Application of Transition-Metal Catalysis, Biocatalysis, and Flow Chemistry as State-of-the-Art Technologies in the Synthesis of LCZ696
LCZ696 is a novel treatment for patients suffering from heart failure that combines the two active pharmaceutical ingredients sacubitril and valsartan in a single chemical compound. While valsartan is an established drug substance, a new manufacturing process suitable for large-scale commercial prod...
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| Veröffentlicht in: | Journal of organic chemistry 2020-06, Vol.85 (11), p.6844-6853 |
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| creator | Gu, Xingxian Zhao, Jibin Chen, Like Li, Yunzhong Yu, Bo Tian, Xiangguang Min, Zhongcheng Xu, Su Gu, Huijuan Sun, Junjie Lu, Xiaoquan Chang, Meng Wang, Xufan Zhao, Liqun Ye, Shengqing Yang, Hongwei Tian, Yingtao Gao, Feng Gai, Yu Jia, Guanghua Wu, Jingjing Wang, Yan Zhang, Jianghua Zhang, Xuesong Liu, Weichun Gu, Xin Luo, Xi Dong, Hai Wang, Huaimin Schenkel, Berthold Venturoni, Francesco Filipponi, Paolo Guelat, Bertrand Allmendinger, Thomas Wietfeld, Bernhard Hoehn, Pascale Kovacic, Nikola Hermann, Luca Schlama, Thierry Ruch, Thomas Derrien, Nadine Piechon, Philippe Kleinbeck, Florian |
| description | LCZ696 is a novel treatment for patients suffering from heart failure that combines the two active pharmaceutical ingredients sacubitril and valsartan in a single chemical compound. While valsartan is an established drug substance, a new manufacturing process suitable for large-scale commercial production had to be developed for sacubitril. The use of chemocatalysis, biocatalysis, and flow chemistry as state-of-the-art technologies allowed to efficiently build up the structure of sacubitril and achieve the defined performance targets. |
| doi_str_mv | 10.1021/acs.joc.0c00473 |
| format | Article |
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While valsartan is an established drug substance, a new manufacturing process suitable for large-scale commercial production had to be developed for sacubitril. 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| source | American Chemical Society Journals |
| title | Application of Transition-Metal Catalysis, Biocatalysis, and Flow Chemistry as State-of-the-Art Technologies in the Synthesis of LCZ696 |
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