells Mortality nonviral vector Pharmacology Polyethyleneimine Polymers Stem cell transplantation Stem cells targeted tumor suppression Toxicity TRAIL protein Tumor necrosis factor Tumor necrosis factor-TNF Tumor suppression Tumors
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